Genetic variation in the androgen receptor gene and endometrial cancer risk

Cancer Epidemiology Biomarkers and Prevention

Volumn 18, Issue 2, 2009, Pages 585-589

  Yang, Hannah P ^a,b   Garcia Closas, Montserrat ^a   Lacey, James V ^a   Brinton, Louise A ^a   Lissowska, Jolanta ^a,c   Peplonska, Beta ^d   Chanock, Stephen ^a   Gaudet, Mia M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c INSTITUTE OF ONCOLOGY   (Poland)

^d NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR;

ARTICLE; CANCER RISK; CONTROLLED STUDY; ENDOMETRIUM CANCER; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; CASE-CONTROL STUDIES; ENDOMETRIAL NEOPLASMS; FEMALE; GENETIC VARIATION; GENOTYPE; HAPLOTYPES; HUMANS; LOGISTIC MODELS; POLAND; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ANDROGEN; RISK FACTORS;

EID: 60549087154     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-08-0677     Document Type: Article

References (21)

1. Ito K, Suzuki T, Akahira J, et al. Expression of androgen receptor and 5a-reductases in the human normal endometrium and its disorders. Int J Cancer 2002;99:652-7.
2. Nantermet PV, Masarachia P, Gentile MA, et al. Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways. Endocrinology 2005;146:564-78.
3. Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P. Role of exogenous and endogenous hormones in endometrial cancer: review of the evidence and research perspectives. Ann N Y Acad Sci 2001;943:296-315.
4. Lukanova A, Lundin E, Micheli A, et al. Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women. Int J Cancer 2004;108:425-32.
5. Potischman N, Hoover RN, Brinton LA, et al. Case-control study of endogenous steroid hormones and endometrial cancer. J Natl Cancer Inst 1996;88:1127-35.
6. Faber PW, Kuiper GG, van Rooij HC, van der Korput JA, Brinkmann AO, Trapman J. The N-terminal domain of the human androgen receptor is encoded by one, large exon. Mol Cell Endocrinol 1989;61:257-62.
7. Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994;22:3181-6.
8. Kazemi-Esfarjani P, Trifiro MA, Pinsky L. Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor: Possible pathogenetic relevance for the (CAG)n-expanded neuronopathies. Hum Mol Genet 1995;4:523-7.
9. Yaron M, Levy T, Chetrit A, et al. The polymorphic CAG repeat in the androgen receptor gene in Jewish Israeli women with endome-trial carcinoma. Cancer 2001;92:1190-4.
10. Sasaki M, Sakuragi N, Dahiya R. The CAG repeats in exon 1 of the androgen receptor gene are significantly longer in endome-trial cancer patients. Biochem Biophys Res Commun 2003;305:1105-8.
11. McGrath M, Lee IM, Hankinson SE, et al. Androgen receptor polymorphisms and endometrial cancer risk. Int J Cancer 2006;118:1261-8.
12. Brinton LA, Sakoda LC, Lissowska J, et al. Reproductive risk factors for endometrial cancer among polish women. Br J Cancer 2007;96:1450-6.
13. Gaudet MM, Lacey JV, Jr., Lissowska J, et al. Genetic variation in CYP17 and endometrial cancer risk. Hum Genet 2008;123:155-62.
14. Cox DG, Blanche H, Pearce CL, et al. A comprehensive analysis of the androgen receptor gene and risk of breast cancer: Results from the national cancer institute breast and prostate cancer cohort consortium (BPC3). Breast Cancer Res 2006;8:R54.
15. Packer BR, Yeager M, Burdett L, et al. SNP500Cancer: A public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res 2006;34:D617-21.
16. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002;70:425-34.
17. Westfall PH, Young SS. Resampling-based multiple testing. New York (NY): John Wiley & Sons, Inc.; 1993.
18. Buchanan G, Yang M, Cheong A, et al. Structural and functional consequences of glutamine tract variation in the androgen receptor. Hum Mol Genet 2004;13:1677-92.
19. Edwards A, Hammond HA, Jin L, Caskey CT, Chakraborty R. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 1992;12:241-53.
20. Tran N, Bharaj BS, Diamandis EP, Smith M, Li BD, Yu H. Short tandem repeat polymorphism and cancer risk: Influence of laboratory analysis on epidemiologic findings. Cancer Epidemiol Bio-markers Prev 2004;13:2133-40.
21. Morton LM, Cahill J, Hartge P. Reporting participation in epidemiologic studies: A survey of practice. Am J Epidemiol 2006;163:197-203.