Optimisation of HPLC gradient separations using artificial neural networks (ANNs): Application to benzodiazepines in post-mortem samples

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 7, 2009, Pages 615-620

  Webb, Rebecca ^a   Doble, Philip ^a   Dawson, Michael ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

Artificial neural networks (ANNs); Benzodiazepines; Gradient elution; HPLC; Optimisation

Indexed keywords

ACETONITRILE; BACKPROPAGATION; SEPARATION;

ARTIFICIAL NEURAL NETWORKS (ANNS); BENZODIAZEPINES; GRADIENT ELUTION; HPLC; OPTIMISATION;

NEURAL NETWORKS;

7 AMINO 1,3 DIHYDRO 5 PHENYL 2H 1,4 BENZODIAZEPIN 2 ONE; 7 AMINOFLUNITRAZEPAM; ACETONITRILE; ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BUFFER; DIAZEPAM; FLUNITRAZEPAM; FORMIC ACID; METHANE; NITRAZEPAM; OXAZEPAM; TEMAZEPAM;

ARTICLE; AUTOPSY; BLOOD SAMPLING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NERVE CELL NETWORK; PRIORITY JOURNAL; VALIDATION STUDY;

ANIMALS; AUTOPSY; BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; NEURAL NETWORKS (COMPUTER); SHEEP;

EID: 60449100437     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.01.012     Document Type: Article

References (15)

1. Buscema M. Subst. Use Misuse 37 (2002) 1093
2. Doble P., Sandercock M., Du Pasquier E., Petocz P., Roux C., and Dawson M. Forensic Sci. Int. 132 (2003) 26
3. Zupan J., and Gasteiger J. Neural Networks in Chemistry and Drug Design (1999), Wiley-VCH
4. Metting H.J., and Coenegracht P.M. J. Chromatogr. A 728 (1996) 47
5. Agatonovic-Kustrin S., Zecevic M., Zivanovic L., and Tucker I.G. Anal. Chim. Acta 364 (1998) 265
6. Havlis J., Madden J.E., Revilla A.L., and Havel J. J. Chromatogr. B 755 (2001) 185
7. Marengo E., Gianotti V., Angioi S., and Gennaro M.C. J. Chromatogr. A 1029 (2004) 57
8. Wang H., and Liu W. J. Sep. Sci. 27 (2004) 1189
9. Coenegracht P.M.J., Metting H.J., van Loo E.M., Snoeijer G.J., and Doornbos D.A. J. Chromatogr. 631 (1993) 145
10. Booth T.D., Azzaoui K., and Wainer I.W. Anal. Chem. 69 (1997) 3879
11. Madden J.E., Avdalovic N., Haddad P.R., and Havel J. J. Chromatogr. A 910 (2001) 173
12. Bucinski A., and Baczek T. Polish J. Food Nutr. Sci. 11 (2002) 47
13. Shan Y., Zhao R., Zhang Y., Zhang W., and Tian Y. J. Sep. Sci. 26 (2003) 1541
14. Maurer H.H., Kraemer T., Kratzsch C., Peters F.T., and Weber A.A. Ther. Drug Monit. 24 (2002) 117
15. Zakaria P., Macka M., and Haddad P.R. J. Chromatogr. A 997 (2003) 207