Does progesterone inhibit bacteria-stimulated interleukin-8 production by lower genital tract epithelial cells?

Journal of Perinatal Medicine

Volumn 37, Issue 4, 2009, Pages 328-333

  Peltier, Morgan R ^a   Berlin, Yana ^a,b   Tee, Siew C ^b   Smulian, John C ^c  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c LEHIGH VALLEY HOSPITAL   (United States)

Author keywords

Infection; Innate immunity; Preterm birth; Progesterone; Vaginal immunity

Indexed keywords

INTERLEUKIN 8; PROGESTERONE;

ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FEMALE; GARDNERELLA VAGINALIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATION; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; UREAPLASMA UREALYTICUM; UTERINE CERVIX EPITHELIUM; VAGINA EPITHELIUM;

CELL LINE; CERVIX UTERI; EPITHELIAL CELLS; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-8; PREMATURE BIRTH; PROGESTERONE; VAGINA;

EID: 60449091855     PISSN: 03005577     EISSN: 16193997     Source Type: Journal    
DOI: 10.1515/JPM.2009.064     Document Type: Article

References (29)

1. Barclay CG, Brennand JE, Kelly RW, Calder AA. Interleukin-8 production by the human cervix. Am J Obstet Gynecol. 1993;169:625-32.
2. Cauci S, Guaschino S, Driussi S, De Santo D, Lanzafame P, Quadrifoglio F. Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis. J Infect Dis. 2002;185:1614-20.
3. Chilton BS, Gettys KL, Newman MG, McAllister CJ, Cowart KT. Differential responses of rabbit endocervix and uterus to medroxyprogesterone acetate. Steroids. 1985; 46:915-27.
4. Chilton BS, Deeb EA, Dalley BK. Progesterone regulates epidermal growth factor receptor on mucous secreting cells in the rabbit endocervix. Endocrinology. 1991;129: 2094-100.
5. Chwalisz K, Benson M, Scholz P, Daum J, Beier HM, Hegele-Hartung C. Cervical ripening with the cytokines interleukin 8, interleukin 1 beta and tumour necrosis factor alpha in guinea-pigs. Hum Reprod. 1994;9:2173-81.
6. da Fonseca EB, Bittar RE, Carvalho MH, Zugaib M. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol. 2003; 188:419-24.
7. DeFranco EA, O'Brien JM, Adair CD, Lewis DF, Hall DR, Fusey S, et al. Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2007;30:697-705.
8. el Maradny E, Kanayama N, Halim A, Maehara K, Sumimoto K, Terao T. Interleukin-8 induces cervical ripening in rabbits. Am J Obstet Gynecol. 1994;171:77-83.
9. El Maradny E, Kanayama N, Halim A, Maehara K, Sumimoto K, Terao T. Biochemical changes in the cervical tissue of rabbit induced by interleukin-8, interleukin-1beta, dehydroepiandrosterone sulphate and prostaglandin E2: a comparative study. Hum Reprod. 1996;11:1099-104.
10. Fichorova RN, Rheinwald JG, Andersen DJ. Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod. 1997;57:847-55.
11. Fichorova RN, Anderson DJ. Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells. Biol Reprod. 1999;60: 508-14.
12. Fichorova RN, Desai PJ, Gibson FC 3rd, Genco CA. Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells. Infect Immun. 2001;69:5840-8.
13. Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007;357:462-9.
14. Furr P, Taylor-Robinson D. Colonization of the respiratory and genital tracts of female mice with Mycoplasma pneumoniae and protection afforded to the genital tract by prior respiratory colonization. Int J Exp Pathol. 1999;80:35-9.
15. Furr PM, Taylor-Robinson D. Factors influencing the ability of different mycoplasmas to colonize the genital tract of hormone-treated female mice. Int J Exp Pathol. 1993;74: 97-101.
16. Gillgrass AE, Ashkar AA, Rosenthal KL, Kaushic C. Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J Virol. 2003;77:9845-51.
17. Holst RM, Mattsby-Baltzer I, Wennerholm UB, Hagberg H, Jacobsson B. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand. 2005;84:551-7.
18. Ito A, Imada K, Sato T, Kubo T, Matsushima K, Mori Y. Suppression of interleukin 8 production by progesterone in rabbit uterine cervix. Biochem J. 1994;301(Pt 1):183-6.
19. Johnson JW, Austin KL, Jones GS, Davis GH, King TM. Efficacy of 17alpha-hydroxyprogesterone caproate in the prevention of premature labor. N Engl J Med. 1975;293: 675-80.
20. Kaushic C, Zhou F, Murdin AD, Wira CR. Effects of estradiol and progesterone on susceptibility and early immune responses to Chlamydia trachomatis infection in the female reproductive tract. Infect Immun. 2000;68:4207-16.
21. Lahav M, Sofer N, Brandes JM, Paldi E, Barzilai D. Placental concentrations of progesterone, estradiol-17 beta, and cyclic AMP at delivery. Obstet Gynecol. 1980;56: 616-20.
22. Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med. 2003;348:2379-85.
23. Peltier MR, Wilcox CJ, Sharp DC. Technical note: Application of the Box-Cox data transformation to animal science experiments. J Anim Sci. 1998;76:847-9.
24. Pessina MA, Hoyt RF, Goldstein I, Traish AM. Differential effects of estradiol, progesterone and testosterone on vaginal structural integrity. Endocrinology. 2006;147:61-9.
25. Russell CA, Vindelov LL. Optimization and comparison of the MTT assay and the 3H-TdR assay for the detection of IL-2 in helper T cell precursor assays. J Immunol Methods. 1998;217:165-75.
26. Sagawa T, Furuta I, Negishi H, Kishida T, Begum S, Fujimoto S. Cytokines concentrations in the cervical mucus of pregnant women. J Obstet Gynaecol Res. 1996;22:517-22.
27. Simhan HN, Caritis SN, Krohn MA, Martinez de Tejada B, Landers DV, Hillier SL. Decreased cervical proinflammatory cytokines permit subsequent upper genital tract infection during pregnancy. Am J Obstet Gynecol. 2003;189:560-7.
28. Wasiela M, Brzezinska-Blaszczyk E, Krzeminski Z, Kalinka J. [Impact of Mycoplasma hominis and Ureaplasma urealyticum on the concentration of proinflammatory cytokines in vaginal fluid]. Med Dosw Mikrobiol. 2004;56:371-6.
29. Watari M, Watari H, Fujimoto T, Yamada H, Nishihira J, Strauss JF, et al. Lipopolysaccharide induces interleukin-8 production by human cervical smooth muscle cells. J Soc Gynecol Investig. 2003;10:110-7.