Nitric oxide induces apoptosis of the hair cells of cochlea

Acta Oto-Laryngologica, Supplement

Volumn 124, Issue 554, 2004, Pages 6-11

  Yamane, Hideo ^a   Takayama, Masahiro ^a   Sunami, Kishiko ^a   Iguchi, Hiroyoshi ^a   Kanazawa, Akimori ^a   Tokuhara, Yasutake ^a   Nishiura, Hiroshi ^a   Nishimurad, Keizou ^a   Shu, Dong Tao ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Cochlea; Glutamate; Inner ear; Morphology; NO

Indexed keywords

3,3 BIS(2 AMINOETHYL) 1 HYDROXY 2 OXOTRIAZENE; NITRIC OXIDE; NITRIC OXIDE DONOR; TRYPAN BLUE; 1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-ISOPROPYL-1-TRIAZENE; 3 (3 AMINOPROPYL) 1 HYDROXY 3 ISOPROPYL 2 OXO 1 TRIAZENE; SCAVENGER; TRIAZENE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; COCHLEA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTI ORGAN; GUINEA PIG; HAIR CELL; INNER EAR DISEASE; NONHUMAN; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; COCHLEA FENESTRA; CYTOLOGY; DRUG EFFECT; ELECTRON MICROSCOPY; METABOLISM; PATHOLOGY; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; COCHLEA; FREE RADICAL SCAVENGERS; GUINEA PIGS; HAIR CELLS, OUTER; MICROSCOPY, ELECTRON; NITRIC OXIDE; ROUND WINDOW; TRIAZENES;

EID: 6044235639     PISSN: 03655237     EISSN: None     Source Type: Journal    
DOI: 10.1080/03655230410018453     Document Type: Article

References (20)

1. Moncada S, Palmer RMJ, Higgs E. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-42.
2. Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovasc Brain Metab Rev 1991; 3: 213-45.
3. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. Nitric oxide mediates glutamate neurotoxicity in primary cultures. Pro Natl Acad Sci USA 1991; 88: 6368-71.
4. Dawson VL, Dawson TM, Bartley DA, et al. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain culture. J Neurosci 1993; 13: 2651-61.
5. Siesjo BK, Bengtsson F. Calcium fluxes, calcium antagonists, and calcium related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab 1989; 9: 127-40.
6. Synder SH. Nitric oxide: First in a new class of neurotransmitters? Science 1992; 257: 494-6.
7. Eybalin M. Neurotransmitters and neuromodulators of the mammalian cochlea. Physiol Rev 1993; 73: 309-73.
8. Pujol R, Lenoir M, Robertson D, Eybalin M, Johnstone BM. Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells. Hear Res 1985; 18: 145-51.
9. Sunami K, Yamane H, Nakgawa T, Takayama M, Konishi K. Glutamate toxicity induced degeneration of outer hair cells with a temporal increase of nitric oxide production in the guinea pig cochlea. Eur Arch Otorhinolaryngol 1999; 256: 323-9.
10. Kong W-J, Ren T, Nuttall AL. Electrophysiological and morphological evaluation of the acute ototoxicity of sodium nitroprusside. Hear Res 1996; 99: 22-30.
11. Yamane H, Konishi K, Iguchi H, Nakagawa T, Shibata S, Takayama M, Nishimura K, Sunami K, Nakai Y. Assessment of hair cell death using the dye extrusion method. Acta Otolaryngol 1998; Suppl 538: 7-11.
12. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1982; 239: 57-69.
13. Morikawa E, Huang Z, Moskowitz MA. L-arginine decreases infarct size caused by MCA occlusion in spontaneously hypertensive rat. Am J Physiol 1992; 263: H1632-5.
14. Hakuba N. Ischemia-induced hearing loss and glutamate efflux in the perilymph; An experimental study in the gerbil. Practica Oto-Rhino-Laryngologica 1998; 91: 313-21.
15. Hess A, Bloch W, Huverstuhl J, Su J, Stennert E, Addicks K, Michel O. Expression of inducible nitric oxide synthase (iNOS/NOS) in the cochlea of guinea pigs after intratympanical endotoxin-treatment. Brain Res 1999; 830: 113-22.
16. Maragos CM, Wang GM, Hrabie JA, Openheim JJ, Keefer LK. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. Cancer Res 1993; 53: 564-8.
17. Choi DW, Maulucci-Gedde, Kriegstein. Gultamate Neurotoxicity in cortical cell culture. J Neurosci 1987; 7: 357-68.
18. Nitatori T, Sato N, Waguri S. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 1995; 15: 1001-11.
19. Deshpande J, Bergstedt K, Linden T, Kalimo H, Wieloch T. Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death. Exp Brain Res 1992; 88: 91-105.
20. Takayama M, Yamane H, Konishi K, Iguchi H, Naagawa T, Shibata S, Nishimura K, Sunami K, Nakai Y. Cleavage product from NO donor NOC-5 and inner ear hair cell damage. Acta Otolaryngol 1998; Suppl 538: 12-8.