Nonylphenol induced apoptosis in rat testis through the Fas/FasL pathway

Bulletin of Environmental Contamination and Toxicology

Volumn 73, Issue 4, 2004, Pages 620-627

  Han, X ^a   Tu, Z ^a   Wang, X ^a   Shen, S ^a   Hou, Y ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; NONYLPHENOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; RAT; RNA ISOLATION; TESTIS; TESTIS DISEASE; UPREGULATION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; ENVIRONMENTAL POLLUTANTS; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; MALE; MEMBRANE GLYCOPROTEINS; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERTOLI CELLS;

ANIMALIA;

EID: 6044234705     PISSN: 00074861     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00128-004-0473-2     Document Type: Article

References (16)

1. Chapin RE, Delaney J, Wang YF, Lanning L, Davis B, Collins B, Mintz N, Wolfe G. (1999) The effects of 4-nonylphenol in rats: A multigeneration reproduction study. Toxicol Sci 52:80-91
2. Christiansen T, Korsgaard B, Jespersen A. (1998) Effects of nonylphenol and 17-beta-oestradiol on vitellogenin synthesis, testicular structure and cytology in male eelpout Zoarces viviparous. J Exp Biol 201:179-192
3. Hossaini A, Dalgaard M, Vinggaard AM, Frandsen H, Larsen JJ. (2001) In utero reproductive study bin rats exposed to nonylphenol. Reprod Toxicol 15:537-43
4. (2+) pumps. Biochem Biophys Res Commun 277:568-574
5. Kinnberg K, Korsgaard B, Bjerregaard P. (2000) Concentration-dependent effects of nonylphenol on testis structure in adult platyfish Xiphophorus maculates. Mar Environ Res 50:169-173
6. Kwack SJ, Kwon O, Kim HS, Kim SS, Kim SH, Sohn KH, Lee RD, Park CH, Jeung EB, An BS, Park KL. (2002) Comparative evaluation of alkylphenolic compounds on estrogenic activity in vitro and in vivo. J Toxicol Environ Health 65:419-431
7. Laurenzana EM, Balasubramanian G, Weis C, Blaydes B, Newbold RR, Delclos KB. (2002) Effect of nonylpheonl on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal, and, adult rats. Chem Biol Interact 139:23-41
8. Lee J, Richburg JH, Younkin SC, Boekelheide K. (1997) The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138:2081-2088
9. Lee J, Richburg JH, Shipp EB, Meistrich ML, Boekelheide K. (1999) The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology 40:852-858
10. Lynn PW, Yiannis K, Gap SH, Arthur JN, David MJ, Chris DM. (2002) Increased cellular apoptosis after chronic aqueous exposure to nonylphenol and quercetin in adult medaka (Oryzias latipes). Comp Biochem Physiol 131:51-59
11. Miles-Richardson SR, Pierens SL, Nichols KM, Kramer VJ, Snyder EM, Snyder SA, Render JA, Fitzgerald SD, Giesy JP. (1999) Effects of waterborne exposure to 4-nonylphenol and nonylphenol ethoxylate on secondary sex characteristics and gonads of fathead minnows (Pimephales promelas). Environ Res 80:8122-8137
12. Nagao T, Wada K, Marumo H, Yoshimura S, Ono H. (2001) Reproductive effects of nonylphenol in rats after gavage administration: a two-generation study. Reprod Toxicol 15:293-315
13. Pineau C, Dupaix A, Jegou B. (1999) The Co-culture of Sertoli Cells and Germs Cells: Application in Toxicology. Toxicol in Vitro 13:513-520
14. Richburg JH. (2000) The relevance of spontaneous- and chemically- induced alterations in testicular germ cell apoptosis to toxicology. Toxicol Lett 15:79-86
15. Sharpe RM. (1998) Toxicity of spermatogenesis and its detection. In: Korach KS. Reproductive and Developmental Toxicology. New York, NY: Marcel Dekker, p625-634
16. Wang X, Han X, Hou Y, Yao G, Wang Y. (2003) Effect of nonylphenol on apoptosis of Sertoli cells in vitro. Environ Contam Toxicol 70:898-904