Senna-induced hepatitis in a poor metabolizer [5]

Annals of Internal Medicine

Volumn 141, Issue 8, 2004, Pages 650-651

  Seybold, Ulrich ^a   Landauer, Nikola ^a   Hillebrand, Susanne ^a   Goebel, Frank Detlef ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6; HEPATITIS A VACCINE; HEPATITIS B VACCINE; SENNA EXTRACT; LAXATIVE;

ADULT; CASE REPORT; CLINICAL FEATURE; CONSTIPATION; DRUG METABOLISM; ECHOGRAPHY; FATIGUE; FEMALE; HEARTBURN; HEPATITIS; HEPATITIS A; HEPATITIS B; HUMAN; LABORATORY TEST; LETTER; LIVER FUNCTION TEST; LIVER METABOLISM; MYALGIA; NAUSEA; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SENNA; TEA; GENETICS; HOMOZYGOTE; TOXIC HEPATITIS;

ADULT; CATHARTICS; CYTOCHROME P-450 CYP2D6; FEMALE; HEPATITIS, TOXIC; HOMOZYGOTE; HUMANS; SENNA EXTRACT;

EID: 6044231023     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-141-8-200410190-00024     Document Type: Letter

References (5)

1. Kobashi K, Nishimura T, Kusaka M, Hattori M, Namba T. Metabolism of sennosides by human intestinal bacteria. Planta Med. 1980;40:225-36. [PMID: 7443842]
2. de Witte P, Lemli L. The metabolism of anthranoid laxarives. Hepatogastroenterology. 1990;37:601-5. [PMID: 2289777]
3. Beuers U, Spengler U, Pape GR. Hepatitis after chronic abuse of senna [Letter]. Lancet. 1991;337:372-3. [PMID: 1671276]
4. Krumbiegel G, Schulz HU. Rhein and aloe-emodin kinetics from senna laxatives in man. Pharmacology. 1993;47 Suppl 1:120-4. [PMID: 8234418]
5. Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997;60:284-95. [PMID: 9012401]