Skin fibroblast model to study an impaired glutathione synthesis: Consequences of a genetic polymorphism on the proteome

Brain Research Bulletin

Volumn 79, Issue 1, 2009, Pages 46-52

  Gysin, René ^a   Riederer, Irène M ^a   Cuénod, Michel ^a   Do, Kim Q ^a   Riederer, Beat M ^a,b  

^a University Hospital Center   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

GCLC GAG trinucleotide repeat; Glutamate cysteine ligase; Glutathione; Oxidative stress; Skin fibroblast cultures; Two dimensional gel electrophoresis

Indexed keywords

GAG PROTEIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; PROTEOME; TERT BUTYLHYDROQUINONE;

ADULT; ARTICLE; CELL FUNCTION; CYTOSKELETON; DNA POLYMORPHISM; ENERGY METABOLISM; FEMALE; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MENTAL DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; SKIN BIOPSY; SKIN FIBROBLAST; TRINUCLEOTIDE REPEAT;

ADULT; ANTIOXIDANTS; BIOPSY; BLOTTING, WESTERN; CELLS, CULTURED; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; FIBROBLASTS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; HYDROQUINONES; MALE; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; PROTEOME; SCHIZOPHRENIA; SEQUENCE ANALYSIS, DNA; SKIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRINUCLEOTIDE REPEATS;

EID: 60249096671     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2008.10.015     Document Type: Article

References (38)

1. Aragno M., Mastrocola R., Medana C., Restivo F., Catalano M.G., Pons N., Danni O., and Boccuzzi G. Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment. Endocrinology 146 (2005) 5561-5567
2. Arckens L., Van der G.E., Van den B.G., Massie A., Leysen I., Vandenbussche E., Eysel U.T., Huybrechts R., and Vandesande F. Differential display implicates cyclophilin A in adult cortical plasticity. Eur. J. Neurosci. 18 (2003) 61-75
3. Beard K.M., Shangari N., Wu B., and O'Brien P.J. Metabolism, not autoxidation, plays a role in alpha-oxoaldehyde- and reducing sugar-induced erythrocyte GSH depletion: relevance for diabetes mellitus. Mol. Cell Biochem. 252 (2003) 331-338
4. Beasley C.L., Pennington K., Behan A., Wait R., Dunn M.J., and Cotter D. Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes. Proteomics 6 (2006) 3414-3425
5. Bekris L.M., Shephard C., Janer M., Graham J., McNeney B., Shin J., Zarghami M., Griffith W., Farin F., Kavanagh T.J., and Lernmark A. Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels. Exp. Clin. Endocrinol. Diabetes 115 (2007) 221-228
6. Beutler E., Gelbart T., Kondo T., and Matsunaga A.T. The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. Blood 94 (1999) 2890-2894
7. Beutler E., Scott S., Bishop A., Margolis N., Matsumoto F., and Kuhl W. Red cell aldolase deficiency and hemolytic anemia: a new syndrome. Trans. Assoc. Am. Physicians 86 (1973) 154-166
8. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
9. Clark D., Dedova I., Cordwell S., and Matsumoto I. A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Mol. Psychiatry 11 459-70 (2006) 423
10. Conway J.P., and Kinter M. Dual role of peroxiredoxin I in macrophage-derived foam cells. J. Biol. Chem. 281 (2006) 27991-28001
11. Cueille N., Blanc C.T., Riederer I.M., and Riederer B.M. Microtubule-associated protein 1B binds glyceraldehyde-3-phosphate dehydrogenase. J. Proteome. Res. 6 (2007) 2640-2647
12. Doyle V., Virji S., and Crompton M. Evidence that cyclophilin-A protects cells against oxidative stress. Biochem. J. 341 Pt 1 (1999) 127-132
13. Elekes O., Venema K., Postema F., Dringen R., Hamprecht B., and Korf J. Evidence that stress activates glial lactate formation in vivo assessed with rat hippocampus lactography. Neurosci. Lett. 208 (1996) 69-72
14. Evans J.L., Goldfine I.D., Maddux B.A., and Grodsky G.M. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23 (2002) 599-622
15. Gillett G.T., Fox M.F., Rowe P.S., Casimir C.M., and Povey S. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. Ann. Hum. Genet. 60 (1996) 201-211
16. Gysin R., Kraftsik R., Sandell J., Bovet P., Chappuis C., Conus P., Deppen P., Preisig M., Ruiz V., Steullet P., Tosic M., Werge T., Cuenod M., and Do K.Q. Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 16621-16626
17. Hurst J.A., Baraitser M., and Winter R.M. A syndrome of mental retardation, short stature, hemolytic anemia, delayed puberty, and abnormal facial appearance: similarities to a report of aldolase A deficiency. Am. J. Med. Genet. 28 (1987) 965-970
18. Johnston-Wilson N.L., Sims C.D., Hofmann J.P., Anderson L., Shore A.D., Torrey E.F., and Yolken R.H. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Mol. Psychiatry 5 (2000) 142-149
19. Kishi H., Mukai T., Hirono A., Fujii H., Miwa S., and Hori K. Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 8623-8627
20. Koide S., Kugiyama K., Sugiyama S., Nakamura S., Fukushima H., Honda O., Yoshimura M., and Ogawa H. Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction. J. Am. Coll. Cardiol. 41 (2003) 539-545
21. Korolainen M.A., Goldsteins G., Nyman T.A., Alafuzoff I., Koistinaho J., and Pirttila T. Oxidative modification of proteins in the frontal cortex of Alzheimer's disease brain. Neurobiol. Aging 27 (2006) 42-53
22. Luban J., Bossolt K.L., Franke E.K., Kalpana G.V., and Goff S.P. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 73 (1993) 1067-1078
23. Masuda H., Tanaka K., Takagi M., Ohgami K., Sakamaki T., Shibata N., and Takahashi K. Molecular cloning and characterization of human non-smooth muscle calponin. J. Biochem. (Tokyo) 120 (1996) 415-424
24. McKone E.F., Shao J., Frangolias D.D., Keener C.L., Shephard C.A., Farin F.M., Tonelli M.R., Pare P.D., Sandford A.J., Aitken M.L., and Kavanagh T.J. Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. Am. J. Respir. Crit. Care Med. 174 (2006) 415-419
25. Meister A. Glutathione biosynthesis and its inhibition. Methods Enzymol. 252 (1995) 26-30
26. Mirnics K., Levitt P., and Lewis D.A. Critical appraisal of DNA microarrays in psychiatric genomics. Biol. Psychiatry 60 (2006) 163-176
27. Miwa S., Fujii H., Tani K., Takahashi K., Takegawa S., Fujinami N., Sakurai M., Kubo M., Tanimoto Y., Kato T., and Matsumoto N. Two cases of red cell aldolase deficiency associated with hereditary hemolytic anemia in a Japanese family. Am. J. Hematol. 11 (1981) 425-437
28. Neumann C.A., Krause D.S., Carman C.V., Das S., Dubey D.P., Abraham J.L., Bronson R.T., Fujiwara Y., Orkin S.H., and Van Etten R.A. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424 (2003) 561-565
29. Porchet R., Probst A., Bouras C., Draberova E., Draber P., and Riederer B.M. Analysis of glial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease. Proteomics 3 (2003) 1476-1485
30. Prestera T., Holtzclaw W.D., Zhang Y., and Talalay P. Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 2965-2969
31. Shaw M.M., and Riederer B.M. Sample preparation for two-dimensional gel electrophoresis. Proteomics 3 (2003) 1408-1417
32. Soares A.F., Guichardant M., Cozzone D., Bernoud-Hubac N., Bouzaidi-Tiali N., Lagarde M., and Geloen A. Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes. Free Radic. Biol. Med. 38 (2005) 882-889
33. Soltaninassab S.R., Sekhar K.R., Meredith M.J., and Freeman M.L. Multi-faceted regulation of gamma-glutamylcysteine synthetase. J. Cell. Physiol. 182 (2000) 163-170
34. Tosic M., Ott J., Barral S., Bovet P., Deppen P., Gheorghita F., Matthey M.L., Parnas J., Preisig M., Saraga M., Solida A., Timm S., Wang A.G., Werge T., Cuenod M., and Do K.Q. Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene. Am. J. Hum. Genet. 79 (2006) 586-592
35. Walsh A.C., Feulner J.A., and Reilly A. Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel. Toxicol. Sci. 61 (2001) 218-223
36. Walsh A.C., Li W., Rosen D.R., and Lawrence D.A. Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5′ untranslated region. Cytogenet. Cell Genet. 75 (1996) 14-16
37. White C.C., Viernes H., Krejsa C.M., Botta D., and Kavanagh T.J. Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity. Anal. Biochem. 318 (2003) 175-180
38. Yount G.L., Gall C.M., and White J.D. Limbic seizures increase cyclophilin mRNA levels in rat hippocampus. Brain Res. Mol. Brain Res. 14 (1992) 139-142