Comparison of hypotensive and hypolipidemic effects of Catharanthus roseus leaves extract with nifedipine on adrenaline induced hypertensive rats

Journal of Biological Sciences

Volumn 8, Issue 6, 2008, Pages 1082-1086

  Ara, N ^a   Rashid, M ^a   Amran, Md Shah ^b  

^a UNIVERSITY OF RAJSHAHI   (Bangladesh)

^b UNIVERSITY OF DHAKA   (Bangladesh)

Author keywords

Adrenaline; Antihypertensive; Catharanthus roseus; Hypertension; Nifedipine

Indexed keywords

ADRENALIN; CATHARANTHUS ROSEUS EXTRACT; CHOLESTEROL; GLUCOSE; LIPID; NIFEDIPINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BLOOD PRESSURE REGULATION; BODY WEIGHT; CATHARANTHUS ROSEUS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; DRUG PURIFICATION; GLUCOSE BLOOD LEVEL; HEART WEIGHT; HYPERTENSION; MORNING DOSAGE; NONHUMAN; PLANT LEAF; RAT; SINGLE DRUG DOSE; SPECTROSCOPY; TREATMENT DURATION; TREATMENT OUTCOME;

ANIMALIA; CATHARANTHUS ROSEUS; RATTUS;

EID: 60249094381     PISSN: 17273048     EISSN: 18125719     Source Type: Journal    
DOI: 10.3923/jbs.2008.1082.1086     Document Type: Article

References (10)

1. Amran, M.S., K. Hashmito and N. Homma, 2004. Effects of sodium-calcium exchange inhibitors. J. Pharmacol. Exp. Ther., 310: 83-89.
2. Antia, B.S. and J.E. Okokon, 2005. Effect of leaf juice of Catharanthus roseus Linn on cholesterol, triglyceride and lipoproteins levels in normal rats. Indian J. Pharmacol., 37: 401-402.
3. Boosen, E.I., W.P. Andersion and M.K. Michelle, 2005. Role of endothelin in noradrenaline-induced hypertension in rats. J. Hyperten., 23: 987-993.
4. Dupuis, F., A. Jeffrey, L. Patrick and J.M. Chillon, 2005. Comparative effects of the angiotensin II receptor blocker, telmisartan and the angiotensin-converting enzyme inhibitor, ramipril, on cerebrovascular structure in spontaneously hypertensive rats. J. Hyperten, 23: 1061-1066.
5. Gillman, A.G., T.W. Rall, A. Nies and P. Taylor, 1990. Goodman and Gilmans's the Pharmacological Basis of Therapeutics. 8th Edn., Pergamon Press, New York, ISBN: 0-02-946568-0, pp: 749-806.
6. Miyata, T., 2007. Pharmacological basis of traditional medicines and health supplements as curatives. J. Pharmacol. Sci., 103: 127-131.
7. Nammi, S., M.K. Boini, S.D. Lodagala and R.B.S. Behara, 2003. The juice of fresh leaves of Catharanthus roseus Linn. Reduces blood glucose in normal and alloxan diabetic rabbits. Biomed. Central, 3: 1-4.
8. Nikkon, F., Z.A. Saud, M.H. Rahman and M.E. Haque, 2003. In vitro Antimicrobial activity of the compound isolated from chloroform extract of Moringa oleifera Lam. Pak. J. Biol. Sci., 6: 1888-1890.
9. Setoguchi, Y., T. Ohnuki, M. Rashid, T. Nakamura and K. Hattori et al., 2002. Effects of chronic administration of sarpogrelate on systolic Blood Pressure on spontaneously hypertensive rats: Comparison with Quinapril. Pharmacology, 64: 71-75.
10. Singh, S.N., P. Vats, S. Suri, R. Shyam and M.M. Kumria et al., 2001. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats J. Ethnopharmacol., 76: 269-277.