An evaluation of toxicity and mutagenicity of Sphenocentrum jollyanum

International Journal of Pharmacology

Volumn 4, Issue 2, 2008, Pages 67-77

  Amidu, Nafiu ^a   Woode, Eric ^a   Owiredu, K B A William ^a   Asare, A George ^b   Baoteng, A Kofi ^a   Opoku Okrah, Clement ^a  

^a KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

Ames test; Chronic toxicity; F344 rats; Sphenocentrum jollyanum

Indexed keywords

PENTOBARBITAL; PLANT EXTRACT; SPHENOCENTRUM JOLLYANUM EXTRACT; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; ENZYME ANALYSIS; FISCHER 344 RAT; LIVER LEVEL; MALE; MEDICINAL PLANT; MUTAGENICITY; NONHUMAN; ORGAN WEIGHT; PLANT ROOT; RAT; SALMONELLA TYPHIMURIUM; SLEEP TIME; SPHENOCENTRUM JOLLYANUM; TOXICITY TESTING;

EID: 60249088177     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2008.67.77     Document Type: Article

References (27)

1. Abbiw, D.K., 1990. Useful Plants of Ghana. Intermediate Technology Publications and Royal Botanic Gardens Kew.
2. Anjum, F., A. Raman, A.R. Shakoori and J.W. Gorrod, 1992. An assessment of cadmium toxicity on cytochrome P-450 and flavin monooxygenase-mediated metabolic pathways of dimethylaniline in male rabbits. J. Environ. Pathol. Toxicol. Oncol., 11(4): 191-195.
3. Baliga, M.S., G.C. Jagetia, J.N. Ulloor, M.P. Baliga, P. Venkatesh, R. Reddy, K.V. Rao, B.S. Baliga, S. Devi, S.K. Raju, V. Veeresh, T.K. Reddy and K.L. Bairy, 2004. The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats. Toxicol. Lett., 151 (2): 317-326.
4. Borzelleca, J.F., 1996. A proposed model for safety assessment of macronutrient substitutes. Regul. Toxicol. Pharmacol., 23 (1 Pt 2): S15-S18.
5. Bruneton, J., 1995. Pharmacognosy, Phytochemistry and Medicinal Plants. Intercept Ltd., England, UK.
6. Gilbert, J.N.T., D.W. Mathieson and M.B. Patel, 1967. The bitter principle of Sphenocentrum jollyanum. Phytochemistry, 6 (1): 135-136.
7. Gonzalez, F. J., 1988. The molecular biology of cytochrome P-450s. Pharmacol. Rev., 40 (4): 243-288.
8. Gonzalez, F.J., 1990. Molecular genetics of the P-450 superfamily. Pharmacol. Ther., 45 (1): 1-38.
9. Guengerich, F.P., 1992. Characterization of human cytochrome P-450 enzymes. FASEB. J., 6 (2):745-748.
10. Husemann, A., 1871. Die Pflanzenstoffe. Berlin.
11. Iwu, M.M., 1993. Handbook of African Medicinal Plants. CRC Press Inc., pp: 239.
12. Lake, B.G., 1987. Preparation and Characterization of Microsomal Fractions for Studies on Xenobiotic Metabolism. In: Biochemical Toxicology: A Practical Approach, Snell, K. and B. Mullock (Eds.). IRL Press, Washington DC., pp: 183-215.
13. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R. J. Randall, 1951. Protein measurement with the foli phenol reagent. J. Biol. Chem., 193 (1): 265-275.
14. Maron, D.M. and B.N. Ames, 1983. Revised methods for the Salmonella mutagenicity test. Mutat. Res., 113 (3-4): 173-215.
15. Massey, A.C., 1992. Microcytic anemia: Differential diagnosis and management of iron deficiency anemia. Med. Clin North Am., 76: 549-566.
16. McManus, J.F.A. and R.W. Mowry, 1965. General Methods for Study of Cell and its Structure. In: Staining Methods: Histologic and Histochemical, McManus, J.F.A. and R.W. Mowry (Eds.). Harper Bros, New York pp: 73-90.
17. Moody, J.O., V.A. Robert, J.D. Connolly and P.J. Houghton, 2006. Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae). J. Ethnopharmacol., 104 (1-2): 87-91.
18. Mortelmans, K. and E. Zelger, 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res., 455 (1-2): 29-60.
19. Nia, R., D.H. Paper, E.E. Essien, K.C. Iyadi, A.I.L. Bassey, A.B. Antai and G. Franz, 2004. Evaluation of the anti-oxidant and anti-angiogenic effects of Sphenocentrum jollyanum Pierre. Afr. J. Biomed. Res., 7: 129-132.
20. Odebiyi, O.O. and E.A. Sofowora, 1978. Phytochemical screening of Nigerian medicinal plants II. Lloydia, 41 (3): 234-246.
21. Omura, T. and R. Sato, 1964. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem., 239: 2370-2378.
22. Owiredu, W.K.B.A., N. Amidu, F. Amissah and E. Woode, 2007. The effects of ethanolic extract of root of Sphenocentrum jollyanum pierre on sexual behaviour and hormonal levels in rodents. J. Sci. Technol., 27 (2): 9-21.
23. Philardeau, Y. and M.M. Debray, 1965. Note Preliminaire Sur Les Alcaloides De Sphenocentrum jollyanum. Rapport Roneeo ORSTOM. In: Plantes Medicinales De La Cote D'lvoire, Bouquet A. and, M. Debray (Eds.). Paris, pp: 115.
24. Raji, Y., O.O. Fadare, R.A. Adisa and S.A. Salami, 2006. Comprehensive assessment of the effect of Sphenocentrum jollyanum root extract on male reproductive activity in albino rats. Reprod. Med. Biol., 5 (4): 283-292.
25. Smolenski, S.J., H. Silinis and N.R. Farnsworth, 1975. Alkaloid screening. VI. Lloydia, 38 (3): 225-255.
26. Trease, G.E. and W.C. Evans, 1989. A Textbook of Pharmacognosy. 13th Edn. Bailliere Tindall Ltd., London.
27. Woode, E., M. Duwiejua, C. Ansah, G.A. Kuffour, D.D. Obiri and N. Amidu, 2006. Effect of Sphenocentrum jollyanum in experimental mouse models of anxiety. In: Proceedings of the 2nd Western Africa Network of Natural Products Research Scientists (WANNPRES), Vol. 32. Elmina, Ghana, pp: 32.