Inhibitory effect of HMGN2 protein on human hepatitis B virus expression and replication in the HepG2.2.15 cell line

Antiviral Research

Volumn 81, Issue 3, 2009, Pages 277-282

  Feng, Yun ^a   He, Fang ^b   Zhang, Ping ^a   Wu, Qi ^b   Huang, Ning ^b   Tang, Hong ^b   Kong, Xiangli ^a   Li, Yan ^a   Lu, Junju ^a   Chen, Qianming ^a   Wang, Boyao ^b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Antiviral activity; HepG2.2.15 cell line; HMGN2; Human hepatitis B virus

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; HIGH MOBILITY GROUP N2 PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; VIRUS EXPRESSION; VIRUS REPLICATION;

BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CELL LINE; CELL SURVIVAL; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, VIRAL; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; HMGN2 PROTEIN; HUMANS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, VIRAL; VIRUS REPLICATION;

HEPATITIS B VIRUS;

EID: 60249084993     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2008.12.011     Document Type: Article

References (36)

1. Ayer L.M., Rubin R.L., Dixon G.H., and Fritzler M.J. Antibodies to HMG proteins in patients with drug-induced autoimmunity. Arthritis. Rheum. 37 (1994) 98-103
2. Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol. Cell. Biol. 19 (1999) 5237-5246
3. Bustin M., Reisch J., Einck L., and Klippel J.H. Autoantibodies to nucleosomal proteins: antibodies to HMG-17 in autoimmune diseases. Science 215 (1982) 1245-1247
4. Carlo F., Gabriele M., Carolina B., and Simona U. Immunopathogenesis of hepatitis B. J. Hepatol. 39 (2003) S36-S42
5. Chisari F.V. Hepatitis B virus transgenic mice: insights into the virus and the disease. Hepatology 22 (1995) 1316-1325
6. Czura C.J., Wang H., and Tracey K.J. Dual roles for HMGB1: DNA binding and cytokine. J. Endotoxin Res. 7 (2001) 315-321
7. Feng Y., Huang N., Wu Q., and Wang B. HMGN2: a novel antimicrobial effector molecule of human mononuclear leukocytes?. J. Leukoc. Biol. 78 (2005) 1136-1141
8. Fernandes J.M.O., Saint N., Kemp G.D., and Smith V.J. Oncoryncin III: a potent antimicrobial peptide derived from the nonhistone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss. J. Biochem. 373 (2003) 621-628
9. Ganz T., Selsted M.E., Szklarek D., Harwig S.S.L., Daher K., Bainton D.F., and Lehrer R.I. Defensins, natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76 (1985) 1427-1435
10. Guidotti L.G., Ishikawa T., Hobbs M.V., Matzke B., Schreiber R., and Chisari F.V. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4 (1996) 25-36
11. Harwig S.S., Chen N.P., Park A.S., and Lehrer R.L. Purification of cysteine-rich bioactive peptides from leukocytes by continuous acid-urea-polyacrylamide gel electrophoresis. Anal. Biochem. 208 (1993) 382-386
12. Hock R., Wilde F., Scheer U., and Bustin M. Dynamicr relocation of chromosomal protein HMG-17 in the nucleusis is dependent on transcriptional activity. EMBO J. 17 (1998) 6992-7001
13. Lacey S.F., Weinhold K.J., Chen C.H., McDanal C., Oei C., and Greenberg M.L. Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual. AIDS Res. Hum. Retroviruses 14 (1998) 521-531
14. Landsman D., McBride O.W., and Bustin M. Human non-histone chromosomal protein HMG-17: identification, characterization, chromosome localization and RFLPs of a functional gene from the large multigene family. Nucleic Acids Res. 17 (1989) 2301-2314
15. Landsman D., Soares N., Gonzalez F.J., and Bustin M. Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family. J. Biol. Chem. 261 (1986) 7479-7484
16. Lehrer R.I., Rosenman M., Harwig S.S., Jackson R., and Eisenhauer P. Ultrasensitive assays for endogenous antimicrobial polypeptides. J. Immunol. Methods 137 (1991) 167-173
17. Levy J.A., Mackewicz C.E., and Barker E. Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells. Immunol. Today 17 (1996) 214-217
18. Lin X., Yuan Z.H., Wu L.L., Ding J.P., and Wen Y.M. A single amino acid in the reverse transcriptase domain of hepatitis B virus affects virus replication efficiency. J. Virol. 75 (2001) 11827-11833
19. Ming L., Xiaoling P., Yan L., Lili W., Qi W., Xiyong Y., Boyao W., and Ning H. Purification of antimicrobial factors from human cervical mucus. Hum. Reprod. 22 (2007) 1810-1815
20. Mosoian A., Teixeira A., Caron E., Piwoz J., and Klotman M.E. CD8+ cell lines isolated from HIV-1-infected children have potent soluble HIV-1 inhibitory activity that differs from beta-chemokines. Viral Immunol. 13 (2000) 481-495
21. Okamura S., Ng C.C., Koyama K., Takei Y., Arakawa H., Monden M., and Nakamura Y. Identification of seven genes regulated by wild-type p53 in a colon cancer cell line carrying a well-controlled wild-type p53 expression system. Oncol. Res. 11 (1999) 281-285
22. Panyim S., and Chalkley R. High resolution acrylamide gel electrophoresis of histones. Arch. Biochem. Biophys. 130 (1969) 337-346
23. Paranjape S.M., Krumm A., and Kadonaga J.T. HMG17 is a chromatin-specific transcriptional coactivator that increases the efficiency of transcription initiation. Genes Dev. 9 (1995) 1978-1991
24. Popescu N., Landsman D., and Bustin M. Mapping the human gene coding for chromosomal protein HMG-17. Hum. Genet. 85 (1990) 376-378
25. Ren X.R., Zhou L.J., Luo G.B., Lin B., and Xu A. Inhibition of hepatitis B virus replication in 2.2.15 cells by expressed shRNA. J. Viral Hepat. 12 (2005) 236-242
26. Schägger H., and von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166 (1987) 368-379
27. Spieker N., Beitsma M., van Sluis P., Roobeek I., den Dunnen J.T., Speleman F., Caron H., and Versteeg R. An integrated 5-Mb physical, genetic, and radiation hybrid map of a 1p36.1 region implicated in neuroblastoma pathogenesis. Genes Chromosomes Cancer 27 (2000) 143-152
28. Srikantha T., Landsman D., and Bustin M. Retropseudogenes for human chromosomal protein HMG-17. J. Mol. Biol. 197 (1987) 405-413
29. Tremethick D.J., and Hyman L. High mobility group protein 14 and 17 can prevent the close packing of nucleosomes by increasing the strength of protein contacts in the linker DNA. J. Biol. Chem. 271 (1996) 12009-12016
30. Vestner B., Bustin M., and Gruss C. Stimulation of replication efficiency of a chromatin template by chromosomal protein HMG-17. J. Biol. Chem. 273 (1998) 9409-9414
31. Vlachoyiannopoulos P.G., Boumba V.A., Tzioufas A.G., Seferiadis C., Tsolas O., and Moutsopoulos H.M. Autoantibodies to HMG-17 nucleosomal protein in patients with scleroderma. J. Autoimmun. 7 (1994) 193-201
32. Walker C.M., Moody D.J., Stites D.P., and Levy J.A. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234 (1986) 1563-1566
33. Wenbi X., Yun F., Guoxing W., Ning H., Qi W., Xuan L., and Boyao W. Production of HMGN polyclonal antibody by immunization with recombinant GST HMGN fusion protein and its application to analysis of HMGN distribution in human monocytes. J. Sichuan Univ. (Med. Sci. Edi. ) 364 (2005) 451-455
34. Yang H., Wang H., and Tracey K.J. HMG-1 rediscovered as a cytokine. Shock 15 (2001) 247-253
35. Zetterström C.K., Strand M.L., and Söder O. The high mobility group box chromosomal protein 1 is expressed in the human and rat testis where it may function as an antibacterial factor. Hum. Reprod. 21 (2006) 2801-2809
36. Zhang L., Yu W., He T., Yu J., Caffrey R.E., Dalmasso E.A., Fu S., Pham T., Mei J., Ho J.J., Zhang W., Lopez P., and Ho D.D. Contribution of human α-defensin 1, 2 and 3 to the anti-HIV activity of CD8 antiviral factor. Science 298 (2002) 995-999