Exceptional genetic variability of hepatitis B virus indicates that Rwanda is east of an emerging African genotype E/A1 divide

Journal of Medical Virology

Volumn 81, Issue 3, 2009, Pages 435-440

  Hübschen, Judith M ^a   Mugabo, Jules ^b   Peltier, Cécile Alexandra ^c   Karasi, Jean Claude ^d   Sausy, Aurélie ^a   Kirpach, Pierre ^e   Arendt, Vic ^e   Muller, Claude P ^a  

^a LABORATOIRE NATIONAL DE SANTÉ   (Luxembourg)

^b Treatment and Research AIDS Center   (Rwanda)

^c Lux Development   (Rwanda)

^d Retrovirology Laboratory Luxembourg   (Luxembourg)

^e CENTRE HOSPITALIER DE LUXEMBOURG   (Luxembourg)

Author keywords

Genotyping; Molecular epidemiology; Phylogeny

Indexed keywords

AFRICA; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MAJOR CLINICAL STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; RWANDA; UNINDEXED SEQUENCE; VIRUS GENOME; VIRUS STRAIN; CHEMISTRY; CLASSIFICATION; CLUSTER ANALYSIS; DNA SEQUENCE; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; PREGNANT WOMAN; VIROLOGY;

HEPATITIS B VIRUS;

VIRUS DNA;

CLUSTER ANALYSIS; DNA, VIRAL; FEMALE; GENETIC VARIATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; MOLECULAR SEQUENCE DATA; PHYLOGENY; PREGNANT WOMEN; RWANDA; SEQUENCE ANALYSIS, DNA;

EID: 60049093144     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21412     Document Type: Article

References (34)

1. Bekondi C, Olinger CM, Boua N, Talarmin A, Muller CP, Le Faou A, Venard V. 2007. Central African Republic is part of the West-African hepatitis B virus genotype E crescent. J Clin Virol 40:31-37.
2. Bowyer SM, van Staden L, Kew MC, Sim JG. 1997. A unique segment of the hepatitis B virus group A genotype identified in isolates from South Africa. J Gen Virol 78:1719-1729.
3. Candotti D, Opare-Sem O, Rezvan H, Sarkodie F, Allain JP. 2006. Molecular and serological characterization of hepatitis B virus in deferred Ghanaian blood donors with and without elevated alanine aminotransferase. J Viral Hepat 13:715-724.
4. Carman WF, Jazayeri M, Basuni A, Thomas HC, Karayiannis P. 2005. Hepatitis B surface antigen (HBsAg) variants. In: Thomas HC, Lemon SM, Zuckerman AJ, editors. Viral hepatitis 3rd edition. Oxford, UK: Blackwell Publishing Ltd. pp 225-241.
5. Chan HL, Tsui SK, Tse CH, Ng EY, Au TC, Yuen L, Bartholomeusz A, Leung KS, Lee KH, Locarnini S, Sung JJ. 2005. Epidemiological and virological characteristics of 2 subgroups of hepatitis B virus genotype C. J Infect Dis 191:2022-2032.
6. Dumpis U, Mendy M, Hill A, Thursz M, Hall A, Whittle H, Karayiannis P. 2001. Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers. J Med Virol 65:664-670.
7. Hannoun C, Soderstrom A, Norkrans G, Lindh M. 2005. Phylogeny of African complete genomes reveals a West African genotype A subtype of hepatitis B virus and relatedness between Somali and Asian A1 sequences. J Gen Virol 86:2163-2167.
8. Huy TT, Ushijima H, Quang VX, Win KM, Luengrojanakul P, Kikuchi K, Sata T, Abe K. 2004. Genotype C of hepatitis B virus can be classified into at least two subgroups. J Gen Virol 85:283-292.
9. Jutavijittum P, Olinger CM, Hübschen JM, Yousukh A, Samountry B, Thammavong T, Toriyama K, Muller CP. 2007. Molecular phylogeny of hepatitis B in Lao PDR reveals multiple subtypes of endemic genotypes, a growing prevalence of recombinations within sub- and genotypes and a potential new genotype. 2007 International Meeting The Molecular Biology of Hepatitis B Viruses. Rome, Italy.
10. Kew MC, Kramvis A, Yu MC, Arakawa K, Hodkinson J. 2005. Increased hepatocarcinogenic potential of hepatitis B virus genotype A in Bantu-speaking sub-Saharan Africans. J Med Virol 75:513-521.
11. Kimbi GC, Kramvis A, Kew MC. 2004. Distinctive sequence characteristics of subgenotype A1 isolates of hepatitis B virus from South Africa. J Gen Virol 85:1211-1220.
12. Kramvis A, Kew MC. 2007a. Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes. Hepatol Res 37:S9-S19.
13. Kramvis A, Kew MC. 2007b. Molecular characterization of subgenotype A1 (subgroup Aa) of hepatitis B virus. Hepatol Res 37:S27-S32.
14. Kramvis A, Weitzmann L, Owiredu WK, Kew MC. 2002. Analysis of the complete genome of subgroup A′ hepatitis B virus isolates from South Africa. J Gen Virol 83:835-839.
15. Kumar S, Tamura K, Nei M. 2004. MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 5:150-163.
16. Kurbanov F, Tanaka Y, Fujiwara K, Sugauchi F, Mbanya D, Zekeng L, Ndembi N, Ngansop C, Kaptue L, Miura T, Ido E, Hayami M, Ichimura H, Mizokami M. 2005. A new subtype (subgenotype) Ac (A3) of hepatitis B virus and recombination between genotypes A and E in Cameroon. J Gen Virol 86:2047-2056.
17. Makuwa M, Souquiere S, Telfer P, Apetrei C, Vray M, Bedjabaga I, Mouinga-Ondeme A, Onanga R, Marx PA, Kazanji M, Roques P, Simon F. 2006. Identification of hepatitis B virus subgenotype A3 in rural Gabon. J Med Virol 78:1175-1184.
18. Mulders MN, Venard V, Njayou M, Edorh AP, Bola Oyefolu AO, Kehinde MO, Muyembe Tamfum JJ, Nebie YK, Maiga I, Ammerlaan W, Fack F, Omilabu SA, Le Faou A, Muller CP. 2004. Low genetic diversity despite hyperendemicity of hepatitis B virus genotype E throughout West Africa. J Infect Dis 190:400-408.
19. Norder H, Hammas B, Lee SD, Bile K, Courouce AM, Mushahwar IK, Magnius LO. 1993. Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen. J Gen Virol 74:1341-1348.
20. Norder H, Courouce AM, Coursaget P, Echevarria JM, Lee SD, Mushahwar IK, Robertson BH, Locarnini S, Magnius LO. 2004. Genetic diversity of hepatitis B virus strains derived worldwide: Genotypes, subgenotypes, and HBsAg subtypes. Intervirology 47:289-309.
21. Okamoto H, Imai M, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M. 1987. Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr. J Virol 61:3030-3034.
22. Olinger CM, Venard V, Njayou M, Oyefolu AO, Maiga I, Kemp AJ, Omilabu SA, le Faou A, Muller CP. 2006. Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: New subtypes, mixed infections and recombinations. J Gen Virol 87:1163-1173.
23. Olinger CM, Jutavijittum P, Hübschen JM, Yousukh A, Samountry B, Thammavong T, Toriyama K, Muller CP. 2008 Possible new hepatitis B virus genotype, southeast Asia. Emerg Infect Dis 14:1777-1780.
24. Pawlotsky JM, Tsakiris L, Roudot-Thoraval F, Pellet C, Stuyver L, Duval J, Dhumeaux D. 1995. Relationship between hepatitis C virus genotypes and sources of infection in patients with chronic hepatitis C. J Infect Dis 171:1607-1610.
25. Pirillo MF, Bassani L, Germinario EA, Mancini MG, Vyankandondera J, Okong P, Vella S, Giuliano M. 2007. Seroprevalence of hepatitis B and C viruses among HIV-infected pregnant women in Uganda and Rwanda. J Med Virol 79:1797-1801.
26. Stuyver L, De Gendt S, Van Geyt C, Zoulim F, Fried M, Schinazi RF, Rossau R. 2000. A new genotype of hepatitis B virus: Complete genome and phylogenetic relatedness. J Gen Virol 81:67-74.
27. Sugauchi F, Orito E, Kato H, Suzuki S, Kawakita S, Sakamoto Y, Fukushima K, Akiba T, Yoshihara N, Ueda R, Mizokami M. 2003. Genotype, serotype, and phylogenetic characterization of the complete genome sequence of hepatitis B virus isolates from Malawian chronic carriers of the virus. J Med Virol 69:33-40.
28. Suzuki S, Sugauchi F, Orito E, Kato H, Usuda S, Siransy L, Arita I, Sakamoto Y, Yoshihara N, El-Gohary A, Ueda R, Mizokami M. 2003. Distribution of hepatitis B virus (HBV) genotypes among HBV carriers in the Cote d'Ivoire: Complete genome sequence and phylogenetic relatedness of HBV genotype E. J Med Virol 69:459-465.
29. Tanaka Y, Orito E, Yuen MF, Mukaide M, Sugauchi F, Ito K, Ozasa A, Sakamoto T, Kurbanov F, Lai CL, Mizokami M. 2005. Two subtypes (subgenotypes) of hepatitis B virus genotype C: A novel subtyping assay based on restriction fragment length polymorphism. Hepatol Res 33:216-224.
30. Tran TT, Trinh TN, Abe K. 2008. New complex recombinant genotype of hepatitis B virus identified in Vietnam. J Virol 82:5657-5663.
31. Weber B, Bayer A, Kirch P, Schluter V, Schlieper D, Melchior W. 1999. Improved detection of hepatitis B virus surface antigen by a new rapid automated assay. J Clin Microbiol 37:2639-2647.
32. WHO. 2000. Hepatitis B fact sheet.
33. Zekri AR, Hafez MM, Mohamed NI, Hassan ZK, El-Sayed MH, Khaled MM, Mansour T. 2007. Hepatitis B virus (HBV) genotypes in Egyptian pediatric cancer patients with acute and chronic active HBV infection. Virol J 4:74.
34. Zuckerman JN, Zuckerman AJ. 2003. Mutations of the surface protein of hepatitis B virus. Antiviral Res 60:75-78.