Fighting the "Fire" of Myocardial Reperfusion Injury. How to Define Success?

Journal of the American College of Cardiology

Volumn 53, Issue 8, 2009, Pages 730-731

  Wu, Katherine C ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

cardiac magnetic resonance imaging; microvascular obstruction; myocardial reperfusion injury

Indexed keywords

CADHERIN; FIBRIN DERIVATIVE; FX 06; GADOLINIUM; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; CONTRAST ENHANCEMENT; DRUG MECHANISM; EDITORIAL; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; REPERFUSION INJURY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ST SEGMENT ELEVATION;

ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; COMBINED MODALITY THERAPY; CONTRAST MEDIA; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; GADOLINIUM; HUMANS; INJECTIONS, INTRAVENOUS; MAGNETIC RESONANCE IMAGING; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NECROSIS; PEPTIDE FRAGMENTS;

EID: 60049089538     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2009.01.002     Document Type: Editorial

References (14)

1. Jennings R.B., Sommers H.M., Smyth G.A., et al. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol 70 (1960) 68-78
2. Braunwald E., and Kloner R.A. Myocardial reperfusion: a double-edged sword?. J Clin Invest 76 (1985) 1713-1719
3. Yellon D.M., and Hausenloy D.J. Myocardial reperfusion injury. N Engl J Med 357 (2007) 1121-1135
4. Dirksen M.T., Laarman G.J., Simoons M.L., and Duncker D.J. Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies. Cardiovasc Res 74 (2007) 343-355
5. Rochitte C.E., Lima J.A., Bluemke D.A., et al. Magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction. Circulation 98 (1998) 1006-1014
6. Atar D., Petzelbauer P., Schwitter J., et al. Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction: results of the F.I.R.E. (Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury) trial. J Am Coll Cardiol 53 (2009) 720-729
7. Wagner A., Mahrholdt H., Holly T.A., et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361 (2003) 374-379
8. Mahrholdt H., Wagner A., Holly T.A., et al. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging. Circulation 106 (2002) 2322-2327
9. Amado L.C., Gerber B.L., Gupta S.N., et al. Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model. J Am Coll Cardiol 44 (2004) 2383-2389
10. Schmidt A., Azevedo C.F., Cheng A., et al. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation 115 (2007) 2006-2014
11. Kramer C., Barkhausen J., Flamm S., et al. Standardized cardiovascular magnetic resonance imaging (CMR) protocols, Society for Cardiovascular Magnetic Resonance: Board of Trustees Task Force on Standardized Protocols. J Cardiovasc Magn Reson 10 (2008) 35
12. Abdel-Aty H., Zagrosek A., Schulz-Menger J., et al. Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 109 (2004) 2411-2416
13. Aletras A.H., Tilak G.S., Natanzon A., et al. Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (dense) functional validations. Circulation 113 (2006) 1865-1870
14. Friedrich M.G., Abdel-Aty H., Taylor A., et al. The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J Am Coll Cardiol 51 (2008) 1581-1587