Pathophysiology of the endothelin system - Lessons from genetically manipulated animal models

European Journal of Medical Research

Volumn 14, Issue 1, 2009, Pages 1-6

  von Websky, K ^a,b   Heiden, S ^a,b   Pfab, T ^a,b   Hocher, Berthold ^a  

^a DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; N(G) NITROARGININE METHYL ESTER; SODIUM; WATER;

ARTICLE; BRONCHIOLITIS; CARDIOVASCULAR SYSTEM; CONGESTIVE CARDIOMYOPATHY; CRANIOFACIAL MALFORMATION; DISEASE MODEL; DIURESIS; EMBRYO DEVELOPMENT; EPIDERMIS; GENE DISRUPTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC MANIPULATION; GLOMERULOSCLEROSIS; HEART DEVELOPMENT; HEART FUNCTION; HIRSCHSPRUNG DISEASE; INTESTINE INNERVATION; KIDNEY DEVELOPMENT; KIDNEY FIBROSIS; KIDNEY FUNCTION; KNOCKOUT MOUSE; LUNG FIBROSIS; MEDICAL RESEARCH; MELANOCYTE; NERVE CELL; NEURAL CREST; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKULL DEVELOPMENT; SKULL MALFORMATION; SODIUM EXCRETION; TISSUE REPAIR; TRANSGENIC ANIMAL;

EID: 59949098780     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: 10.1186/2047-783x-14-1-1     Document Type: Article

References (49)

1. Kedzierski RM, Yanagisawa M. Endothelin system: The double-edged sword in health and disease. Annual Review of Pharmacology and Toxicology 2001; 41:851-876.
2. Hocher B, ThoneReineke C, Rohmeiss P, Schmager F, Slowinski T, Burst V et al. Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. Journal of Clinical Investigation 1997; 99(6):1380-1389.
3. Shindo T, Kurihara H, Maemura K, Kurihara Y, Ueda O, Suzuki H et al. Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1. Journal of Molecular Medicine-Jmm 2002; 80(2): 105-116.
4. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y et al. A Novel Potent Vasoconstrictor Peptide Produced by Vascular Endothelial-Cells. Nature 1988; 332(6163):411-415.
5. Hocher B, ThoneReineke C, Bauer C, Raschack M, Neumayer HH. The paracrine endothetin system: Pathophysiology and implications in clinical medicine. European Journal of Clinical Chemistry and Clinical Biochemistry 1997; 35(3):175-189.
6. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annual Review of Physiology 1999; 61:391-415.
7. Rothermund L, Paul M. The role of endothelin in hypertension. Current Opinion in Nephrology and Hypertension 1998; 7(4):451-456.
8. Liefeldt L, Schonfelder G, Bocker W, Hocher B, Talsness CE, Rettig R et al. Transgenic rats expressing the human ET-2 gene: a model for the study of endothelin actions in vivo. Journal of Molecular Medicine-Jmm 1999; 77(7): 565-574.
9. Hocher B, Schwarz A, Slowinski T, Bachmann S, Pfeilschifter J, Neumayer HH et al. In-vivo interaction of nitric oxide and endothelin. J Hypertens 2004; 22(1):111-119.
10. Quaschning T, Voss F, Relle K, Kalk P, Vignon-Zellweger N, Pfab T et al. Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: Lessons from endothelin-1 transgenic/endothelial nitric oxide synthase knockout mice. Journal of the American Society of Nephrology 2007; 18(3):730-740.
11. Quaschning T, Voss F, Herzfeld S, Relle K, Kalk P, Godes M et al. Lack of iNOS Impairs Endothelial Function in Endothelin-1 Transgenic Mice. Kidney Blood Press Res 2008; 31(2):127-134.
12. Hocher B, Schwarz A, Fagan KA, Thone-Reineke C, El Hag K, Kusserow H et al. Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. American Journal of Respiratory Cell and Molecular Biology 2000: 23(1):19-26.
13. Amiri F, Virdis A, Neves ME, Iglarz M, Seidah NG, Touyz RM et al. Endothelium-restricted overexpression of human endothetin-1 causes vascular remodeling and endothelial dysfunction. Circulation 2004; 110(15):2233-2240.
14. Yang LL, Gros R, Kabir MG, Sadi A, Gotlieb AI, Husain M et al. Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice. Circulation 2004; 109(2):255-261.
15. Hocher B, Liefeldt L, Thone-Reineke C, Orzechowski HD, Distler A, Bauer C et al. Characterization of the renal phenotype of transgenic rats expressing the human endothelin-2 gene. Hypertension 1996; 28(2):196-201.
16. Baynash AG, Hosoda K, Giaid A, Richardson JA, Emoto N, Hammer RE et al. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 1994; 79(7):1277-1285.
17. Garcia RJ, Ittah A, Mirabal S, Figueroa J, Lopez L, Glick AB et al. Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. J Invest Dermatol 2008; 128(1):131-142.
18. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R et al. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 1994; 368(6473):703-710.
19. Kurihara Y, Kurihara H, Oda H, Maemura K, Nagai R, Ishikawa T et al. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 1995; 96(1):293-300.
20. Kurihara Y, Kurihara H, Maemura K, Kuwaki T, Kumada M, Yazaki Y. Impaired development of the thyroid and thymus in endothelin-1 knockout mice. J Cardiovasc Pharmacol 1995; 26 Suppl 3:S13-S16.
21. Slowinski T, Kalk P, Christian M, Schmager F, Relle K, Godes M et al. Cell-type specific interaction of endothelin and the nitric oxide system: pattern of prepro-ET-1 expression in kidneys of 1-NAME treated prepro-ET-1 promoter-lacZ-transgenic mice. Journal of Physiology-London 2007; 581(3):1173-1181.
22. Clouthier DE, Hosoda K, Richardson JA, Williams SC, Yanagisawa H, Kuwaki T et al. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 1998; 125(5):813-824.
23. Ling GY, Cao WH, Onodera M, Ju KH, Kurihara H, Kurihara Y et al. Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient mice. Brain Res 1998; 808(2):238-249.
24. Kuwaki T, Ling GY, Onodera M, Ishii T, Nakamura A, Ju KH et al. Endothelin in the central control of cardiovascular and respiratory functions. Clin Exp Pharmacol Physiol 1999; 26(12):989-994.
25. Morita H, Kurihara H, Kurihara Y, Shindo T, Kuwaki T, Kumada M et al. Systemic and renal response to salt loading in endothelin-1 knockout mice. J Cardiovasc Pharmacol 1998; 31 Suppl 1:S557-S560.
26. Kuwaki T, Cao WH, Kurihara Y, Kurihara H, Ling GY, Onodera M et al. Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1. Am J Physiol 1996; 270(6 Pt 2):R1279-R1286.
27. Ahn D, Ge Y, Stricklett PK, Gill P, Taylor D, Hughes AK et al. Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest 2004; 114(4):504-511.
28. Ge Y, Ahn D, Stricklett PK, Hughes AK, Yanagisawa M, Verbalis JG et al. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol 2005; 288(5):F912-F920.
29. Ge Y, Stricklett PK, Hughes AK, Yanagisawa M, Kohan DE. Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. Am J Physiol Renal Physiol 2005; 289(4):F692-F698.
30. Zhao XS, Pan W, Bekeredjian R, Shohet RV. Endogenous endothelin-1 is required for cardiomyocyte survival in vivo. Circulation 2006; 114(8):830-837.
31. Shohet RV, Kisanuki YY, Zhao XS, Siddiquee Z, Franco F, Yanagisawa M. Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci U S A 2004; 101(7):2088-2093.
32. Rice J, Doggett B, Sweetser DA, Yamagisawa H, Yanagisawa M, Kapur RP. Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice. Developmental Dynamics 2000; 217(1):120-132.
33. Kuwaki T, Ishii T, Ju K, Yanagisawa M, Fukuda Y. Blood pressure of endothelin-3 null (-/-) knockout mice and endothelin A receptor null (-/ -) knockout mice under anaesthesia. Clin Sci (Lond) 2002; 103 Suppl 48:48S-52S.
34. Hosoda K, Hammer RE, Richardson JA, Baynash AG, Cheung JC, Giaid A et al. Targeted and natural (piebaldlethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 1994; 79(7):1267-1276.
35. Gariepy CE, Williams SC, Richardson JA, Hammer RE, Yanagisawa M. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. J Clin Invest 1998; 102(6):1092-1101.
36. Gariepy CE, Ohuchi T, Williams SC, Richardson JA, Yanagisawa M. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. J Clin Invest 2000; 105(7):925-933.
37. Quaschning T, Rebhan B, Wunderlich C, Wanner C, Richter CM, Pfab T et al. Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading. J Hypertens 2005; 23(5):979-985.
38. Hocher B, Dembowski C, Slowinski T, Friese ST, Schwarz A, Siren AL et al. Impaired sodium excretion, decreased glomerular filtration rate and elevated blood pressure in endothelin receptor type B deficient rats. J Mol Med 2001; 78(11):633-641.
39. Pfab T, Thone-Reineke C, Theilig F, Lange I, Witt H, Maser-Gluth C et al. Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure. J Am Soc Nephrol 2006; 17(4):1082-1089.
40. Bagnall AJ, Kelland NF, Gulliver-Sloan F, Davenport AP, Gray GA, Yanagisawa M et al. Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt. Hypertension 2006; 48(2):286-293.
41. Ge Y, Bagnall A, Stricklett PK, Strait K, Webb DJ, Kotelevtsev Y et al. Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am J Physiol Renal Physiol 2006; 291(6): F1274-F1280.
42. Ohkita M, Wang Y, Nguyen ND, Tsai YH, Williams SC, Wiseman RC et al. Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats. Hypertension 2005; 45(5):940-946.
43. Emoto N, Yanagisawa M. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem 1995; 270(25):15262-15268.
44. Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D et al. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 1994; 78(3):473-485.
45. Yanagisawa H, Yanagisawa M, Kapur RP, Richardson JA, Williams SC, Clouthier DE et al. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development 1998; 125(5):825-836.
46. Yanagisawa H, Hammer RE, Richardson JA, Emoto N, Williams SC, Takeda S et al. Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest 2000; 105 (10):1373-1382.
47. Brand M, Kempf H, Paul M, Corvol P, Gasc JM. Expression of endothelins in human cardiogenesis. J Mol Med 2002; 80(11):715-723.
48. Puffenberger EG, Hosoda K, Washington SS, Nakao K, deWit D, Yanagisawa M et al. A Missense Mutation of the Endothelin-B Receptor Gene in Multigenic Hirschsprungs-Disease. Cell 1994; 79(7):1257-1266.
49. McCallion AS, Chakravarti A. EDNRB/EDN3 and Hirschsprung disease type II. Pigment Cell Res 2001; 14(3):161-169.