Second-trimester genetic sonogram for detection of fetal chromosomal abnormalities in a community-based antenatal testing unit

Ultrasound in Obstetrics and Gynecology

Volumn 33, Issue 2, 2009, Pages 161-168

  Bottalico, J N ^a,b   Chen, X ^a   Tartaglia, M ^a   Rosario, B ^a   Yarabothu, D ^a   Nelson, L ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b Department of Obstetrics and Gynecology ^*  (United States)

Author keywords

Chromosomal anomaly; Down syndrome; Genetic sonogram; Pregnancy; Ultrasonography

Indexed keywords

ARTICLE; BONE MALFORMATION; CHOROID PLEXUS TUMOR; CHROMOSOME ABERRATION; COMMUNITY CARE; COMMUNITY HOSPITAL; CONGENITAL MALFORMATION; DOWN SYNDROME; FEMUR MALFORMATION; FETUS; FETUS ECHOGRAPHY; HIGH RISK PREGNANCY; HUMAN; HUMERUS; MAJOR CLINICAL STUDY; PHALANX HYPOPLASIA; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; SECOND TRIMESTER PREGNANCY; SENSITIVITY AND SPECIFICITY; TRISOMY 13; TRISOMY 18;

CHROMOSOME DISORDERS; DOWN SYNDROME; FEMALE; HUMANS; PREGNANCY; PREGNANCY TRIMESTER, SECOND; PRENATAL CARE; RETROSPECTIVE STUDIES; ULTRASONOGRAPHY, PRENATAL;

EID: 59949090290     PISSN: 09607692     EISSN: 14690705     Source Type: Journal    
DOI: 10.1002/uog.6220     Document Type: Article

References (21)

1. Hobbins JC, Lezotte DC, Persutte WH, DeVore GR, Benacerraf BR, Nyberg DA, Vintzileos AM, Platt LD, Carlson DE, Bahado-Singh RO, Abuhamad AZ. An 8-center study to evaluate the utility of mid-term genetic sonograms among high-risk pregnancies. J Ultrasound Med 2003; 22: 33-38.
2. Schluter PJ, Pritchard G. Mid trimester sonographic findings for the prediction of Down syndrome in a sonographically screened population. Am J Obstet Gynecol 2005; 192: 10-16.
3. Malone F, Nyberg D, Vidaver J, Ball R, Comstock C, Saade G, Berkowitz R, Gross S, Dugoff L, Craigo S, Timor I, Carr S, Wolfe H, Canick J, Dalton M. First and second trimester evaluation of risk (FASTER) trial: The role of second trimester genetic sonography: 5. Am J Obstet Gynecol 2004; 191 (Suppl): S3.
4. Smith-Bindman R, Chu P, Goldberg J. Second trimester prenatal ultrasound for the detection of pregnancies at increased risk of Down syndrome. Prenat Diagn 2007; 27: 535-544.
5. Benn P, Egan JF. Second trimester prenatal ultrasound and screening for Down syndrome. Prenat Diagn 2007; 27: 884.
6. Smith-Bindman R, Hosmer W, Feldstein VA, Deeks JJ, Goldberg JD. Second-trimester ultrasound to detect fetuses with Down syndrome: a meta-analysis. JAMA 2001; 285: 1044-1055.
7. Bahado-Singh RO, Oz UA, Mendilcioglu I, Mahoney MJ. The mid-trimester genetic sonogram. Semin Perinatol 2005; 29: 209-214.
8. Wax JR, Guilbert J, Mather J, Chen C, Royer D, Steinfeld JD, Ingardia CJ. Efficacy of community-based second trimester genetic ultrasonography in detecting the chromosomally abnormal fetus. J Ultrasound Med 2000; 19: 689-694.
9. Benacerraf BR, Frigoletto FD, Jr. Soft tissue nuchal fold in the second-trimester fetus: standards for normal measurements compared with those in Down syndrome. Am J Obstet Gynecol 1987; 157: 1146-1149.
10. Benacerraf B. The significance of the nuchal fold in the second trimester fetus. Prenat Diagn 2002; 22: 798 -801.
11. Gray DL, Crane JP. Optimal nuchal skin-fold thresholds based on gestational age for prenatal detection of Down syndrome. Am J Obstet Gynecol 1994; 171: 1282-1286.
12. Benacerraf BR, Cnann A, Gelman R, Laboda LA, Frigoletto FD, Jr. Can sonographers reliably identify anatomic features associated with Down syndrome in fetuses? Radiology 1989; 173: 377-380.
13. Benacerraf BR, Neuberg D, Frigoletto FD, Jr. Humeral shortening in second-trimester fetuses with Down syndrome. Obstet Gynecol 1991; 77: 223-227.
14. th revision. American Medical Association Press: Chicago, 2003.
15. Wenstrom KD, Williamson RA, Grant SS. Detection of fetal Turner syndrome with multiple-marker screening. Am J Obstet Gynecol 1994; 170: 570-573.
16. Egan JF, Rodis JF, Benn PA. Ultrasound markers of fetal Down syndrome. JAMA 2001; 285: 2856-2857; Author reply: 2858.
17. Vintzileos AM, Egan JF. Adjusting the risk for trisomy 21 on the basis of second-trimester ultrasonography. Am J Obstet Gynecol 1995; 172: 837-844.
18. Egan JF, Benn P, Borgida AF, Rodis JF, Campbell WA, Vintzileos AM. Efficacy of screening for fetal Down syndrome in the United States from 1974 to 1997. Obstet Gynecol 2000; 96: 979-985.
19. Bromley B, Lieberman R, Benacerraf BR. Choroid plexus cysts: not associated with Down syndrome. Ultrasound Obstet Gynecol 1996; 8: 232-235.
20. Shipp TD, Benacerraf BR. Second trimester ultrasound screening for chromosomal abnormalities. Prenat Diagn 2002; 22: 296-307.
21. Egan JF. The genetic sonogram in second trimester down syndrome screening. Clin Obstet Gynecol 2003; 46: 897-908.