Characterization of the V1a antagonist, JNJ-17308616, in rodent models of anxiety-like behavior

Psychopharmacology

Volumn 202, Issue 4, 2009, Pages 711-718

  Bleickardt, C J ^a   Mullins, D E ^a   MacSweeney, C P ^a   Werner, B J ^a   Pond, A J ^a   Guzzi, M F ^a   Martin, F D C ^a   Varty, G B ^a   Hodgson, R A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anxiety; AVP; In vivo; Mouse; Rat; V1a receptor; Vasopressin

Indexed keywords

ANXIOLYTIC AGENT; JNJ 17308616; OXYTOCIN RECEPTOR; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN V1A RECEPTOR; VASOPRESSIN V1B RECEPTOR; VASOPRESSIN V2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EXPERIMENTAL MODEL; FEMALE; HUMAN; LICKING; LOCOMOTION; MALE; MAZE TEST; MOOD DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR AFFINITY; RECOGNITION; SCRATCHING; VOCALIZATION;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; ARGININE VASOPRESSIN; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASOPRESSIN; RECOGNITION (PSYCHOLOGY); SOCIAL BEHAVIOR; SPIRO COMPOUNDS; VASOPRESSINS; VOCALIZATION, ANIMAL;

EID: 59849111655     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1354-x     Document Type: Article

References (20)

1. IF Bielsky SB Hu KL Szegda H Westphal LJ Young 2004 Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice Neuropsychopharmacology 29 483 493
2. N Egashira A Tanoue F Higashihara K Mishima Y Fukue Y Takano G Tsujimoto K Iwasaki M Fujiwara 2004 V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze Neurosci Lett 356 195 198
3. N Egashira A Tanoue T Matsuda E Koushi S Harada Y Tanako G Tsujimoto K Mishima K Iwasaki M Fujiwara 2007 Impaired social interaction and reduced anxiety-like behavior in vasopressin V1a receptor knockout mice Behav Brain Res 178 123 127
4. HG Everts JM Koolhaas 1999 Differential modulation of lateral septal vasopressin receptor blockade in spatial learning, social recognition, and anxiety-related behaviors in rats Behav Brain Res 99 7 16
5. G Griebel J Simiand C Serradeil-Le Gal J Wagnon M Pascal B Scatton JP Maffrand P Soubrie 2002 Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders Proc Natl Acad Sci U S A 99 6370 6375
6. G Griebel J Simiand J Stemmelin CS Gal R Steinberg 2003 The vasopressin V1b receptor as a therapeutic target in stress-related disorders Curr Drug Targets CNS Neurol Disord 2 191 200
7. Gunnet JW, Look R, Vaidya AH, Xiang M, Chen RH, Combs DW, Demarest KT. The characterization of JNJ-17308616: a potent and selective vasopressin-1A (V1a) receptor antagonist. Program No 115.1. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online
8. Hodgson RA, Guthrie DG, Pond AJ, Morgan C, Lu X, Mullins D, Miller M, Stamford A, Guzzi M, Parker EM, Varty GB. Characterization of a novel nonselective V1a/b antagonist (SCH 756491) in animal models of anxiety-like behavior. Program No. 828.6 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online
9. RA Hodgson GA Higgins DH Guthrie SX Lu AJ Pond DE Mullins MF Guzzi EM Parker GB Varty 2007 Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression Pharmacol Biochem Behav 86 431 440
10. M Iijima S Chaki 2007 An arginine vasopressin V1b antagonist, SSR149415 elicits antidepressant-like effects in an olfactory bulbectomy model Prog Neuropsychopharmacol Biol Psychiatry 31 622 627
11. CD Kilts R Commissaris RH Rech 1981 Comparison of anti-conflict drug effects in three experimental animal models of anxiety Psychopharmacology (Berl) 74 290 296
12. G Liebsch CT Wotjak R Landgraf M Engelmann 1996 Septal vasopressin modulates anxiety-related behaviour in rats Neurosci Lett 217 101 104
13. Lu SX, Carey GJ, Varty GB Nociceptin produces anxiolytic-like effects in a rat conditioned lick suppression model. Program No. 683.1. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online
14. LA Lumley CL Robison WK Chen B Mark JL Meyerhoff 2001 Vasopressin into the preoptic area increases grooming behavior in mice Physiol Behav 73 451 455
15. G Meisenberg 1988 Vasopressin-induced grooming and scratching behavior in mice Ann N Y Acad Sci 525 257 269
16. C Murgatroyd A Wigger E Frank N Singewald M Bunck F Holsboer R Landgraf D Spengler 2004 Impaired repression at a vasopressin promoter polymorphism underlies over expression of vasopressin in a rat model of trait anxiety J Neurosci 24 7762 7770
17. K Njung'e SL Handley 1991 Evaluation of marble-burying behavior as a model of anxiety Pharmacol Biochem Behav 38 63 67
18. C Serradeil-Le Gal J Wagnon B Tonnerre R Roux G Garcia G Griebel A Aulombard 2005 An overview of SSR149415, a selective nonpeptide vasopressin V(1b) receptor antagonist for the treatment of stress-related disorders CNS Drug Rev 11 53 68
19. Vaidya AH, Rosenthal D, Milewski M, Dubinsky B, Demarest KT, Chen RH, Combs DW, Reitz AB, Gunnet JW, Plata-Salaman CR. JNJ-17308616: A vasopressin-1A (V1A) receptor antagonist for the treatment of anxiety. Program No 115.2. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online
20. SR Wersinger HK Caldwell L Martinez P Gold SB Hu WS Young 3rd 2007 Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression Genes Brain Behav 6 540 551