Editorial: Sex hormones save our skin: The vascular networking of estrogen

Circulation Research

Volumn 104, Issue 2, 2009, Pages 135-137

  Werner, Nikos ^a   Nickenig, Georg ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Estrogens; Skin necrosis; Vascular biology

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; PROTEIN BCL 2; SEX HORMONE; TRANSFORMING GROWTH FACTOR BETA; ESTRADIOL;

ANGIOGENESIS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; EDITORIAL; ENDOTHELIUM CELL; ESTROGEN THERAPY; ISCHEMIA; NONHUMAN; OVARIECTOMY; PARABIOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; SKIN BLOOD VESSEL; SKIN FLAP; SKIN NECROSIS; ANIMAL; BLOOD FLOW; DISEASE MODEL; DRUG IMPLANT; FEMALE; HUMAN; METABOLISM; NECROSIS; NOTE; PATHOLOGY; PATHOPHYSIOLOGY; PLASTIC SURGERY; VASCULARIZATION; WOMEN'S HEALTH;

ANIMALS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DRUG IMPLANTS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; ISCHEMIA; NECROSIS; OVARIECTOMY; REGIONAL BLOOD FLOW; SKIN; SURGICAL FLAPS; WOMEN'S HEALTH;

EID: 59849097650     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.192534     Document Type: Editorial

References (18)

1. Farquhar CM, Marjoribanks J, Lethaby A, Lamberts Q, Suckling JA. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 2005;CD004143.
2. Rosano GM, Vitale C, Silvestri A, Fini M. Hormone replacement therapy and cardioprotection: the end of the tale? Ann N Y Acad Sci. 2003;997: 351-357.
3. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmeno-pausal hormone replacement therapy: scientific review. JAMA. 2002;288: 872-881.
4. Hu FB, Grodstein F. Postmenopausal hormone therapy and the risk of cardiovascular disease: the epidemiologic evidence. Am J Cardiol. 2002; 90:26F-29F.
5. Miller VM, Duckles SP. Vascular actions of estrogens: functional implications. Pharmacol Rev. 2008;60:210-241.
6. Stirone C, Boroujerdi A, Duckles SP, Krause DN. Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects. Mol Pharmacol. 2005;67:105-113.
7. Strehlow K, Rotter S, Wassmann S, Adam O, Grohe C, Laufs K, Bohm M, Nickenig G. Modulation of antioxidant enzyme expression and function by estrogen. Circ Res. 2003;93:170-177.
8. Fontaine V, Filipe C, Werner N, Gourdy P, Billon A, Garmy-Susini B, Brouchet L, Bayard F, Prats H, Doetschman T, Nickenig G, Arnal JF. Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization. Am J Pathol. 2006;169:1855-1862.
9. Strehlow K, Werner N, Berweiler J, Link A, Dirnagl U, Priller J, Laufs K, Ghaeni L, Milosevic M, Bohm M, Nickenig G. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation. 2003;107:3059-3065.
10. Iwakura A, Luedemann C, Shastry S, Hanley A, Kearney M, Aikawa R, Isner JM, Asahara T, Losordo DW. Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothe-lial progenitor cells contributes to reendothelialization after arterial injury. Circulation. 2003;108:3115-3121.
11. Krasinski K, Spyridopoulos I, Asahara T, van der ZR, Isner JM, Losordo DW. Estradiol accelerates functional endothelial recovery after arterial injury. Circulation. 1997;95:1768-1772.
12. Spyridopoulos I, Sullivan AB, Kearney M, Isner JM, Losordo DW. Estrogen-receptor-mediated inhibition of human endothelial cell apopto-sis. Estradiol as a survival factor. Circulation. 1997;95:1505-1514.
13. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002; 288:321-333.
14. Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix AZ, Margolis KL, Stefanick ML. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA. 2007;297:1465-1477.
15. Toutain CE, Brouchet L, Raymond-Letron I, Vicendo P, Fouque MJ, Bergès H, Krust A, Chambon P, Gourdy P, Arnal JF, Lenfant F. Prevention of skin flap necrosis by estradiol involves reperfusion of a protected vascular network. Circ Res. 2009;104:245-254.
16. Aicher A, Rentsch M, Sasaki K, Ellwart JW, Fandrich F, Siebert R, Cooke JP, Dimmeler S, Heeschen C. Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ Res. 2007;100:581-589.
17. Heil M, Schaper W. Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ Res. 2004;95: 449-458.
18. Friedrich EB, Clever YP, Wassmann S, Hess C, Nickenig G. 17Beta-estradiol inhibits monocyte adhesion via down-regulation of Rac1 GTPase. J Mol Cell Cardiol. 2006;40:87-95.