Opposite effects of angiotensin II and angiotensin (1-7) on impulse propagation, excitability and cardiac arrhythmias. Is the overexpression of ACE2 arrhythmogenic?

Regulatory Peptides

Volumn 153, Issue 1-3, 2009, Pages 7-10

  De Mello, Walmor C ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

ACE; ACE2; Angiotensin (1 7); Angiotensin II; Cardiac arrhythmias

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN[1-7]; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL;

ARRHYTHMOGENESIS; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART MUSCLE EXCITABILITY; HEART VENTRICLE REMODELING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ACTION POTENTIALS; ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; ARRHYTHMIAS, CARDIAC; HUMANS; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; SIGNAL TRANSDUCTION;

EID: 59849093598     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2007.12.006     Document Type: Review

References (36)

1. De Mello W.C., and Danser A.H.J. Angiotensin II and the heart. On the intracrine renin angiotensin system. Hypertension 35 (2000) 1183-1188
2. De Mello W.C. Renin angiotensin system and cell communication in the failing heart. Hypertension 27 (1996) 1267-1272
3. De Mello W.C. Cell coupling and impulse propagation in the failing heart. J Cardiovasc Electrophysiol 10 (1999) 1409-1430
4. Robert V., Silvestre J.S., Charlemagne D., Sabri A., Trouve P., Wassef M., et al. Biological determinants of aldosterone-induced cardiac fibrosis in rat. Hypertension 26 (1995) 971-978
5. Asano K., Dutcher D., Port J., Minobe W.A., Tremmel K.D., Roden R.L., Bohlmeyer T.J., et al. Selective downregulation of the angiotensin II AT1-receptor subtype in the failing human ventricular myocardium. Circulation 95 (1997) 1193-1200
6. Studer R., Reinecke H., Muller B., et al. Increased angiotensin I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction. J Clin Invest 94 (1994) 301-310
7. Oudit G.Y., Kassiri Z., Patel M.P., Chappell M., Butany J., Backx P.H., Tsuchima R.G., Scholey J.W., Khokha R., and Penniger J.M. Angiotensin II-mediated oxidative stress and inflammation mediated the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res 75 (2007) 29-39
8. Waeber B. Combination therapy with ACE inhibitors/angiotensin II receptor antagonists and diuretics in hypertension. Expert Rev Cardiovasc 1 (2002) 43-50
9. De Mello W.C., and Specht P. Chronic blockade of angiotensin II AT1 receptors increased cell-to-cell communication, reduces fibrosis and improved impulse propagation in the failing heart. J Renin Angiotensin Aldosterone Syst 7 (2006) 201-205
10. Rudy Y., and Quan W.R. A model study of the effects of discrete cellular structure on electrical propagation in cardiac muscle. Circ Res 61 (1987) 815-823
11. Shaw R., and Rudy Y. Gap junctions and the spread of electrical excitation. In: De Mello W.C., and Janse M. (Eds). Heart cell communication in health and disease (1998), Kluwer Academic Publishers, Boston 125-147
12. Harada K., Komuro I., Haayashi D., Sugaya T., Murakami K., and Tzaki Y. Angiotensin II, type 1a receptor is involved in the occurrence of reperfusion arrhythmias. Circulation 97 (1998) 315-317
13. Kumagai K., Nakashima H., Urata H., Gondo N., Arakawa K., and Saku K. Effects of an angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation. J Am Coll Cardiol 41 (2003) 2197-2204
14. Ehrlich J.R., Hohnloser S.H., and Nattel S. Role of angiotensin system and effects of its inhibition in atrial fibrillation; clinical and experimental evidence. Eur Heart J 27 (2006) 512-518
15. Severs N.J., Coppen S.R., Dupont E., Yeh H.I., Ko Y.S., and Matsushita T. Gap junction alteration in human heart disease. Cardiovasc Res 62 (2004) 368-377
16. Kaab S., Nun H.B., Chiamvimonvat N., O'Rourke B., Pak P.H., Kass D.A., Marban E., and Tomaselli G.F. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78 (1996) 262-273
17. O'Rourke B., Kass D.A., Tomaselli G.F., Kaab S., Tunin R., and Marban E. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. Circ Res 84 (1999) 562-570
18. Akar F.G., and Rosenbaum D.S. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ Res 93 (2003) 638-645
19. Antzelevitch C. Cardiac repolarization. The long and the short of it. Europace 7 (2005) S3-S9
20. De Mello W.C. Heart failure: how important is cellular sequestration? The role of the renin angiotensin-aldosterone system. J Mol Cell Cardiol 37 (2004) 431-438
21. Patlolla V., Alsheikh-Ali A.A., and Al-Ahmad A.M. The renin angiotensin system: a therapeutic target in atrial fibrillation. Pacing Clin Electrophysiol 29 (2006) 1006-1012
22. De Mello W.C., and Monterrubio J. Intracellular and extracellular angiotensin II enhance L-type calcium current in the failing heart. Hypertension 44 (2004) 360-364
23. De Mello W.C. Cardiac arrhythmias; the possible role of the renin angiotensin system. J Mol Med 79 (2001) 103-108
24. Donoghue M., Hsieh F., Baronas E., et al. A novel angiotensin converting enzyme related carboxypeptidase (ACE2) converts angiotensin 1 to angiotensin (1-9). Circ Res 87 (2000) E1-E9
25. Abbas A.G., Grelik L., and Carbiini S.A. Angiotensin (1-7) induces bradykinin-mediated hypotensive responses in anesthetized rats. Hypertension 30 (1997) 217-221
26. Crackower M.A., Sarao R., Oudit G.Y., Yagil C., Kozierdzki I., Scanga S.E., et al. Angiotensin converting enzyme 2 is an essential regulator of heart function. Nature 417 (2002) 822-828
27. Zisman L.S., Keller R.S., Weaver B., et al. Increased angiotensin (1-7) forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin converting enzyme homolog, ACE2. Circulation 108 (2003) 1707-1712
28. Goulter A.B., Goddard M.J., Allen J.C., and Clark K.L. ACE2 gene is upregulated in the human failing heart. BMC Med 19 (2004) 19
29. Ferrario C.M., Chappell M.C., Tallant E.A., Brosnihan K.B., and Diz D.I. Counterregulatory actions of angiotensin (1-7). Hypertension 30 (1997) 535-541
30. Santos R.A., Simoes e Silva A.C., Maric C., Silva D.M., Machado R.P., de Buhr I., Heringer-Walther S., et al. Angiotensin (1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA 100 (2003) 8258-8263
31. Ferreira A.J., Santos R.A., and Almeida A.P. Angiotensin (1-7): cardioprotective effect in myocardial ischemia/reperfusion. Hypertension 38 (2001) 665-668
32. De Mello W.C. Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischemia-reperfusion. The role of the sodium pump. J Renin Angiotensin Aldosterone Syst 5 (2004) 203-208
33. De Mello W.C., Ferrario C., and Jessup J.A. Beneficial versus harmful effects of angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst 8 (2007) 74-80
34. Oudit G.Y., Crakower M.A., Backx P.H., and Penninger J.M. The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med 13 (2003) 93-101
35. Grobe J.L., Mecca A.P., Lingis M., Shenoy V., Bolton T.A., Machado J.M., Speth R.C., Raizada M.K., and Katovich M.J. Prevention of angiotensin II-induced cardiac remodeling by angiotensin (1-7). Am J Physiol Heart Circ Physiol 292 (2007) H736-H742
36. Donahue M., Wakimoto H., Maguire C.T., Acton S., Hales P., Stagliano N., et al. Heart block, ventricular tachycardia and sudden death in ACE2 transgenic mice with down regulated connexins. J Mol Cell Cardiol 35 (2003) 1043-1053