Isolation and study of antibiotic INA-1132 (chlorothricin), produced by actinomycete strain

Antibiotiki i Khimioterapiya

Volumn 53, Issue 7-8, 2008, Pages 3-7

  Terekhova, L P ^a   Galatenko, O A ^a   Trenin, A S ^a   Tolstykh, I V ^a   Zenkova, V A ^a   Zhukhlistova, N E ^b   Olkhovatova, O L ^a   Malkina, N D ^a   Boikova, Y U V ^a   Ustinova, E V ^a   Katrukha, G S ^a  

^a GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^b SHUBNIKOV INSTITUTE OF CRYSTALLOGRAPHY   (Russian Federation)

Author keywords

Antibiotic ina 1132; Chlorothricin; Halobacterium salinarum (halobacterium halobium); Hypolipidemic activity; Streptomyces baanensis; X ray analysis

Indexed keywords

AMINOGLYCOSIDE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTILIPEMIC AGENT; CHLOROTHRICIN; STEROL;

ACTINOBACTERIA; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; DRUG EFFECT; GRAM POSITIVE BACTERIUM; HALOBACTERIUM SALINARUM; METABOLISM; STREPTOMYCES; X RAY CRYSTALLOGRAPHY;

ACTINOBACTERIA; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTILIPEMIC AGENTS; CRYSTALLOGRAPHY, X-RAY; GRAM-POSITIVE BACTERIA; HALOBACTERIUM SALINARUM; MOLECULAR CONFORMATION; STEROLS; STREPTOMYCES;

ACTINOBACTERIA; BACTERIA (MICROORGANISMS); FUNGI; HALOBACTERIUM SALINARUM; STREPTOMYCES;

EID: 59849089429     PISSN: 02352990     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Shirting E. B., Gottlieb D. Methods for characterization of Streptomyces species. Int J Syst Bacteriol 1966; 16: 313-340.
2. Tay3e Streptomyces, Streptoverticillium, Chainia M.: 1983, 258.
3. Lechevalier M. P. Identification of aerobic actinomycetes of clinical importance. J Lab Clin Med, 1968; 71: 934-944.
4. Staneck G. L., Roberts L. D. Simplified approach to identification of aerobic actinomycetes by thin-layer chromatography. Appl Microbiol 1974;28:226-221.
5. Hasegawa T., Takisawa M., Tanida S. A rapid analysis for chemical grouping of aerobic actinomycetes. J Gen Appl Microbiol 1983; 29: 319-322.
6. Fitch M. E., Mangels A. R., Altmann W. A. et al. Microbiological screening of mevalonate suppressive minor plant constituents. J Agric Food Chem 1989, 37:687-691.
7. Russian source
8. Endo A., Monacolin K. A new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryI coenzyme A reductase. J Antibiot (Tokyo) 1980; 33: 334-336.
9. Russian source
10. Sheldrick G. M. SHELX97. Program for the Solution and Refinement of Crystal Structures. University of Göttingen, Germany, 1997.
11. Berdy J. BNPD, data base for microbial metabolite research. Abstr of Intern Conf Microbial Secondary Metabolism. Interlaken, Suisse 1994:2.
12. Keller-Schierlein W., Muntwikr R., Pache W., Zähner H. Stoffwechselprodukte von Mikroorganismen. Chlorothricin und Deschlorothricin. Helv Chim Acta 1969; 52: 127-142.
13. Muntwikr R., Keller-Schierlein W. Stoffwechselprodukte von Mikroorganismen. Die Struktur des chlorothricins, eines neuartigen Macrolid-Antibioticums. Helv Chim Acta 1972; 55: 2094-2102.
14. Cabrera J. A., Bolds J., Shields R. E. et al. Isoprenoid synthesis in Halobacterium halobium. Modulation of 3-hydroxy-3-methylglutaryl coenzyme a concentration in response to mevalonate availability. J Biol Chem 1986; 261: 3578-3583.
15. Kawashima A., Nakamura Y., Ohta Y. et al. New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethyl-hydroxychlorothricin), -033 and-034. J Antibiot 1992; 45: 207-212.