Liposome dependent delivery of S-adenosyl methionine to cells by liposomes: A potential treatment for liver disease

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 573-582

  Wagner, Eric J ^a   Krugner Higby, Lisa ^a   Heath, Timothy D ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Drug targeting; Encapsulation; Formulation; Liposomes; Site specific delivery; Targeted drug delivery

Indexed keywords

CHOLESTEROL; DISTEAROYLPHOSPHATIDYLCHOLINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FORMALDEHYDE; FORMIC ACID; GLUTATHIONE; HOMOCYSTEINE; INTERLEUKIN 6; LIPOSOME; METHANOL; S ADENOSYLMETHIONINE; 1,4 BUTANEDISULFONATE; 1,4-BUTANEDISULFONATE; ALKANESULFONIC ACID; CHELATING AGENT; DISTEAROYL PHOSPHATIDYLGLYCEROL; EDETIC ACID; PHOSPHATIDYLGLYCEROL; PROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG POTENCY; DRUG TARGETING; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH INHIBITION; LIVER DISEASE; LIVER FAILURE; MAMMAL CELL; NONHUMAN; ANIMAL; CELL PROLIFERATION; CERCOPITHECUS; CHEMISTRY; CHO CELL; CRICETULUS; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFECT; DRUG STABILITY; HAMSTER; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; PH;

ALKANESULFONATES; ANIMALS; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; CHELATING AGENTS; CHEMISTRY, PHARMACEUTICAL; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; DRUG STABILITY; EDETIC ACID; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-6; LIPOSOMES; LIVER FAILURE; MACROPHAGES; MICE; PHOSPHATIDYLGLYCEROLS; PROTECTIVE AGENTS; S-ADENOSYLMETHIONINE;

EID: 59849088545     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21460     Document Type: Article

References (35)

1. Hanto DW, Fishbein TM, Pinson CW, Olthoff KM, Shiffman ML, Punch JD, Goodrich NP. 2005. Liver and intestine transplantation: Summary analysis, 1994-2003. Am J Transpl 5:916-933.
2. Action plan for liver disease research: A report of the Liver Disease Subcommittee of the Digestive Diseases Interagency Coordinating Committee. 2004. National Institutes of Health, Washington D.C.
3. Hoofnagle JH, Kresina T, Fuller RK, Lake JR, Lucey MR, Sorrell MF, Beresford TP. 1997. Liver transplantation for alcoholic liver disease: Executive statement and recommendations. Summary of a National Institutes of Health workshop held December 6-7, 1996, Bethesda, Maryland. Liver Transpl Surg 3:347-350.
4. Lu SC, Alvarez L, Huang ZZ, Chen LX, An W, Corrales FJ, Avila MA, Kanel G, Mato JM. 2001. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 98:5560-5565.
5. Lieber CS, Packer L. 2002. S-adenosylmethionine: Molecular, biological, and clinical aspects - An introduction. Am J Clin Nutr 76:1148S-1150S.
6. Chen L, Zeng Y, Yang H, Lee TD, French SW, Corrales FJ, Garcia-Trevijano ER, Avila MA, Mato JM, Lu SC. 2004. Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. FASEB J 18:914-916.
7. Litovitz TL, Klein-Schwartz W, White S, Cobaugh DJ, Youniss J, Omslaer JC, Drab A, Benson BE. 2001. 2000 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 19:337-395.
8. Bartlett D. 2004. Acetaminophen toxicity. J Emerg Nurs 30:281-283.
9. Lee TD, Sadda MR, Mendler MH, Bottiglieri T, Kanel G, Mato JM, Lu SC. 2004. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 28:173-181.
10. Lu SC. 2000. S-Adenosylmethionine. Int J Biochem Cell Biol 32:391-395.
11. Friedel HA, Goa KL, Benfield P. 1989. S-Adenosyl-L-Methionine - A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs 38:389-416.
12. Mato JMCJ, de Paz JF, Caballeria L, Coll S, Caballero A, Garcia-Buey L, Beltran J, Benita V, Caballeria J, Sola R, Moreno-Otero R, Barrao F, Martin-Duce A, Correa JA, Pares A, Barrao E, Garcia-Magaz I, Puerta JL, Moreno J, Boissard G, Ortiz P, Rodes J. 1999. S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicenter clinical trial. Hepatology 30:1081-1089.
13. Song ZY, Chen T, Deaciuc IV, Uriarte S, Hill D, Barve S, McClain CJ. 2004a. Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe). Cytokine 28:214-223.
14. Wallace KP, Center SA, Hickford FH, Warner KL, Smith S. 2002. S-adenosyl-L-methionine (SAMe) for the treatment of acetaminophen toxicity in a dog. J Am Anim Hosp Assoc 38:246-254.
15. Song ZY, Uriarte S, Sahoo R, Chen T, Barve S, Hill D, McClain C. 2005. S-adenosylmethionine (SAMe) modulates interleukin-10 and interleukin-6, but not TNF, production via the adenosine (A2) receptor. Biochim Biophys Acta Mol Cell Res 1743:205-213.
16. Curran RD, Billiar TR, Stuehr DJ, Ochoa JB, Harbrecht BG, Flint SG, Simmons RL. 1990. Multiple cytokines are required to induce hepatocyte nitric-oxide production and inhibit total protein-synthesis. Ann Surg 212:462-471.
17. Su GL. 2002. Lipopolysaccharides in liver injury: Molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 283:G256-G265.
18. Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. 1997. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26:1530-1537.
19. Watson WH, Zhao YM, Chawla RK. 1999. S-adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor alpha. Biochem J 342:21-25.
20. Galun E, Axelrod JH. 2002. The role of cytokines in liver failure and regeneration: Potential new molecular therapies. Biochim Biophys Acta Mol Cell Res 1592:345-358.
21. McMillan JM, Walle UK, Walle T. 2005. S-adenosyl-L-methionine: Transcellular transport and uptake by Caco-2 cells and hepatocytes. J Pharm Pharmacol 57:599-605.
22. Chishty M, Reichel A, Abbott NJ, Begley DJ. 2002. S-adenosylmethionine is substrate for carrier mediated transport at the blood-brain barrier in vitro. Brain Res 942:46-50.
23. Heath TD, Lopez NG, Papahadjopoulos D. 1985. The effects of liposome size and surface-charge on liposome-mediated delivery of methotrexate-gamma- aspartate to cells-in vitro. Biochim Biophys Acta 820:74-84.
24. Heath TD, Lopez NG, Piper JR, Montgomery JA, Stern WH, Papahadjopoulos D. 1986. Liposome-mediated delivery of pteridine antifolates to cells-in vitro - Potency of methotrexate, and its alpha-substituents and gamma-substituents. Biochim Biophys Acta 862:72-80.
25. Heath TD, Brown CS. 1989. Liposome dependent delivery of N-(phosphonacetyl)-L-aspartic acid to cells in vitro. J Liposome Res 1:303-317.
26. Heath TD, Brown CS, Chan JC. 1999. Anionic liposomes deliver different liposome dependent drugs to cells with variable efficiency: An explanation based on the optimal timing of drug delivery. J Liposome Res 9:81-93.
27. Amin K, Ng KY, Brown CS, Bruno MS, Heath TD. 2001. LDL induced association of anionic liposomes with cells and delivery of contents as shown by the increase in potency of liposome dependent drugs. Pharm Res 18:914-921.
28. Mertz JE, Berg P. 1974. Defective simian virus 40 genomes: Isolation and growth of individual clones. Virology 62:121-124.
29. Raschke WC, Baird S, Ralph P, Nakoinz I. 1978. Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 15:261-267.
30. Krieger M, Brown MS, Goldstein JL. 1981. Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein. J Mol Biol 150:167.
31. Szoka FC, Papahadjopoulos D. 1978. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci USA 75:4194-4198.
32. Bartlett GR. 1959. Phosphorous assay in column chromatography. J Biol Chem 234:466-468.
33. Goren JL, Stoll AL, Damico KE, Sarmiento IA, Cohen BM. 2004. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 24:1501-1507.
34. Guerri C, Godfrey W, Grisolia S. 1976. Protection against toxic effects of formaldehyde in vitro, and of methanol or formaldehyde in vivo, by subsequent administration of SH reagents. Physiol Chem Phys 8:543-550.
35. Juliano RL, Stamp D. 1975. Effect of particle-size and charge on clearance rates of liposomes and liposome encapsulated drugs. Biochem Biophys Res Commun 63:651-658.