Genotypic versus phenotypic characterization, with respect to β-lactam susceptibility, of Haemophilus influenzae isolates exhibiting decreased susceptibility to β-lactam resistance markers

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 1, 2009, Pages 267-270

  Sevillano, David ^a   Giménez, María José ^a   Cercenado, Emilia ^b   Cafini, Fabio ^a   Gené, Amadeo ^c   Alou, Luis ^a   Marco, Francesc ^d   Martínez Martínez, Luis ^e   Coronel, Pilar ^f   Aguilar, Lorenzo ^a  

^a SCHOOL OF MEDICINE   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c Section of Gastroenterology   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^f Tedec Meiji Farma SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; BACTERIAL PROTEIN; BETA LACTAMASE; CEFACLOR; CEFDINIR; CEFUROXIME; CEPHALOSPORIN; PROTEIN FTSI; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; GENE MUTATION; GENOTYPE; HAEMOPHILUS INFECTION; HAEMOPHILUS INFLUENZAE; HUMAN; MINIMUM INHIBITORY CONCENTRATION; PEDIATRIC HOSPITAL; PHENOTYPE; PRIORITY JOURNAL; VIRUS ISOLATION;

BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; GENOTYPE; HAEMOPHILUS INFLUENZAE; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; PHENOTYPE;

EID: 59749105223     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00402-08     Document Type: Article

References (9)

1. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed. Approved standard. CLSI document M7-A7. Clinical Laboratory Standards Institute, Wayne, PA.
2. Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial susceptibility testing; 18th informational supplement. CLSI document M100-S18. Clinical and Laboratory Standards Institute, Wayne, PA.
3. Dabernat, H., C. Delmas, M. Seguy, R. Pelissier, G. Faucon, S. Bennamani, and C. Pasquier. 2002. Diversity of beta-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae. Antimicrob. Agents Chemother. 46:2208-2218.
4. García-Cobos, S., J. Campos, E. Lázaro, F. Román, E. Cercenado, C. García-Rey, M. Pérez-Vázquez, J. Oteo, and F. de Abajo. 2007. Ampicillin-resistant non-beta-lactamase-producing Haemophilus influenzae in Spain: recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. Antimicrob. Agents Chemother. 51:2564-2573.
5. García-de-Lomas, J., M. Lerma, L. Cebrián, J. L. Juan-Bañón, P. Coronel, M. J. Giménez, and L. Aguilar. 2007. Influence of Haemophilus influenzae beta-lactamase production and/or ftsI gene mutations on in vitro activity of and susceptibility rates to aminopenicillins and second- and third-generation cephalosporins. Int. J. Antimicrob. Agents 30:190-192.
6. Kaczmarek, F. S., T. D. Gootz, F. Dib-Hajj, W. Shang, S. Hallowell, and M. Cronan. 2004. Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin. Antimicrob. Agents Chemother. 48:1630-1639.
7. O'Callaghan, C. H., S. M. Kirby, A. Morris, R. E. Waller, and R. E. Duncombe. 1972. Correlation between hydrolysis of the β-lactam bond of the cephalosporin nucleus and expulsion of the 3-substituent. J. Bacteriol. 110:988-991.
8. Scriver, S. R., S. L. Walmsley, C. L. Kau, D. J. Hoban, J. Brunton, A. McGeer, T. C. Moore, E. Witwicki, et al. 1994. Determination of antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae and characterization of their beta-lactamases. Antimicrob. Agents Chemother. 38:1678-1680.
9. Ubukata, K., Y. Shibasaki, K. Yamamoto, N. Chiba, K. Hasegawa, Y. Takeuchi, K. Sunakawa, M. Inoue, and M. Konno. 2001. Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob. Agents Chemother. 45:1693-1699.