The role of RDW, erythrocyte morphology and platelet parameters in the differentiation between microcytic and hypochromic anemias;O papel do RDW, da morfologia eritrocitária e de parâmetros plaquetários na diferenciação entre anemias microcíticas e hipocrômicas

Revista Brasileira de Hematologia e Hemoterapia

Volumn 30, Issue 6, 2008, Pages 463-469

  Matos, Januária F ^a,b   Carvalho, Maria Das Graças ^b,e   Dusse, Luci M S ^b   Ferreira, Mônica De F R ^b,c,d   Stubbert, Rachel V B ^b,d  

^a Hematologia Clinica/Funcesi (Fundacao Comunitaria de Ensino Superior de Itabira)   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c Hematologia Clínica Instituto Newton Paiva

^d Hospital Governador Israel Pinheiro (Ipsemg)   (Brazil)

^e Departamento de Análises Clínicas e Toxicológicas ^*  (Brazil)

Author keywords

Erythrocyte morphology; Microcytic and hypochromic anemias; Platelet parameters; Red cell distribution width

Indexed keywords

EID: 59749086275     PISSN: 15168484     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Oliveira RAG, Neto AP. Anemias e Leucemias - Conceitos Básicos e Diagnóstico por técnicas laboratoriais. São Paulo: Roca, 2004. 421p.
2. Melo MR, Purini MC, Cançado RD, Kooro F, Chiattone CS. Uso de índices hematimétricos no diagnóstico diferencial de anemias microcíticas: uma abordagem a ser adotada? Rev Assoc Med Bras. 2002;48(3):222-4.
3. Bessman JD, Gilmer PR Jr, Gardner FH. Improved classification of anemias by MCV and RDW. Am J Clin Pathol. 1983;80(3):322-6.
4. Clarke GM, Higgins TN. Laboratory investigation of hemoglobinopathies and thalassemias: review and update. Clin Chem. 2000;46(8 Pt 2):1284-90.
5. Green R, King R. A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood Cells. 1989;15(3):481-91.
6. Aslan D, Gümrük F, Gürgey A, Altay C. Importance of RDW value in differential diagnosis of hypochrome anemias. Am J Hematol. 2002;69(1):31-3.
7. Karnad A, Poskitt TR. The automated complete blood cell count. Use of the red blood cell volume distribution width and mean platelet volume in evaluating anemia and thrombocytopenia. Arch Intern Med. 1985;145(7):1270-2.
8. Giles C. The platelet count and mean platelet volume. Br J Haematol. 1981;48(1):31-7.
9. Dan K. Thrombocytosis in iron deficiency anemia. Intern Med. 2005;44(10):1025-6.
10. Trent RJ. Diagnosis of the haemoglobinopathies. Clin Biochem Rev. 2006;27(1):27-38.
11. Bessman JD, Feinstein DI. Quantitative anisocytosis as a discriminant between iron deficiency and thalassemia minor. Blood. 1979;53(2):288-93.
12. Yermiahu T, Ben-Shalom M, Porath A, Vardi H, Boantza A, Mazor D et al. Quantitative determinations of microcytic-hypochromic red blood cell population and glycerol permeability in iron-deficiency anemia and beta thalassemia minor. Ann Hematol. 1999;78(10):468-71.
13. Flynn MM, Reppun TS, Bhagavan NV. Limitations of red blood cell distribution width (RDW) in evaluation of microcytosis. Am J Clin Pathol. 1986;85(4):445-9.
14. Eldibany MM, Totonchi KF, Joseph NJ, Rhone D. Usefulness of certain red blood cell indices in diagnosing and differentiating thalassemia trait from iron-deficiency anemia. Am J Clin Pathol. 1999;111(5):676-82.
15. Alfadhli SM, Al-Awadhi AM, AlKhaldi D. Validity assessment of nine discriminant functions used for the differentiation between iron deficiency anemia and thalassemia minor. J Trop Pediatr. 2007;53(2):93-7.
16. Ntaios G, Chatzinikolaou A, Saouli Z, Girtovitis F, Tsapanidou M, Kaiafa G et al. Discrimination indices as screening tests for beta-thalassemic trait. Ann Hematol. 2007;86(7):487-91.
17. Beyan C, Kaptan K, Ifran A. Predictive value of discrimination indices in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. Eur J Haematol. 2007;78(6):524-6.
18. Lafferty JD, Crowther MA, Ali MA, Levine M. The evaluation of various mathematical RBC indices and their efficacy in discriminating between thalassemic and non-thalassemic microcytosis. Am J Clin Pathol. 1996;106(2):201-5.
19. Tillyer ML, Tillyer CR. Use of red cell distribution width and erythrocyte zinc protoporphyrin in differential diagnosis of α and β thalassaemia and iron deficiency. J Clin Pathol. 1994;47(3):205-8.
20. Demir A, Yarali N, Fisgin T, Duru F, Kara A. Most reliable índices in differentiation between thalassemia trait and iron deficiency anemia. Pediatr Int. 2002;44(6):612-6.
21. Lima CS, Reis AR, Grotto HZ, Saad ST, Costa FF. Comparison of red cell distribution width and a red cell discriminant function incorporating volume dispersion for distinguishing iron deficiency from beta thalassemia trait in patients with microcytosis. Sao Paulo Med J. 1996;114(5):1265-9.
22. Timuragaoglu A, Coban E, Erbasan F. The importance of platelet indexes in discriminating between beta-thalassemia trait and iron deficiency anemia. Haematol. 2004;111(4):235-6.
23. Sharpe PC, Desai ZR, Morris TC. Increase in mean platelet volume in patients with chronic renal failure treated with erythropoietin. J Clin Pathol. 1994;47(2):159-61.
24. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG, Koutroubakis IE et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol. 2001;96(3):776-81.
25. Ishibashi T, Koziol JA, Burstein SA. Human recombinant erythropoietin promotes differentiation of murine mega-karyocytes in vitro. J Clin Invest. 1987;79(1):286-9.
26. Carrington PA, Hill RJ, Stenberg PE, Levin J, Corash L, Schreurs J et al. Multiple in vivo effects of interleukin-3 and interleukin-6 on murine megakaryocytopoiesis. Blood. 1991;77(1):34-41.
27. Hill RJ, Warren MK, Stenberg P, Levin J, Corash L, Drummond R et al. Stimulation of megakaryocytopoiesis in mice by human recombinant interleukin-6. Stimulation of megakaryocytopoiesis in mice by human recombinant interleukin-6. Blood. 1991;77(1):42-8.
28. Teramura M, Kobayashi S, Hoshino S, Oshimi K, Mizoguchi H. Interleukin-11 enhances human megakaryocytopoiesis in vitro. Blood. 1992;79(2):327-31.
29. Dan K, Gomi S, Inokuchi K, Ogata K, Yamada T, Ohki I et al. Effects of interleukin-1 and tumor necrosis factor on megakaryocytopoiesis: mechanism of reactive thrombocytosis. Acta Haematol. 1995;93(2-4):67-72.
30. Kaushansky K. Thrombopoietin. N Engl J Med. 1998;339(11):746-54.
31. Tozkoparan E, Deniz O, Ucar E, Bilgic H, Ekiz K. Changes in platelet count and indices in pulmonary tuberculosis. Clin Chem Lab Med. 2007;45(8):1009-13.
32. England JM, Fraser PM. Differentiation of iron deficiency from thalassaemia trait by routine blood-count. Lancet. 1973;1(7801):449-52.
33. Cavaliere TA. Red blood cell indices: implications for practice. Newborn Infant Nurs Rev. 2004;4(4):231-9.
34. a ed. Porto Alegre: Artmed, 2003. 298p.