Tissue pO2 of Orthotopic 9L and C6 Gliomas and Tumor-Specific Response to Radiotherapy and Hyperoxygenation

International Journal of Radiation Oncology Biology Physics

Volumn 73, Issue 3, 2009, Pages 878-885

  Khan, Nadeem ^a,b   Li, Hongbin ^a   Hou, Huagang ^a,b   Lariviere, Jean P ^a   Gladstone, David J ^b   Demidenko, Eugene ^a,b   Swartz, Harold M ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

Carbogen; Electron paramagnetic resonance oximetry; EPR oximetry; Glioma; partial pressure of oxygen; pO2; Radiotherapy

Indexed keywords

ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRONS; MAGNETIC RESONANCE; MERCURY (METAL); OXIMETERS; OXYGEN; OXYGENATION; PARAMAGNETIC MATERIALS; PARAMAGNETISM; QUANTUM THEORY; RADIATION EFFECTS; RADIOTHERAPY; RATS; RESONANCE; TISSUE; TUMORS;

CARBOGEN; ELECTRON PARAMAGNETIC RESONANCE OXIMETRY; EPR OXIMETRY; GLIOMA; PARTIAL PRESSURE OF OXYGEN; PO2;

PARAMAGNETIC RESONANCE;

CARBOGEN; CARBON DIOXIDE; OXYGEN; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TUMOR; BREATHING; CANCER RADIOTHERAPY; DOSIMETRY; ELECTRON PARAMAGNETIC RESONANCE OXIMETRY; GLIOMA; HYPEROXIA; HYPOXIA; LEFT HEMISPHERE; NONHUMAN; OXIMETRY; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RADIATION DOSE; RADIATION RESPONSE; RAT; TREATMENT RESPONSE; ANIMAL; CELL HYPOXIA; CHI SQUARE DISTRIBUTION; ELECTRON SPIN RESONANCE; FISCHER 344 RAT; METABOLISM; METHODOLOGY; OXYGEN CONSUMPTION; PATHOLOGY; PRESSURE; TUMOR VOLUME; WISTAR RAT;

ANIMALS; BRAIN NEOPLASMS; CARBON DIOXIDE; CELL HYPOXIA; CHI-SQUARE DISTRIBUTION; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLIOMA; OXIMETRY; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; RATS; RATS, INBRED F344; RATS, WISTAR; TUMOR BURDEN;

EID: 59649129205     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.10.025     Document Type: Article

References (30)

1. Stieber V.W., and Mehta M.P. Advances in radiation therapy for brain tumors. Neurol Clin 25 (2007) 1005-1033
2. Tatum J.L., Kelloff G.J., Gillies R.J., et al. Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol 82 (2006) 699-757
3. Vaupel P. Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis. Oncologist 13 Suppl. 3 (2008) 21-26
4. Hall E.J. Radiobiology for the radiologist. 5th ed. (2000), Lippincott Williams & Wilkins, Philadelphia p. 588
5. Jensen R.L. Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures. Neurosurg Focus 20 (2006) E24
6. Kaanders J.H., Bussink J., and van der Kogel A.J. ARCON: A novel biology-based approach in radiotherapy. Lancet Oncol 3 (2002) 728-737
7. 2 in tumors in response to carbogen breathing. Int J Radiat Oncol Biol Phys 42 (1998) 855-859
8. Dunn T.J., Braun R.D., Rhemus W.E., et al. The effects of hyperoxic and hypercarbic gases on tumor blood flow. Br J Cancer 80 (1999) 117-126
9. 2 measurements by electron paramagnetic resonance oximetry: Current status and future potential for experimental and clinical studies. Antioxid Redox Signal 9 (2007) 1169-1182
10. Williams B.B., Hou H., Grinberg O.Y., et al. High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat. Antioxid Redox Signal 9 (2007) 1691-1698
11. Barth R.F. Rat brain tumor models in experimental neuro-oncology: The 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas. J Neurooncol 36 (1998) 91-102
12. Dai C., and Holland E.C. Glioma models. Biochim Biophys Acta 1551 (2001) M19-M27
13. Swartz H.M., and Clarkson R.B. The measurement of oxygen in vivo using EPR techniques. Phys Med Biol 43 (1998) 1957-1975
14. 2 by EPR oximetry in rodents: Effects of anesthesia, ischemia, and breathing gas. Brain Res 685 (1995) 91-98
15. Rolett E.L., Azzawi A., Liu K.J., et al. Critical oxygen tension in rat brain: A combined (31)P-NMR and EPR oximetry study. Am J Physiol Regul Integr Comp Physiol 279 (2000) R9-R16
16. Hou H., Khan N., O'Hara J.A., et al. Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys 61 (2005) 1503-1509
17. Denekamp J., Waites T., and Fowler J.F. Predicting realistic RBE values for clinically relevant radiotherapy schedules. Int J Radiat Biol 71 (1997) 681-694
18. Fowler J.F. Modelling altered fractionation schedules. BJR Suppl 24 (1992) 187-192
19. Hou H., Grinberg O.Y., Grinberg S.A., et al. Cerebral tissue oxygenation in reversible focal ischemia in rats: Multi-site EPR oximetry measurements. Physiol Meas 26 (2005) 131-141
20. O'Hara J.A., Hou H., Demidenko E., et al. Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxia. Physiol Meas 26 (2005) 203-213
21. Demidenko E. Mixed models: Theory and applications Vol. 734 (2004), John Wiley & Sons, New York
22. Demidenko E. The assessment of tumor response to treatment. Appl Stat A55 (2006) 365-377
23. Cerniglia G.J., Wilson D.F., Pawlowski M., et al. Intravascular oxygen distribution in subcutaneous 9L tumors and radiation sensitivity. J Appl Physiol 82 (1997) 1939-1945
24. Teicher B.A., Herman T.S., and Rose C.M. Effect of Fluosol-DA on the response of intracranial 9L tumors to X rays and BCNU. Int J Radiat Oncol Biol Phys 15 (1988) 1187-1192
25. Teicher B.A., Holden S.A., Ara G., et al. Influence of an anti-angiogenic treatment on 9L gliosarcoma: Oxygenation and response to cytotoxic therapy. Int J Cancer 61 (1995) 732-737
26. Wallen C.A., Michaelson S.M., and Wheeler K.T. Evidence for an unconventional radiosensitivity of rat 9L subcutaneous tumors. Radiat Res 84 (1980) 529-541
27. Guerin C., Laterra J., Drewes L.R., et al. Vascular expression of glucose transporter in experimental brain neoplasms. Am J Pathol 140 (1992) 417-425
28. Beppu T., Kamada K., Yoshida Y., et al. Change of oxygen pressure in glioblastoma tissue under various conditions. J Neurooncol 58 (2002) 47-52
29. Ross B.D., Zhao Y.J., Neal E.R., et al. Contributions of cell kill and posttreatment tumor growth rates to the repopulation of intracerebral 9L tumors after chemotherapy: An MRI study. Proc Natl Acad Sci USA 95 (1998) 7012-7017
30. Vogelbaum M.A., Tong J.X., Higashikubo R., et al. Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside. Neurosurg Focus 3 (1997) Article 3