Smoke and mirrors: HIV-related lung cancer

Current Opinion in Oncology

Volumn 20, Issue 5, 2008, Pages 529-533

  Bazoes, Alexandra ^a   Bower, Mark ^b   Powles, Thomas ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

Highly active antiretroval therapy; HIV; Lung cancer

Indexed keywords

ANTIRETROVIRUS AGENT; CARBOPLATIN; DIDANOSINE; GEMCITABINE; PACLITAXEL; RITONAVIR; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BONE MARROW SUPPRESSION; CANCER INCIDENCE; DRUG SAFETY; DRUG TOLERABILITY; EARLY DIAGNOSIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIFE EXPECTANCY; LUNG CANCER; LUNG NON SMALL CELL CANCER; MORTALITY; NEUROTOXICITY; PRIORITY JOURNAL; REVIEW; SMOKING; TREATMENT OUTCOME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; LUNG TUMOR; SURVIVAL RATE;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; HIV INFECTIONS; HUMANS; LUNG NEOPLASMS; SMOKING; SURVIVAL RATE;

EID: 59649127631     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32830a4c99     Document Type: Review

References (36)

1. Stebbing J, Sanitt A, Teague A, et al. Prognostic significance of immune subset measurement in individuals with AIDS-associated Kaposi's sarcoma. J Clin Oncol 2007; 25:2230-2235.
2. Polesel J, Clifford GM, Rickenbach M, et al., Swiss HIV Cohort Study. Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy. AIDS 2008; 22:301-306.
3. Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 2007; 370:59-67. This meta-analysis shows a significant increase in the incidence of lung cancer in HIV and immunosuppressed transplant patients.
4. Powles T, Oliver T, Bower M. Non-AIDS-defining cancers in people with HIV infection: a sleeping giant? J HIV Ther 2006; 11:57-60.
5. Hoffman PC, Mauer AM, Vokes EE. Lung cancer. Lancet 2000; 355:479-485.
6. Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981; 66:1191-1308.
7. Frisch M, Biggar RJ, Engels EA, Goedert JJ, AIDS-Cancer Match Registry Study Group. Association of cancer with AIDS-related immunosuppression in adults. JAMA 2001; 285:1736-1745.
8. Parker MS, Leveno DM, Campbell TJ, et al. AIDS-related bronchogenic carcinoma: fact or fiction? Chest 1998; 113:154-161.
9. Tenholder MF, Jackson HD. Bronchogenic carcinoma in patients seropositive for human immunodeficiency virus. Chest 1993; 104:1049-1053.
10. Herida M, Mary-Krause M, Kaphan R, et al. Incidence of non-AIDS-defining cancers before and during the highly active antiretroviral therapy era in a cohort of human immunodeficiency virus-infected patients. J Clin Oncol 2003; 21:3447-3453.
11. Engels EA, Brock MV, Chen J, et al. Elevated incidence of lung cancer among HIV-infected individuals. J Clin Oncol 2006; 24:1383-1388.
12. Powles T, Thirwell C, Newsom-Davis T, et al. Does HIV adversely influence the outcome in advanced nonsmall-cell lung cancer in the era of HAART? Br J Cancer 2003; 89:457-459.
13. Bower M, Powles T, Nelson M, et al. HIV-related lung cancer in the era of highly active antiretroviral therapy. AIDS 2003; 17:371-375.
14. Tirelli U, Spina M, Sandri S, et al. Lung carcinoma in 36 patients with human immunodeficiency virus infection. The Italian Cooperative Group on AIDS and Tumors. Cancer 2000; 88:563-569.
15. Sridhar KS, Flores MR, Raub WA Jr, Saldana M. Lung cancer in patients with human immunodeficiency virus infection compared with historic control subjects. Chest 1992; 102:1704-1708.
16. Newnham A, Harris J, Evans HS, et al. The risk of cancer in HIV-infected people in southeast England: a cohort study. Br J Cancer 2005; 92:194-200.
17. Dal Maso L, Franceschi S, Polesel J, et al., Cancer and AIDS Registry Linkage Study. Risk of cancer in persons with AIDS in Italy, 1985-1998. Br J Cancer 2003; 89:94-100.
18. Clifford GM, Polesel J, Rickenbach M, et al., Swiss HIV Cohort. Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J Natl Cancer Inst 2005; 97:425-432.
19. Engels EA, Pfeiffer RM, Goedert JJ, et al., for the HIV/AIDS Cancer Match Study. Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS 2006; 20:1645-1654.
20. Long JL, Engels EA, Moore RD, Gebo KA. Incidence and outcomes of malignancy in the HAART era in an urban cohort of HIV-infected individuals. AIDS 2008; 22:489-496. This work tells us that outcome of HIV-related lung cancer may have improved in the HAART era.
21. Brock MV, Hooker CM, Engels EA, et al. Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. J Acquir Immune Defic Syndr 2006; 43:47-55.
22. Lewden C, Salmon D, Morlat P, et al., Mortality 2000 study group. Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS. Int J Epidemiol 2005; 34:121-130.
23. Kirk GD, Merlo C, O'Driscoll P, et al. HIV infection is associated with an increased riskfor lung cancer, independent of smoking. Clin Infect Dis 2007; 45:103-110. This work tell us that although smoking may in part explain the increased risk, there are further factors, as yet unexplained, which predispose individuals with HIV to lung cancer.
24. Spano JP, Massiani MA, Bentata M, et al. Lung cancer in patients with HIV infection and review of the literature. Med Oncol 2004; 21:109-115.
25. Savès M, Chêne G, Ducimetière P, et al., French WHO MONICA Project and the APROCO (ANRS EP11) Study Group. Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population. Clin Infect Dis 2003; 37:292-298.
26. Gordon SB, Janoff EN, Sloper D, et al. HIV-1 infection is associated with altered innate pulmonary immunity. J Infect Dis 2005; 192:1412-1416.
27. Agostini C, Sancetta R, Cerutti A, Semenzato G. Alveolar macrophages as a cell source of cytokine hyperproduction in HIV-related interstitial lung disease. J Leukoc Biol 1995; 58:495-500.
28. Allard JP, Aghdassi E, Chau J, et al. Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection. Am J Clin Nutr 1998; 67:143-147.
29. Buhl R, Jaffe HA, Holroyd KJ, et al. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 1989; 2:1294-1298.
30. Wistuba II, Behrens C, Milchgrub S, et al. Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects. JAMA 1998; 279:1554-1559.
31. Hakimian R, Fang H, Thomas L, Edelman MJ. Lung cancer in HIV-infected patients in the era of highly active antiretroviral therapy. J Thorac Oncol 2007; 2:268-272. This is the largest series of HIV-related lung cancer patients in the post-HAART era. It suggests the outcome for these patients remains poor and curative therapy should be offered wherever possible.
32. Vyzula R, Remick SC. Lung cancer in patients with HIV-infection. Lung Cancer 1996; 15:325-339.
33. Hessol NA, Pipkin S, Schwarcz S, et al. The impact of highly active antiretroviral therapy on non-AIDS-defining cancers among adults with AIDS. Am J Epidemiol 2007; 165:1143-1153.
34. Bridges BB, Thomas L, Hausner PF, et al. Phase II trial of gemcitabine/carboplatin followed by paclitaxel in patients with performance status=2,3 or other significant co-morbidity (HIV infection or s/p organ transplantation) in advanced nonsmall cell lung cancer. Lung Cancer 2008 [Epub ahead of print]. This is the most informative piece of work (along with reference [12]) regarding how patients with HIV tolerate therapy.
35. White CS, Haramati LB, Elder KH, et al. Carcinoma of the lung in HIV-positive patients: findings on chest radiographs and CT scans. AJR Am J Roentgenol 1995; 164:593-597.
36. James JS. Lung cancer: very high death rate with HIV, huge reduction possible with CT screening for early diagnosis. AIDS Treat News 2006; (420):5-6.