Safety of saccharin

Agro Food Industry Hi-Tech

Volumn 19, Issue 6, 2008, Pages 24-28

  Cohen, Samuel M ^a,b   Arnold, Lora L ^a   Emerson, James L ^c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b Havlik Wall Department of Oncology   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLADDER CANCERS; CANCER RISK; FEMALE RAT; HIGH DOSE; MALE RATS; SODIUM SACCHARINES; TOXICOLOGICAL EVALUATION; URINARY BLADDER;

DISEASES; RATS; RISK ASSESSMENT; SUGARS;

SUGAR SUBSTITUTES;

RATTUS;

EID: 59649114742     PISSN: 17226996     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. D. Arnold, D. Krewski et al., "Saccharin: a toxicological and historical perspective", Toxicology, 27, pp. 179-256 (1983).
2. L. Ellwein, S.Cohen, "The health risks of saccharin revisited", Crit. Rev. Toxicol. 20, pp. 311-326 (1990).
3. IARC. Consensus report. International Agency for Research on Cancer IARC Scientific Publications, 147. pp. 1-32 (1999).
4. International Agency for Research on Cancer. Saccharin and its salts. IARC Scientific Publications Monograph Series, 73. pp. 517-624 (1999).
5. S. Cohen. L. Ellwein, "Cell proliferation in carcinogenesis". Science, 249, pp. 1007-1011(1990).
6. G. Schoenig, E. Goldenthal et al., "Evaluation of the dose response and in utero exposure to saccharin in the rat", Food Chem. Toxicol., 23, pp. 475-490 (1985).
7. D. Kirkland, S. Pfuhler et al., "How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop", Mutat. Res. 628, pp. 31-55 (2007).
8. S. Cohen, Calcium phosphate-containing urinary precipitate in rat urinary bladder carcinogenesis. IARC Scientific Publications, 147, pp. 175-189 (1999).
9. S. Cohen, M. Cano et al., "Urinary and urothelial effects of sodium salts In male rats", Carcinogenesis, 16, pp. 343-348 (1995).
10. S. Cohen, L. Arnold et al. Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats. Carcinogenesis. 21, 783-792 (2000).
11. J.M. DeSesso, "Confounding factors in direct bladder exposure studies", Comments on Toxicology, 3, pp. 317-334 (1989).
12. D. Clayson, "Bladder carcinogenesis in rats and mice: Possibility of artifacts", J. Natl. Cancer Inst., 52, pp. 1685-1689 (1974).
13. S. Cohen, "The role of urinary physiology and chemistry in bladder carcinogenesis", Food Chem. Toxicol., 33, pp. 715-730 (1995).
14. S. Fukushima, A. Haglwara et al., "Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-N-butyl-(4-hydroxybutyl)amine", Food Chem. Toxicol . 21, pp. 59-68 (1983).
15. M. Elcock, R. Morgan, "Update on artificial sweeteners and bladder cancer", Regul. Toxicol. Pharmacol., 17, pp. 35-43 (1993).