Gene and protein expression profiling of the fat-1 mouse brain

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 80, Issue 1, 2009, Pages 33-42

  Ménesi, Dalma ^a   Kitajka, Klára ^a   Molnár, Eszter ^a   Kis, Zoltán ^a   Belleger, Jérome ^b   Narce, Michael ^b   Kang, Jing X ^c   Puskás, László G ^a   Das, Undurti N ^d,e  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UND LIFE SCIENCES   (United States)

^e Bharati Vidyapeeth's Medical College   (India)

Author keywords

Alzheimer's disease; Fat 1; Gene expression; Inflammation; Neuronal dysfunction; Polyunsaturated fatty acids

Indexed keywords

DOCOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; UNSATURATED FATTY ACID;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTHMA; BRAIN; CAENORHABDITIS ELEGANS; CHEMICAL BOND; DNA MICROARRAY; FAT 1 GENE; FATTY ACID METABOLISM; GENE; GENE EXPRESSION PROFILING; GENETIC ENGINEERING; HIPPOCAMPUS; MALE; MICROARRAY ANALYSIS; MOUSE; NERVE CELL DEGENERATION; NERVE CELL GROWTH; NEUROMODULATION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MICROARRAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; SYNAPTOGENESIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BRAIN; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; FATTY ACID DESATURASES; FATTY ACIDS, UNSATURATED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ARRAY ANALYSIS;

CAENORHABDITIS ELEGANS; MUS; MUS MUSCULUS;

EID: 59649101644     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2008.11.006     Document Type: Article

References (75)

1. Saldeen P., and Saldeen T. Omega-3 fatty acids: structure, function, and relation to the metabolic syndrome, infertility, and pregnancy. Metab. Syndr. Rel. Disord. 4 (2006) 138-148
2. U.N. Das, Essential fatty acids: biochemistry, physiology, and pathology, Biotech. J. 1 (2006) 420-439.
3. Das U.N. Essential fatty acids-a review. Curr. Pharm. Biotechnol. 7 (2006) 467-482
4. Kang J.X., Wang J., Wu L., and Kang Z.B. Fat-1 mice convert n-6 to n-3 fatty acids. Nature 427 (2004) 504
5. Kang J.X. Fat-1 transgenic mice: a new model for omega-3 research. Prostaglandins Leukot. Essent. Fatty Acids 77 (2007) 263-267
6. Kitajka K., Puskas L.G., Zvara A., Hackler Jr. L., Barceló-Coblijn G., Yeo Y.K., and Farkas T. The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. Proc. Natl. Acad. Sci. USA 99 (2002) 2619-2624
7. Puskas L.G., Kitajka K., Nyakas C., and Farkas T. Short-term administration of omega-3 fatty acids results in elevated transthyretin transcription in old rat hippocampus. Proc. Natl. Acad. Sci. USA 100 (2003) 1580-1585
8. Kitajka K., Sinclair A.J., Weisinger R.S., Weisinger H.S., Mathai M., Jayasooriya A.P., Halver J.E., and Puskas L.G. Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression. Proc. Natl. Acad. Sci. USA 101 (2004) 10931-10936
9. Jayasooriya A.P., Ackland M.L., Mathai M.L., Sinclair A.J., Weisinger H.S., Weisinger R.S., Halver J.E., Kitajka K., and Puskás L.G. Perinatal omega-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood. Proc. Natl. Acad. Sci. USA 102 (2005) 7133-7138
10. Das U.N. Are polyunsaturated fatty acids useful in Alzheimer's disease?. Agric. Food Ind. Hi-Tech. 19 (2008) 27-30
11. Das U.N. Long-chain polyunsaturated fatty acids in the growth and development of the brain and memory. Nutrition 19 (2003) 62-65
12. Das U.N. Can perinatal supplementation of long-chain polyunsaturated fatty acids prevents schizophrenia in adult life?. Med. Sci. Monit. 10 (2004) HY33-HY37
13. Folch J., Lees M., and Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226 (1957) 497-509
14. Palotas A., Puskas L.G., Kitajka K., Palotas M., Molnar J., Pakaski M., Janka Z., Penke B., and Kalman J. The effect of citalopram on gene expression profile of Alzheimer lymphocytes. Neurochem. Res. 29 (2004) 1563-1570
15. Puskas L.G., Bereczki E., Santha M., Vigh L., Csanadi G., Spener F., Ferdinandy P., Onochy A., and Kitajka K. Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain. Biochimie 86 (2004) 817-824
16. Puskas L.G., Nagy Z.B., Giricz Z., Onody A., Csonka C., Kitajka K., Hackler Jr. L., Zvara A., and Ferdinandy P. Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study. FEBS Lett. 562 (2004) 99-104
17. Gotea V., and Ovcharenko I. DiRE: identifying distant regulatory elements of co-expressed genes. Nucleic Acids Res. May 17 (2008)
18. Zheng Q., and Wang X.-J. GOEAST: a web-based software toolkit for gene ontology enrichment analysis. Nucleic Acid Res. (2008) 1-6 10.1093/nar/gkn276
19. Das U.N., and Rao A.A. Gene expression profile in obesity and type 2 diabetes mellitus. Lipids Health Dis. 6 (2007) 35 10.1186/1476-511X-6-35
20. Darios F., and Davletov B. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature 440 (2006) 813-817
21. Spector A.A., and Yorek M.A. Membrane lipid composition and cellular function. J. Lipid Res. 26 (1985) 1015-1035
22. Loscalzo J., Freedman J., Rudd M.A., Barsky-Vasserman I., and Vaughan D.E. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis 7 (1987) 450-455
23. Miquerol L., Lopez S., Cartier N., Tulliez M., Raymondjean M., and Kahn A. Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas. J. Biol. Chem. 269 (1994) 8944-8951
24. Stoffel M., and Duncan S.A. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. Proc. Natl. Acad. Sci. USA 94 (1997) 13209-13214
25. Suresh Y., and Das U.N. Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of ω-3 fatty acids. Nutrition 19 (2003) 213-228
26. Suresh Y., and Das U.N. Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus: effect of ω-6 fatty acids. Nutrition 19 (2003) 93-114
27. Rajas F., Gautier A., Bady I., Montano S., and Mithieux G. Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha. J. Biol. Chem. 277 (2002) 15736-15744
28. Dhe-Paganon S., Duda K., Iwamoto M., Chi Y.I., and Shoelson S.E. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J. Biol. Chem. 277 (2002) 37973-37976
29. Wisely G.B., Miller A.B., Davis R.G., Thornquest Jr. A.D., Johnson R., Spitzer T., Sefler A., Shearer B., Moore J.T., Miller A.B., Willson T.M., and Williams S.P. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure 10 (2002) 1225-1234
30. Grigo K., Wirsing A., Lucas B., Klein-Hitpass L., and Ryffel G.U. HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells. Biol. Chem. 389 (2008) 179-187
31. Erickson R.L., Hemati N., Ross S.E., and MacDougald O.A. p300 coactivates the adipogenic transcription factor CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 276 (2001) 16348-16355
32. Mansouri A., Hallonet M., and Gruss P. Pax genes and their roles in cell differentiation and development. Curr. Opin. Cell Biol. 8 (1996) 851-857
33. Kordula T., and Travis J. The role of Stat and C/EBP transcription factors in the synergistic activation of rat serine protease inhibitor-3 gene by interleukin-6 and dexamethasone. Biochem. J. 313 (1996) 1019-1027
34. Uryu S., Tokuhiro S., and Oda T. Beta-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages. Biochem. Biophys. Res. Commun. 303 (2003) 302-305
35. Unger T., Korade Z., Lazarov O., Terrano D., Schor N.F., Sisodia S.S., and Mirnics K. Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice. Am. J. Geriatr. Psychiatry 13 (2005) 1041-1051
36. Ntambi J.M., and Bene H. Polyunsaturated fatty acid regulation of gene expression. J. Mol. Neurosci. 16 (2001) 273-278
37. Kramer J.A., LeDeaux J., Butteiger D., Young T., Crankshaw C., Harlow H., Kier L., and Bhat B.G. Transcription profiling in rat liver in response to dietary docosahexaenoic acid implicates stearoyl-coenzyme a desaturase as a nutritional target for lipid lowering. J. Nutr. 133 (2003) 57-66
38. Gamoh S., Hashimoto M., Hossain S., and Masumura S. Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. Clin. Exp. Pharmacol. Physiol. 28 (2001) 266-270
39. Lim G.P., Calon F., Morihara T., Yang F., Teter B., Ubeda O., Salem Jr. N., Frautschy S.A., and Cole G.M. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J. Neurosci. 25 (2005) 3032-3040
40. Hashimoto M., Hossain S., Shimada T., and Shido O. Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity. Clin. Exp. Pharmacol. Physiol. 33 (2006) 934-939
41. Lovell M.A., Lynn B.C., Xiong S., Quinn J.F., Kaye J., and Markesbery W.R. An aberrant protein complex in CSF as a biomarker of Alzheimer disease. Neurology 70 (2008) 2212-2218
42. Raederstorff D., and Moser U. Influence of an increased intake of linoleic acid on the incorporation of dietary (n-3) fatty acids in phospholipids and on prostanoid synthesis in rat tissues. Biochim. Biophys. Acta 1165 (1992) 194-200
43. Shiraishi Y., Asano K., Niimi K., Fukunaga K., Wakaki M., Kagyo J., Takihara T., Ueda S., Nakajima T., Oguma T., Suzuki Y., Shioma T., Sayama K., Kagawa S., Ikeda E., Hirai H., Nagata K., Nakamura M., Miyasho T., and Ishizaka A. Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. J. Immunol. 180 (2008) 541-549
44. Tomasoni S., Noris M., Zappella S., Gotti E., Casiraghi F., Bonazzola S., Benigni A., and Remuzzi G. Upregulation of renal and systemic cyclooxygenase-2 in patients with active lupus nephritis. J. Am. Soc. Nephrol. 9 (1998) 1202-1212
45. Fink M.P. Prostaglandins and sepsis: still a fascinating topic despite almost 40 years of research. Am. J. Physiol. Lung Cell Mol. Physiol. 281 (2001) L534-L536
46. Bowman C.C., and Bost K.L. Cyclooxygenase-2-mediated prostaglandin E2 production in mesenteric lymph nodes and in cultured macrophages and dendritic cells after infection with Salmonella. J. Immunol. 172 (2004) 2469-2475
47. Das U.N. Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period?. J. Nutr. Biochem. 18 (2007) 701-713
48. Das U.N. Is obesity an inflammatory condition?. Nutrition 17 (2001) 953-966
49. Da U.N. Risk of type 2 diabetes mellitus in those with hypertension. Eur. Heart J. 29 (2008) 952-953
50. Das U.N. Is depression a low-grade systemic inflammatory condition?. Am. J. Clin. Nutr. 85 (2007) 1665-1666
51. Helmersson J., Vessby B., Larsson A., and Basu S. Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population. Circulation 109 (2004) 1729-1734
52. Bazan N.G., Colangelo V., and Lukiw W.J. Prostaglandins and other lipid mediators in Alzheimer's disease. Prostaglandins Other Lipid Mediat. 68-69 (2002) 197-210
53. Das U.N. A Perinatal Strategy for Preventing Adult Diseases: The Role of Long-chain Polyunsaturated Fatty Acids (2002), Kluwer Academic Publishers, Boston
54. Moses G.S., Jensen M.D., Lue L.F., Walker D.G., Sun A.Y., Simonyi A., and Sun G.Y. Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease. J. Neuroinflammat. 3 (2006) 28
55. Krakoff J., Funahashi T., Stehouwer C.D., Schalkwijk C.G., Tanaka S., Matsuzawa Y., Kobes S., Tataranni P.A., Hanson R.L., Knowler W.C., and Lindsay R.S. Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care 26 (2003) 1745-1751
56. Kawaguchi H., and Yasuda H. Increased phospholipase A2 activity in the kidney of spontaneously hypertensive rats. Arch. Biochem. Biophys. 248 (1986) 401-417
57. Tanaka Y., Meguro K., Yamaguchi S., Ishii H., Watanuki S., Funaki Y., Yamaguchi K., Yamadori A., Iwata R., and Itoh M. Decreased striatal D2 receptor density associated with severe behavioral abnormality in Alzheimer's disease. Ann. Nucl. Med. 17 (2003) 567-573
58. Li D., Sham P.C., Owen M.J., and He L. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum. Mol. Genet. 15 (2006) 2276-2284
59. Jenkinson C.P., Hanson R., Cray K., Wiedrich C., Knowler W.C., Bogardus C., and Baier L. Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians. Int. J. Obes. Relat. Metab. Disord. 24 (2000) 1233-1238
60. Prasad P., Kumar K.M., Ammini A.C., Gupta A., Gupta R., and Thelma B.K. Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. BMC Genet. 9 (2008) 26
61. Wang G.J., Volkow N.D., Logan J., Pappas N.R., Wong C.T., Zhu W., Netusil N., and Fowler J.S. Brain dopamine and obesity. Lancet 357 (2001) 354-357
62. Kuperstein F., Yakubov E., Dinerman P., Gil S., Evlam R., Salem Jr. N., and Yavin E. Overexpression of dopamine receptor genes and their products in the postnatal rat brain following maternal n-3 fatty acid dietary deficiency. J. Neurochem. 95 (2005) 1550-1562
63. Innis S.M., and de La Presa Owens S. Dietary fatty acid composition in pregnancy alters neurite membrane fatty acids and dopamine in newborn rat brain. J. Nutr. 131 (2001) 118-122
64. De La Presa Owens S., and Innis S.M. Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. J. Nutr. 129 (1999) 2088-2093
65. Belloir B., Kovari E., Surini-Demiri M., and Savioz A. Altered apolipoprotein D expression in the brain of patients with Alzheimer disease. J. Neurosci. Res. 64 (2001) 61-69
66. Johann A.M., Weigert A., Eberhardt W., Kuhn A.M., Barra V., von Knethen A., Pfeilschifter J.M., and Brune B. Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. J. Immunol. 180 (2008) 1239-1248
67. Mussig K., Remer T., Haupt A., Gallwitz B., Fritsche A., Haring H.U., and Aser-Gluth C. 11beta-hydroxysteroid dehydrogenase 2 activity is elevated in severe obesity and negatively associated with insulin sensitivity. Obesity (Silver Spring) 16 (2008) 1256-1260
68. De la Monte S.M., Tong M., Lester-Coll N., Plater Jr. M., and Wands J.R. Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease. J. Alzheimer's Dis. 10 (2006) 89-109
69. Sharon R., Goldberg M.S., Bar-Josef I., Betensky R.A., Shen J., and Selkoe D.J. Alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc. Natl. Acad. Sci. USA 98 (2001) 9110-9115
70. Perrin R.J., Woods W.S., Clayton D.F., and George J.M. Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J. Biol. Chem. 276 (2001) 41958-41962
71. Sharon R., Bar-Joseph I., Frosch M.P., Walsh D.M., Hamilton J.A., and Selkoe D.J. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 37 (2003) 583-595
72. Sharon R., Bar-Joseph I., Mirick G.E., Serhan C.N., and Selkoe D.J. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J. Biol. Chem. 278 (2003) 49874-49881
73. Quilty M.C., King A.E., Gai W.P., Pountney D.L., West A.K., Vickers J.C., and Dickson T.C. Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. Exp. Neurol. 199 (2006) 249-256
74. Golovko M.Y., Rosenberger T.A., Federsen S., Faergeman N.J., and Murphy E.J. Alpha-synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids. J. Neurochem. 101 (2007) 201-211
75. Adamczyk A., Kacprzak M., and Kazmierczak A. Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes. Folia Neuropathol. 45 (2007) 230-235