Adsorption mechanism of acids and bases in reversed-phase liquid chromatography in weak buffered mobile phases designed for liquid chromatography/mass spectrometry

Journal of Chromatography A

Volumn 1216, Issue 10, 2009, Pages 1776-1788

  Gritti, Fabrice ^a,b   Guiochon, Georges ^a,b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

C18 reversed phase columns; Column heterogeneity; Competitive adsorption isotherms; Nonlinear chromatography; Overloaded band profiles, acids and bases compounds; pKa of the analyte; Silanol activity; Silica; Weak buffer capacity

Indexed keywords

C18 REVERSED-PHASE COLUMNS; COLUMN HETEROGENEITY; COMPETITIVE ADSORPTION ISOTHERMS; NONLINEAR CHROMATOGRAPHY; OVERLOADED BAND PROFILES, ACIDS AND BASES COMPOUNDS; PKA OF THE ANALYTE; SILANOL ACTIVITY; WEAK BUFFER CAPACITY;

ACIDS; ADSORBENTS; ADSORPTION ISOTHERMS; ATMOSPHERIC TEMPERATURE; BUFFER STORAGE; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; EQUILIBRIUM CONSTANTS; IONIZATION OF LIQUIDS; ISOTHERMS; LIQUID CHROMATOGRAPHY; OXIDES; PHASE INTERFACES; PROBES; REAL TIME SYSTEMS; SILICA;

ADSORPTION;

4 TOLUIDINE; ACID; ANILINE; ARYLBUTYRIC ACID DERIVATIVE; BASE; CAFFEINE; CARBON; PHENETHYLACETIC ACID; PHENOL; SILICATE; TOLUIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; DISSOCIATION; EQUILIBRIUM CONSTANT; ISOTHERM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONTE CARLO METHOD; PH MEASUREMENT; PRIORITY JOURNAL; PROTON TRANSPORT; REVERSED PHASE LIQUID CHROMATOGRAPHY; THERMODYNAMICS;

ACIDS; ADSORPTION; ALGORITHMS; ANILINE COMPOUNDS; BUFFERS; CAFFEINE; CHROMATOGRAPHY, LIQUID; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; MODELS, CHEMICAL; MONTE CARLO METHOD; NONLINEAR DYNAMICS; PHENOL; SILANES; SILICON DIOXIDE; THERMODYNAMICS;

EID: 59649099234     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.10.064     Document Type: Article

References (42)

1. Unger K.K. Porous Silica (1979), Elsevier, Amsterdam, New York
2. Neue U.D. HPLC Columns. Theory, Technology, and Practice (1997), Wiley-VCH, New York
3. Melander W.R. In: Horváth Cs., and Horváth Cs. (Eds). High Performance Liquid Chromatography-Advances and Perspectives, vol. 2 (1980), Academic Press, New York 113
4. Horváth Cs., Melander W.R., and Molnar I. J. Chromatogr. 125 (1976) 129
5. Dorsey J.G., and Dill K.A. Chem. Rev. 89 (1989) 331
6. Dill K.A. J. Phys. Chem. 91 (1987) 1980
7. Gritti F., and Guiochon G. J. Chromatogr. A 1099 (2005) 1
8. Gritti F., and Guiochon G. Anal. Chem. 75 (2003) 5726
9. Gritti F., and Guiochon G. J. Chromatogr. A 1103 (2006) 57
10. Jaroniec M., and Madey R. Physical Adsorption on Heterogeneous Solids (1988), Elsevier, Amsterdam
11. Guiochon G., Shirazi S.G., Felinger A., and Katti A.M. Fundamentals of Preparative and Nonlinear Chromatography (2006), Academic Press, Boston, MA
12. Gritti F., and Guiochon G. J. Chromatogr. A 1155 (2007) 85
13. Gritti F., Kazakevich Y., and Guiochon G. J. Chromatogr. A 1169 (2007) 111
14. Kazakevich Y.V. J. Chromatogr. A 1126 (2006) 232
15. Lippa K.A., Sander L.C., and Mountain R.D. Anal. Chem. 77 (2005) 7852
16. Zhang L., Sun L., Siepmann J.I., and Schure M.R. J. Chromatogr. A 1079 (2005) 127
17. Zhang L., Rafferty J.L., Siepmann J.I., Chen B., and Schure M.R. J. Chromatogr. A 1126 (2006) 219
18. Rafferty J.L., Zhang L., Siepmann J.I., and Schure M.R. Anal. Chem. 79 (2007) 6551
19. Gritti F., and Guiochon G. J. Chromatogr. A 1028 (2004) 75
20. Danckwerts P.V. Chem. Eng. Sci. 2 (1953) 1
21. Rouchon P., Valentin P., Schonauer M., Vidal-Madjar C., and Guiochon G. J. Phys. Chem. 88 (1985) 2709
22. Rouchon P., Schonauer M., Valentin P., and Guiochon G. Sep. Sci. Technol. 22 (1987) 1793
23. Guiochon G., Golshan-Shirazi S., and Jaulmes A. Anal. Chem. 60 (1988) 1856
24. Stanley B.J., Bialkowski S.E., and Marshall D.B. Anal. Chem. 65 (1993) 259
25. Gritti F., and Guiochon G. Anal. Chem. 78 (2006) 5823
26. M.R. Schure, J. Rafferty, J.I. Siepmann, A molecular-level description of retention in reversed-phase liquid chromatography: a story with pictures, no equations and excellent agreement with experiment, Presented at the 32nd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Baltimore, MD, May 10-16, 2008, lecture.
27. Neue U.D., Van Tran K., Mendez A., and Carr P.W. J. Chromatogr. A 1063 (2005) 35
28. Neue U.D., Wheat T.E., Mazzeo J.R., Mazza C.B., Cavanaugh J.Y., Xia F., and Diehl D.M. J. Chromatogr. A 1030 (2004) 123
29. Mendez A., Bosch E., Roses M., and Neue U.D. J. Chromatogr. A 986 (2003) 33
30. Neue U.D., Phoebe C.H., Van Tran K., Cheng Y.-F., and Lu Z. J. Chromatogr. A 925 (2001) 49
31. Samuelsson J., Franz A., Stanley B.J., and Fornstedt T. J. Chromatogr. A 1163 (2007) 177
32. McCalley D.V. J. Chromatogr. A 1038 (2004) 77
33. Davies N.H., Euerby M.R., and McCalley D.V. J. Chromatogr. A 1119 (2006) 11
34. McCalley D.V. Anal. Chem. 78 (2006) 2532
35. Hägglund I., and Ståhlberg J. Anal. Chem. 60 (1988) 1958
36. Hägglund I., and Ståhlberg J. J. Chromatogr. A 761 (1997) 3
37. Hägglund I., and Ståhlberg J. J. Chromatogr. A 761 (1997) 13
38. F. Gritti, G. Guiochon, J. Sep. Sci., doi, in press.
39. F. Gritti, G. Guiochon, J. Chromatogr. A, in press.
40. Gritti F., and Guiochon G. J. Chromatogr. A 1103 (2006) 43
41. Gritti F., and Guiochon G. J. Chromatogr. A 1103 (2006) 69
42. Bosch E., Bou P., Allemann H., and Rosés M. Anal. Chem. 68 (1996) 3651