Impact of polyclonal anti-thymocyte globulins on the expression of adhesion and inflammation molecules after ischemia-reperfusion injury

Transplant Immunology

Volumn 20, Issue 4, 2009, Pages 224-228

  Beiras Fernandez, A ^a,b   Chappell, D ^a,b   Hammer, C ^a   Beiras, A ^c   Reichart, B ^b   Thein, E ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Adhesion molecules; Anti thymocyte globulins; Inflammation molecules; Ischemia; Reperfusion injury

Indexed keywords

CD11B ANTIGEN; CD31 ANTIGEN; CELL ADHESION MOLECULE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 6; PADGEM PROTEIN; RINGER LACTATE SOLUTION; THYMOCYTE ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY; ARTICLE; BIOPSY; CELL ADHESION; CONTROL GROUP; CONTROLLED STUDY; ENDOTHELIUM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOCYTE; LIMB ISCHEMIA; MONKEY; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; VEIN;

ANIMALS; ANTIGENS, CD11B; ANTILYMPHOCYTE SERUM; CELL ADHESION; CELL ADHESION MOLECULES; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MACACA FASCICULARIS; MUSCLE, SMOOTH, VASCULAR; REPERFUSION INJURY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 59649094303     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2008.11.004     Document Type: Article

References (29)

1. Massberg S., and Messmer K. The nature of ischemia-reperfusion injury. Transplant Proc 30 (1998) 4217-4223
2. Thiel M., Imendorffer S., Chouker A., Groh J., Briegel J., Anthuber M., et al. Expression of adhesion molecules on circulating polymorphonuclear leukocytes during orthotopic liver transplantation. Hepatology 28 (1998) 1538-1550
3. Yokota N., Daniels F., Crosson J., and Rabb H. Protective effect of T cell depletion in murine renal ischemia-reperfusion injury. Transplantation 74 6 (2002) 638-759
4. Luscinskas F.W., Ma S., Nusrat A., et al. Leukocyte transendothelial migration: a junctional affaire. Semin Immunol 14 (2002) 105-113
5. Menger M., Richter S., Yamauchi J., and Vollmar B. Role of microcirculation in hepatic ischemia/reperfusion injury. Hepatogastroenterology 46 Suppl 2 (1999) 1452-1457
6. Beiras-Fernandez A., Thein E., and Hammer C. Induction of immunosuppression with polyclonal antithymocyte globulins: an overview. Exp Clin Transplant 1 2 (2003 Dec) 79-84
7. Bourdage J.S., and Hamlin M.D. Comparative polyclonal antithymocyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry. Transplantation 59 (1995) 1194-1200
8. Michallet M.C., Preville X., Flacher M., Fournel S., Genestier L., and Revillard J.P. Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins. Transplantation 75 5 (2003) 657-662
9. Bonnefoy-Berard N., Vincent C., and Revillard J.P. Antibodies against functional leukocyte surface molecules in polyclonal antilymphocyte and antithymocyte globulins. Transplantation 51 (1991) 669-673
10. Beiras-Fernandez A., Chappell D., Hammer C., and Thein E. Influence of polyclonal anti-thymocyte globulins upon ischemia-reperfusion injury in a non-human primate model. Transpl Immunol 15 4 (2006) 273-279
11. Beiras-Fernandez A., Thein E., Chappell D., Gallego R., Vazquez-Roel D., Kemming G., et al. Polyclonal anti-thymocyte globulins influence apoptosis in reperfused tissues after ischemia in a non-human primate model. Transpl Int 17 8 (2004) 453-457 2004
12. Chappell D., Beiras-Fernandez A., Hammer C., and Thein E. In vivo visualisation of the effect of polyclonal antithymocyte globulins on the microcirculation after ischaemia/reperfusion in a primate model. Transplantation 81 4 (2006) 552-558
13. Thein E., Sevilmis G., Muenzing S., Hammer C., and Messmer K. Evaluation of a system for the perfusion of isolated, rodent organs. Xenotransplantation 8 (2001) 94-99
14. Hsu S.M., and Raine L. Protein A, avidin, and biotin in immunohistochemistry. J Histochem Cytochem 29 (1981) 1349-1353
15. Beiras-Fernandez A., Thein E., Chappell D., and Hammer C. Polyclonal antithymocyte globulins reduce the expression of IL-4 in a model of ischemia-reperfusion injury. Transpl Immunol 13 1 (2004) 9-13
16. Carden D.L., and Granger D.N. Pathophysiology of ischaemia-reperfusion injury. J Pathol 190 (2000) 255-266
17. Harris A.G., Leiderer R., Peer F., and Messmer K. Skeletal muscle microvascular and tissue injury after varying durations of ischemia. Am J Physiol 271 (1996) 2388-2398
18. Granger D.N., Benoit G.N., Suzuki M., and Grisham M.B. Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol 257 (1989) 683-688
19. Hernandez L.A., Grisham M.B., Twohig B., et al. Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol 253 (1987) 699-703
20. Harlan J.M., and Winn R.K. Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy. Crit Care Med 30 (2002) S214-219
21. Carrier M., White M., Perrault L.P., Pelletier G.B., Pellerin M., Robitaille D., et al. A 10-year experience with intravenous thymoglobuline in induction of immunosuppression following heart transplantation. J Heart Lung Transplant 18 (1999) 1218-1222
22. Cragg L., Blazar B.R., Defor T., Kolatker N., Miller W., Kersey J., et al. A randomized trial comparing prednisone with antithymocyte globulin/prednisone as an initial systemic therapy for moderately severe acute graft-versus-host disease. Biol Blood Marrow Transplant 6 (2000) 441-447
23. Tichelli A., Passweg J., Nissen C., Bargetzi M., Hoffmann T., Wodnar-Filipowicz A., et al. Repeated treatment with horse antilymphocyte globulin for severe aplastic anaemia. Br J Haematol 100 (1998) 393-400
24. Beiras-Fernandez A., Walther S., Kaczmarek I., Ngo T., Muenzing S., Hammer C., et al. In vitro influence of polyclonal anti-thymocyte globulins on leukocyte expression of adhesion molecules. Exp Clin Transplant 3 2 (2005 Dec) 370-374
25. Beiras-Fernandez A., Walther S., Muenzing S., Thein E., and Hammer C. In vitro assessment of dose-dependent platelet activation by polyclonal anti-thymocyte globulins: a flow-cytometric analysis. Transplantation 78 5 (2004) 751-754
26. Farooq M.M., Serra A., Newman P.J., Cambria R.A., Seabrook G.R., Towne J.B., et al. PECAM-1/IgG attenuates peroxynitrite-mediated extremity reperfusion injury. J Vasc Surg 34 (2001) 555-558
27. Korthuis R.J., Granger D.N., Townsley M.I., and Taylor A.E. The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability. Circ Res 57 (1985) 599-609
28. Behrend M. Immune-adhesion molecules in the prevention of allograft rejection and reperfusion injury. Expert Opin Investig Drugs 9 (2000) 789-805
29. Land W. Postischemic reperfusion injury and cytokines. Transplant Proc 30 (1998) 4237-4238