메뉴 건너뛰기




Volumn 10, Issue 1, 2009, Pages 37-49

Developmental toxicity of ochratoxin A in rat embryo midbrain micromass cultures

Author keywords

Computer image analysis; Developmental neurotoxicity; Embryonic midbrain cells; Immunocytochemistry; In vitro micromass cultures; Ochratoxin A

Indexed keywords

BETA TUBULIN; MICROTUBULE ASSOCIATED PROTEIN 2; NEUTRAL RED; OCHRATOXIN; TERATOGENIC AGENT;

EID: 59649092201     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms10010037     Document Type: Article
Times cited : (21)

References (47)
  • 1
    • 0028786105 scopus 로고
    • Developing brain as a target of toxicity
    • Rodier, P.M. Developing brain as a target of toxicity. Environ. Health Perspect. 1995, 103 (suppl 6), 73-76.
    • (1995) Environ. Health Perspect , vol.103 , Issue.SUPPL. 6 , pp. 73-76
    • Rodier, P.M.1
  • 2
    • 33845424655 scopus 로고    scopus 로고
    • Developmental neurotoxicity of industrial chemicals
    • Grandjean, P.; Lanndrigan, P.J. Developmental neurotoxicity of industrial chemicals. Lancet 2006, 368, 2167-2178.
    • (2006) Lancet , vol.368 , pp. 2167-2178
    • Grandjean, P.1    Lanndrigan, P.J.2
  • 4
    • 84892681425 scopus 로고    scopus 로고
    • In vitro systems to study developmental neurotoxicity of food contaminants
    • Ceccatelli, S.; Tamm, R.; Tofighi, R.; Johansson, C. In vitro systems to study developmental neurotoxicity of food contaminants. Toxicol. Lett. 2006, 164 (suppl), 24.
    • (2006) Toxicol. Lett , vol.164 , Issue.SUPPL. , pp. 24
    • Ceccatelli, S.1    Tamm, R.2    Tofighi, R.3    Johansson, C.4
  • 5
    • 0031733769 scopus 로고    scopus 로고
    • The role of ochratoxin A as a possible cause of Balkan endemic nephropathy and its risk evaluation
    • Stoev, S.D. The role of ochratoxin A as a possible cause of Balkan endemic nephropathy and its risk evaluation. Vet. Hum. Toxicol. 1998, 40, 352-360.
    • Vet. Hum. Toxicol , vol.1998 , Issue.40 , pp. 352-360
    • Stoev, S.D.1
  • 6
    • 33846454704 scopus 로고    scopus 로고
    • Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans
    • Pfohl-Leszkowicz, A.; Manderville R.A. Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans. Mol. Nutr. Food Res. 2007, 51, 61-99.
    • (2007) Mol. Nutr. Food Res , vol.51 , pp. 61-99
    • Pfohl-Leszkowicz, A.1    Manderville, R.A.2
  • 8
    • 0029029410 scopus 로고
    • Studies of the influence of ochratoxin A on immune and defence reactions in the mouse model
    • Mu″ller, G.; Kielstein, P; Ko″hler, H.; Berndt, A.; Rosner, H. Studies of the influence of ochratoxin A on immune and defence reactions in the mouse model. Mycoses 1995, 38, 85-91.
    • (1995) Mycoses , vol.38 , pp. 85-91
    • Mu″ller, G.1    Kielstein, P.2    Ko″hler, H.3    Berndt, A.4    Rosner, H.5
  • 9
    • 0032887475 scopus 로고    scopus 로고
    • Studies of the influence of ochratoxin A on immune and defence reactions in weaners
    • Mu″ller, G.; Kielstein, P; Rosner, H.; Berndt, A.; Heller, M; Ko″hler, H. Studies of the influence of ochratoxin A on immune and defence reactions in weaners. Mycoses 1999, 42, 495-505.
    • (1999) Mycoses , vol.42 , pp. 495-505
    • Mu″ller, G.1    Kielstein, P.2    Rosner, H.3    Berndt, A.4    Heller, M.5    Ko″hler, H.6
  • 10
    • 0017231458 scopus 로고
    • Prenatal effects of ochratoxin A in hamsters
    • Hood, R.D.; Naughton, M.J.; Hayes, A.W. Prenatal effects of ochratoxin A in hamsters. Teratology 1976, 13, 11-14.
    • (1976) Teratology , vol.13 , pp. 11-14
    • Hood, R.D.1    Naughton, M.J.2    Hayes, A.W.3
  • 11
    • 0020376068 scopus 로고
    • Embryocidal, fetotoxic and teratogenic effects of ochratoxin A in rats
    • Mayura, K.; Reddy, R.V.; Hayes, A.W.; Berndt, W.O. Embryocidal, fetotoxic and teratogenic effects of ochratoxin A in rats. Toxicology 1982, 25, 175-185.
    • (1982) Toxicology , vol.25 , pp. 175-185
    • Mayura, K.1    Reddy, R.V.2    Hayes, A.W.3    Berndt, W.O.4
  • 12
    • 0021224029 scopus 로고
    • Teratogenic effects of ochratoxin A in rats with impaired renal function
    • Mayura, K.; Stein, A.F.; Berndt, W.O.; Phillips, T.D. Teratogenic effects of ochratoxin A in rats with impaired renal function. Toxicology 1984, 32, 277-285.
    • (1984) Toxicology , vol.32 , pp. 277-285
    • Mayura, K.1    Stein, A.F.2    Berndt, W.O.3    Phillips, T.D.4
  • 13
    • 33749618148 scopus 로고    scopus 로고
    • Critical period and minimum single oral dose of ochratoxin A for inducing developmental toxicity in pregnant Wistar rats
    • Patil, R.D.; Dwivedi, P.; Sharma, A.K. Critical period and minimum single oral dose of ochratoxin A for inducing developmental toxicity in pregnant Wistar rats. Reprod. Toxicol. 2006, 22, 679-687.
    • (2006) Reprod. Toxicol , vol.22 , pp. 679-687
    • Patil, R.D.1    Dwivedi, P.2    Sharma, A.K.3
  • 14
    • 0027519358 scopus 로고
    • Pathogenesis of craniofacial and body wall malformations induced by ochratoxin A in mice
    • Wei, X.; Sulik, K.K. Pathogenesis of craniofacial and body wall malformations induced by ochratoxin A in mice. Am. J. Med. Genet. 1993, 47, 862-871.
    • (1993) Am. J. Med. Genet , vol.47 , pp. 862-871
    • Wei, X.1    Sulik, K.K.2
  • 15
    • 0020534310 scopus 로고
    • Postnatal behavioural effects of ochratoxin A in offspring of treated mice
    • Poppe, S.M.; Stuckhardt, J.L.; Szczech, G.M. Postnatal behavioural effects of ochratoxin A in offspring of treated mice. Teratology 1983, 27, 293-300.
    • (1983) Teratology , vol.27 , pp. 293-300
    • Poppe, S.M.1    Stuckhardt, J.L.2    Szczech, G.M.3
  • 16
    • 0024242992 scopus 로고
    • Neurochemical effects of prenatal treatment with ochratoxin A on fetal and adult mouse brain
    • Tamaru, M.; Hirata, Y.; Matsutani, T. Neurochemical effects of prenatal treatment with ochratoxin A on fetal and adult mouse brain. Neurochem. Res. 1988, 13, 1139-1147.
    • (1988) Neurochem. Res , vol.13 , pp. 1139-1147
    • Tamaru, M.1    Hirata, Y.2    Matsutani, T.3
  • 17
    • 0026783179 scopus 로고
    • Development of neurons and synapses in ochratoxin A-induced microcephalic mice: A quantitative assessment of somatosensory cortex
    • Fukui, Y.; Hayasaka, S.; Itoh, M.; Takeuchi, Y. Development of neurons and synapses in ochratoxin A-induced microcephalic mice: a quantitative assessment of somatosensory cortex. Neurotoxicol. Teratol. 1992, 14, 191-196.
    • (1992) Neurotoxicol. Teratol , vol.14 , pp. 191-196
    • Fukui, Y.1    Hayasaka, S.2    Itoh, M.3    Takeuchi, Y.4
  • 21
    • 17044431495 scopus 로고    scopus 로고
    • In vitro and other alternative approaches to developmental neurotoxicity testing (DNT)
    • Lein, P.; Silbergeld, E.; Locke, P.; Goldberg, A.M. In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environ. Toxicol. Pharmacol. 2005, 19, 735-744.
    • (2005) Environ. Toxicol. Pharmacol , vol.19 , pp. 735-744
    • Lein, P.1    Silbergeld, E.2    Locke, P.3    Goldberg, A.M.4
  • 22
    • 34249100959 scopus 로고    scopus 로고
    • Meeting report: Alternatives for developmental neurotoxicity testing
    • Lein, P.; Locke, P.; Goldberg, A. Meeting report: Alternatives for developmental neurotoxicity testing. Environ. Health Perspect. 2007, 115, 764-768.
    • (2007) Environ. Health Perspect , vol.115 , pp. 764-768
    • Lein, P.1    Locke, P.2    Goldberg, A.3
  • 23
    • 84892681454 scopus 로고    scopus 로고
    • In vitro Micromass Teratogen Assay
    • Available from
    • In vitro Micromass Teratogen Assay. INVITTOX n° 114. 1996. Available from http://ecvamdbalm.jrc.ec.europa.eu
    • (1996) INVITTOX , Issue.114
  • 26
    • 0020645551 scopus 로고
    • A micromass culture method for rat embryonic neural cells
    • Flint, O.P.: A micromass culture method for rat embryonic neural cells. J. Cell Sci. 1983, 61, 247-262.
    • (1983) J. Cell Sci , vol.61 , pp. 247-262
    • Flint, O.P.1
  • 27
    • 0021732321 scopus 로고
    • in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells
    • Flint, O.P.; Orton, T.C. An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells. Toxicol. Appl. Pharmacol. 1984, 76, 383-395.
    • (1984) Toxicol. Appl. Pharmacol , vol.76 , pp. 383-395
    • Flint, O.P.1    Orton, T.C.A.2
  • 28
    • 0027355045 scopus 로고
    • Neurodevelopmental toxicity in vitro: Primary cell culture models for screeening and risk assessment
    • Reinhardt, C.A. Neurodevelopmental toxicity in vitro: Primary cell culture models for screeening and risk assessment. Reprod. Toxicol. 1993, 7, 165-170.
    • (1993) Reprod. Toxicol , vol.7 , pp. 165-170
    • Reinhardt, C.A.1
  • 29
    • 0025123662 scopus 로고
    • Midbrain micromass cultures: A model for studies of teratogenic and sub-teratogenic effects on CNS development
    • Walum, E.; Flint, O.P. Midbrain micromass cultures: A model for studies of teratogenic and sub-teratogenic effects on CNS development. Acta Physiol. Scand. 1990, 592(suppl.1), 61-72.
    • (1990) Acta Physiol. Scand , vol.592 , Issue.SUPPL.1 , pp. 61-72
    • Walum, E.1    Flint, O.P.2
  • 30
    • 0027811110 scopus 로고
    • Characterization of cytoskeletal and neuronal markers in micromass cultures of rat embryonic midbrain cells
    • Whittaker, S.G.; Wroble, J.T.; Silbernagel, S.M.; Faustman, E.M. Characterization of cytoskeletal and neuronal markers in micromass cultures of rat embryonic midbrain cells. Cell Biol. Toxicol. 1993, 9, 359-375.
    • (1993) Cell Biol. Toxicol , vol.9 , pp. 359-375
    • Whittaker, S.G.1    Wroble, J.T.2    Silbernagel, S.M.3    Faustman, E.M.4
  • 31
    • 15744382901 scopus 로고
    • Preliminary studies on the use of in vitro rat micromass assay - Results with some model teratogens
    • Combes, R.D.; Innes, D. Preliminary studies on the use of in vitro rat micromass assay - Results with some model teratogens. Toxicologist 1990, 10, 125.
    • (1990) Toxicologist , vol.10 , pp. 125
    • Combes, R.D.1    Innes, D.2
  • 32
    • 0025005933 scopus 로고
    • In vitro micromass teratogen test: Interpretation of results from a blind trial of 25 compounds using three separate criteria
    • Parsons, J.F.; Rockley, J.; Richold, M. In vitro micromass teratogen test: Interpretation of results from a blind trial of 25 compounds using three separate criteria. Toxicol. In Vitro 1990, 4, 609 - 611.
    • (1990) Toxicol. In Vitro , vol.4 , pp. 609-611
    • Parsons, J.F.1    Rockley, J.2    Richold, M.3
  • 33
    • 2342579558 scopus 로고    scopus 로고
    • Discriminative power of an assay for. automated in vitro screening of teratogens
    • Walmod, P.S.; Gravemann, U.; Nau, H.; Berezin, V.; Bock, E. Discriminative power of an assay for. automated in vitro screening of teratogens. Toxicol. in Vitro 2004, 18, 511-525.
    • (2004) Toxicol. in Vitro , vol.18 , pp. 511-525
    • Walmod, P.S.1    Gravemann, U.2    Nau, H.3    Berezin, V.4    Bock, E.5
  • 35
    • 34447556898 scopus 로고    scopus 로고
    • Adult hipocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A
    • Sava, V.; Velasquez, A.; Song, S.; Sanchez-Ramos, J. Adult hipocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A. Toxicol. Sci. 2007, 98, 187-197.
    • (2007) Toxicol. Sci , vol.98 , pp. 187-197
    • Sava, V.1    Velasquez, A.2    Song, S.3    Sanchez-Ramos, J.4
  • 36
    • 13144293044 scopus 로고    scopus 로고
    • Ochratoxin A: The continuing enigma
    • O'Brien, E.; Dietrich, D.R. Ochratoxin A: The continuing enigma. Crit. Rev. Toxicol. 2005, 35, 33-60.
    • (2005) Crit. Rev. Toxicol , vol.35 , pp. 33-60
    • O'Brien, E.1    Dietrich, D.R.2
  • 37
    • 40749154276 scopus 로고    scopus 로고
    • Cytotoxicity of feed-borne mycotoxins to animal cell lines in vitro using MTT assay
    • Stec, J.; Szczotka, M.; Kuźmak, J. Cytotoxicity of feed-borne mycotoxins to animal cell lines in vitro using MTT assay. Bull. Vet. Inst. Pulawy 2007, 51, 679-684
    • (2007) Bull. Vet. Inst. Pulawy , vol.51 , pp. 679-684
    • Stec, J.1    Szczotka, M.2    Kuźmak, J.3
  • 38
    • 10044237965 scopus 로고    scopus 로고
    • Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells
    • Kamp, H.G.; Eisenbrand, G.; Schlatter, J.; WuPrime;rth, K.; Janzowski, C. Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells. Toxicology 2005, 206, 413-425.
    • (2005) Toxicology , vol.206 , pp. 413-425
    • Kamp, H.G.1    Eisenbrand, G.2    Schlatter, J.3    WuPrime4    rth, K.5    Janzowski, C.6
  • 43
    • 0842264755 scopus 로고    scopus 로고
    • Molecular multiple endpoint embryonic stem cell test - a possible approach to test for the teratogenic potential of compounds
    • Zur Nieden, N.I., Kempka, G., Ahr, H.J. Molecular multiple endpoint embryonic stem cell test - a possible approach to test for the teratogenic potential of compounds. Toxicol. Appl. Pharmacol. 2004, 194, 257-269.
    • (2004) Toxicol. Appl. Pharmacol , vol.194 , pp. 257-269
    • Zur Nieden, N.I.1    Kempka, G.2    Ahr, H.J.3
  • 45
    • 0031751625 scopus 로고    scopus 로고
    • Regional selectivity to ochratoxin A, didtribution and cytotoxicity in rat brain
    • Belmadani, A.; Tramu, G.; Betbeder, A.M.; Steyn, P.S.; Creppy, E.E. Regional selectivity to ochratoxin A, didtribution and cytotoxicity in rat brain. Arch. Toxicol. 1998, 72, 656-662.
    • (1998) Arch. Toxicol , vol.72 , pp. 656-662
    • Belmadani, A.1    Tramu, G.2    Betbeder, A.M.3    Steyn, P.S.4    Creppy, E.E.5
  • 46
    • 0032466780 scopus 로고    scopus 로고
    • Differences in neurotoxic effects of ochratoxin A, ochracin and ochratoxin-alpha in vitro
    • Bruinink, A.; Rasonyi, T.; Sidler, C. Differences in neurotoxic effects of ochratoxin A, ochracin and ochratoxin-alpha in vitro. Nat. Toxins 1998, 6, 173-177.
    • (1998) Nat. Toxins , vol.6 , pp. 173-177
    • Bruinink, A.1    Rasonyi, T.2    Sidler, C.3
  • 47
    • 23644432411 scopus 로고    scopus 로고
    • Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures
    • Zurych, M.G.; Lengacher, S.; Braissant, O.; Monnet-Tschudi, F.; Pellerin, L.; Honegger, P. Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. Neuroscience 2005, 134, 771-782.
    • (2005) Neuroscience , vol.134 , pp. 771-782
    • Zurych, M.G.1    Lengacher, S.2    Braissant, O.3    Monnet-Tschudi, F.4    Pellerin, L.5    Honegger, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.