Inhibition of endothelial nitric oxide synthase by C-reactive protein: clinical relevance

Clinical Chemistry

Volumn 55, Issue 2, 2009, Pages 206-208

  Jialal, Ishwarlal ^a   Verma, Subodh ^b   Devaraj, Sridevi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ANTIGEN ANTIBODY COMPLEX; BLOOD VESSEL REACTIVITY; EDITORIAL; ENZYME INHIBITION; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ANIMALS; C-REACTIVE PROTEIN; HEMODYNAMICS; HUMANS; HYPERTENSION; NITRIC OXIDE SYNTHASE TYPE III;

EID: 59649091215     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2008.119206     Document Type: Editorial

References (15)

1. Verma S, Wang CH, Li SH, Dumont AS, Fedak PW, Badiwala MV, et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 2002;106:913-9.
2. Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-Reactive protein decrease eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002;106:1439-41.
3. Dasu MR, Devaraj S, Du Clos TW, Jialal I. The biological effects of CRP are not attributable to endotoxin contamination: evidence from TLR4 knockdown human aortic endothelial cells. J Lipid Res 2007;48:509-12.
4. Singh U, Devaraj S, Vasquez-Vivar J, Jialal I. CRP decreases endothelial nitric oxide synthase via uncoupling. J Mol Cell Cardiol 2007;43:780-91.
5. Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, et al. FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase. Circ Res 2005;97:1124-31.
6. Schwedler SB, Kuhlencordt PJ, Ponnuswamy PP, Hatiboglu G, Quaschning T, Widder J, et al. Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species. Atherosclerosis 2007;195:e76-84.
7. Teoh H, Quan A, Lovren F, Wang G, Tirgari S, Szmitko PE, et al. Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis 2008;201:318-25.
8. Verma S, Devaraj S, Jialal I. C-reactive protein promotes atherothrombosis. Circulation 2006;113:2135-50.
9. Singh U, Dasu MR, Yancy PG, Afify A, Devaraj S, Jialal I. Human CRP promotes oxidized low density lipoprotein uptake and MMP-9 release in Wistar rats. J Lipid Res 2008;49:1015-23.
10. Devaraj S, Dasu MR, Singh U, Rao LV, Jialal I. C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo. Atherosclerosis. [Epub ahead of print 2008 Jun 13]
11. Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, et al. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature (Lond). 2006;440:1217-21.
12. Guan H, Wang P, Hui R, Edin ML, Zeldin DC, Wang DW. Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats. Clin Chem 2009;55:274-84.
13. Venugopal SK, Devaraj S, Jialal I. CRP decreases prostacyclin release from human aortic endothelial cells. Circulation 2003;108:1676-8.
14. Vongpatanasin W, Thomas GD, Schwartz R, Cassis LA, Osborne-Lawrence S, Hahner L, et al. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation 2007;115:1020-8.
15. Ridker PM, Danielson E, Fonseca F, Genest J, Gotto AM, Kastelein JJ, et al. Rosuvastatin to prevent vascular events in men and women with elevated c-reactive protein. N Engl J Med 2008;359:2195-207.