Ovarian stimulation in obese and non-obese polycystic ovary syndrome using a low-dose step-up regimen with two different starting doses of recombinant follicle-stimulating hormone

Journal of International Medical Research

Volumn 36, Issue 6, 2008, Pages 1197-1204

  Yildizhan, Recep ^a   Adali, E ^a   Kolusari, Ali ^a   Kurdoglu, M ^a   Yildizhan, Begum ^b   Sahin, H G ^a   Kamaci, M ^a  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY   (Turkey)

Author keywords

Low dose step up regimen; Obesity; Ovulation induction; Polycystic ovary syndrome; Recombinant follicle stimulating hormone

Indexed keywords

CHORIONIC GONADOTROPIN; PRASTERONE SULFATE; RECOMBINANT FOLLITROPIN; TESTOSTERONE; FOLLITROPIN; LUTEINIZING HORMONE; PRASTERONE; RECOMBINANT PROTEIN;

ADULT; ARTICLE; BODY MASS; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FEMALE INFERTILITY; HUMAN; INSULIN RESISTANCE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; OBESITY; OVARY CYCLE; OVARY FOLLICLE DEVELOPMENT; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; WAIST HIP RATIO; BLOOD; DOSE RESPONSE; DRUG EFFECT; ECHOGRAPHY; METHODOLOGY; OVARY; OVARY FOLLICLE; TREATMENT OUTCOME;

ADULT; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLICLE STIMULATING HORMONE, HUMAN; HUMANS; INFERTILITY, FEMALE; LUTEINIZING HORMONE; OBESITY; OVARIAN FOLLICLE; OVARY; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; RECOMBINANT PROTEINS; TESTOSTERONE; TREATMENT OUTCOME;

EID: 59649090725     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323000803600605     Document Type: Article

References (26)

1. Franks S. Polycustic ovary syndrome. N Engl J Med 1995; 333: 853-861.
2. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19-25.
3. Ferrannini E, Natali A, Bell P, et al: Insulin rsistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 1997; 100: 1166-1173.
4. Dale PO, Tanbo T, Vaaler S, et al: Body weight, hyperinsulinemia, and ganadotropin levels in the polycystic ovarian syndrome: evidence of two distinct popilations. Fertil Steril 1992; 58: 487-491.
5. Pasquali R, Gambineri A, Pagotto U. The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG 2006; 113: 1148-1159.
6. Adams J, Polson DW, Franks S: Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J (Clin Res Ed) 1986; 293: 355-359.
7. Hart R, Norman R: Polycystic ovarian syndrome - prognosis and outsomes. Best Pract Res Clin Obstet Gynaecol 2006; 5: 751-778.
8. Balen A: Ovulation induction. Curr Obstet Gynaecol 2004; 14: 261-268.
9. Messinis IE: Ovulation induction: a mini review. Hum Reprod 2005; 20: 2688-2697.
10. Guidelines of the Turkish Social Insurance Institution. 2007 Yιlι Sosyal Güvenlik Kurumu Uygulama Tebliǧi (SUT). Ankara: Turkish Society of Reproductive Medicine, 2007 (available at http://www.tsrm.org.tr/konu/dosyalar/yonetmelikler/ 2007.yili.ButceveUygulama.pdf).
11. Ferriman D, Gallwey JD: Clinical assessment of body hair growth in women. J Clin Endocrinal Metab 1961; 21: 1440-1447.
12. Matthews DR, Hosker JP, Rudenski AS, et al: Homeostasis model assessment: insulin resistance and β-cell function fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
13. Pasquali R, Patton L, Gambineri A: Obesity and infertility. Curr Opin Endocrinol Diabetes Obes 2007; 14: 482-487.
14. Dunalf A, Segal KR, Futterweit W, et al: Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989; 38: 1165-1174.
15. Imani B, Eijkemans MJ, te Velde ER, et al: Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab 1998; 83: 2361-2365.
16. Utsunomiya T, Toniguchi I, Sadanaga A, et al: Insulin resistance in non-obese patients with polycystic ovary syndrome. Jpn J Fertil Steri 1993; 38: 77-81
17. The Committee for Reproductive and Endocrine in Japan Society of Obstetrics and Gynecology: Annual report (1991-1992) for the determination of diagnostic criteria for polycystic ovary syndrome. Acta Obstet Gynaecol Japonica 1993; 45: 1359-1367 [in Japanese].
18. Franks S, White D: Low-dose gonadotropin treatment in polycystic ovary syndrome: the step-up protocol. In: Ovulation Induction (Tarlatzis B, ed). Paris: Elsevier, 2002; pp 98-107.
19. Hamilton-Fairley D, Kiddy D, Watson H, et al: Low-dose gonadotropin therapy for induction of ovulation in 100 women with polycystic ovary syndrome. Hum Reprod 1991; 6: 1095-1099.
20. Balen AH, Jacobs HS: Anovulatory infertility ans ovulation induction. In: Infertility in Practice (Balen AH, Jacobs HS, eds). London: Churchill Livingstone, 1997; pp 131-180.
21. Baird DT: Use of gonadotropins to induce ovulation in polycystic ovary syndrome. In: The Ovary. Regulation, Dysfunction and Treatment (M Filicori, C Flamigni, eds). Amsterdam: Elsevier Science, 1996; pp 391-401.
22. Gleicher N, Oleske DM, Tur-Kaspa I, et al: Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins. N Engl J Med 2000; 343: 2-7.
23. Homburg R: The management of infertility associated with polycystic ovary syndrome. Reprod Biol Endocrinol 2003; 1: 109.
24. White DM, Polson DW, Kiddy D, et al: Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. J Clin Endocrinol Metab 1996; 81: 3821-3824.
25. Shoham Z, Patel A, Jacobs HS: Polycystic ovary syndrome: safety and effectiveness of stepwise and low-dose administration of purified follicle stimulating hormone. Fertil Steril 1991; 55: 1051-1056.
26. ®). Hum Reprod 1999; 14: 2969-2973.