Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats

Critical Care Medicine

Volumn 37, Issue 1, 2009, Pages 263-269

  Tortorici, Michael A ^a   Mu, Ying ^a   Kochanek, Patrick M ^b,c   Xie, Wen ^a   Poloyac, Samuel M ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Cytochrome P450; Heart arrest; Interleukin 6; Metabolism; Pharmacology; Pregnane X receptor

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 3A2; INTERLEUKIN 6; LUCIFERASE; MESSENGER RNA; PREGNANE X RECEPTOR; CYP3A2 PROTEIN, RAT; DRUG; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COOLING; DOWN REGULATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; GENE; HEART ARREST; INDUCED HYPOTHERMIA; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; TRANSCRIPTION REGULATION; WARMING; ANIMAL; CRYOANESTHESIA; METABOLISM; PHYSIOLOGY;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2E1; HEART ARREST; HYPOTHERMIA, INDUCED; INTERLEUKIN-6; MALE; MEMBRANE PROTEINS; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 59649090365     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181931ed3     Document Type: Article

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