Identification of N-methyl-D-aspartate receptor subunit in human periodontal ligament fibroblasts: Potential role in regulating differentiation

Journal of Periodontology

Volumn 80, Issue 2, 2009, Pages 338-346

  Yu, Ji Hee ^a   Lee, Seung Pyo ^a   Kim, Tae Il ^a   Jang, Jun Hyeog ^b  

^a Seoul National University   (South Korea)

^b Inha University School of Medicine   (South Korea)

Author keywords

Alkaline phosphatase; Cell differentiation; Cell proliferation; Periodontal ligament; Receptors, N methyl D aspartate

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR1 NMDA RECEPTOR; NR2B NMDA RECEPTOR; NR2D NMDA RECEPTOR; PROTEIN SUBUNIT;

ARTICLE; BIOSYNTHESIS; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; FIBROBLAST; HUMAN; PERIODONTAL LIGAMENT; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FIBROBLASTS; HUMANS; PERIODONTAL LIGAMENT; PROTEIN SUBUNITS; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 59649086212     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.080407     Document Type: Article

References (44)

1. Gould TR, Melcher AH, Brunette DM. Migration and division of progenitor cell populations in periodontal ligament after wounding. J Periodontal Res 1980;15:20-42.
2. McCulloch CA, Melcher AH. Cell density and cell generation in the periodontal ligament of mice. Am J Anat 1983;167:43-58.
3. McCulloch CA, Bordin S. Role of fibroblast subpopulations in periodontal physiology and pathology. J Periodontal Res 1991;26:144-154.
4. Isaka J, Ohazama A, Kobayashi M, et al. Participation of periodontal ligament cells with regeneration of alveolar bone. J Periodontol 2001;72:314-323.
5. Lekic P, Rojas J, Birek C, Tenenbaum H, McCulloch CA. Phenotypic comparison of periodontal ligament cells in vivo and in vitro. J Periodontal Res 2001;36:71-79.
6. Murakami Y, Kojima T, Nagasawa T, Kobayashi H, Ishikawa I. Novel isolation of alkaline phosphatase-positive subpopulation from periodontal ligament fibroblasts. J Periodontol 2003;74:780-786.
7. Seo BM, Miura M, Gronthos S, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004;364:149-155.
8. Okubo K, Kobayashi M, Takiguchi T, et al. Participation of endogenous IGF-I and TGF-beta 1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells. J Periodontal Res 2003;38:1-9.
9. Kobayashi M, Takiguchi T, Suzuki R, et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic differentiation in cells isolated from human periodontal ligament. J Dent Res 1999;78:1624-1633.
10. Chenu C. Glutamatergic innervation in bone. Microsc Res Tech 2002;58:70-76.
11. Skerry TM, Genever PG. Glutamate signaling in nonneuronal tissues. Trends Pharmacol Sci 2001;22:174-181.
12. Hollmann M, Heinemann S. Cloned glutamate receptors. Annu Rev Neurosci 1994;17:31-108.
13. Hinoi E, Fujimori S, Takemori A, Kurabayashi H, Nakamura Y, Yoneda Y. Demonstration of expression of mRNA for particular AMPA and kainate receptor subunits in immature and mature cultured rat calvarial osteoblasts. Brain Res 2002;943:112-116.
14. Hinoi E, Takarada T, Yoneda Y. Glutamate signaling system in bone. J Pharmacol Sci 2004;94:215-220.
15. Patton AJ, Genever PG, Birch MA, Suva LJ, Skerry TM. Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone. Bone 1998;22:645-649.
16. Chenu C, Serre CM, Raynal C, Burt-Pichat B, Delmas PD. Glutamate receptors are expressed by bone cells and are involved in bone resorption. Bone 1998;22:295-299.
17. Skerry TM, Taylor AF. Glutamate signaling in bone. Curr Pharm Des 2001;7:737-750.
18. Mason DJ, Suva LJ, Genever PG, et al. Mechanically regulated expression of a neural glutamate transporter in bone: A role for excitatory amino acids as osteotropic agents? Bone 1997;20:199-205.
19. Mayer ML, Westbrook GL. The physiology of excitatory amino acids in vertebrate central nervous system. Prog Neurobiol 1987;28:197-276.
20. Gnegy ME. Ca2+/calmodulin signaling in NMDA-induced synaptic plasticity. Crit Rev Neurobiol 2000;14:91-129.
21. Hinoi E, Fujimori S, Yoneda Y. Modulation of cellular differentiation by N-methyl-d-aspartate receptors in osteoblasts. FASEB J 2003;17:1532-1534.
22. Morhenn VB, Waleh NS, Mansbridge JN, et al. Evidence for an NMDA receptor subunit in human keratinocytes and rat cardiocytes. Eur J Pharmacol 1994;268:409-414.
23. Inagaki N, Kuromi H, Gonoi T, et al. Expression and role of ionotropic glutamate receptors in pancreatic islet cells. FASEB J 1995;9:686-691.
24. Miglio G, Varsaldi F, Lombardi G. Human T lymphocytes express N-methyl-d-aspartate receptors functionally active in controlling T cell activation. Biochem Biophys Res Commun 2005;338:1875-1883.
25. Otsuka E, Yamaguchi A, Hirose S, Hagiwara H. Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid. Am J Physiol 1999;277:C132-C138.
26. Park EH, Kim DS. A procedure for staining cartilage and bone of whole vertebrate larvae while rendering all other tissues transparent. Stain Technol 1984;59:269-272.
27. Taylor AF. Osteoblastic glutamate receptor function regulates bone formation and resorption. J Musculoskelet Neuronal Interact 2002;2:285-290.
28. Taylor AF. Functional osteoblastic ionotropic glutamate receptors are a prerequisite for bone formation. J Musculoskelet Neuronal Interact 2002;2:415-422.
29. Peet NM, Grabowski PS, Laketic-Ljubojevic I, Skerry TM. The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation. FASEB J 1999;13:2179-2185.
30. Breivik T, Gundersen Y, Osmundsen H, Opstad PK, Fonnum F. Chronic treatment with the glutamate receptor antagonist MK-801 alters periodontal disease susceptibility. J Periodontal Res 2005;40:28-35.
31. Chazot PL, Stephenson FA. Molecular dissection of native mammalian forebrain NMDA receptors containing the NR1 C2 exon: Direct demonstration of NMDA receptors comprising NR1, NR2A, and NR2B subunits within the same complex. J Neurochem 1997;69:2138-2144.
32. Plant T, Schirra C, Garaschuk O, Rossier J, Konnerth A. Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain. J Physiol 1997;499:47-63.
33. Dunah AW, Yasuda RP, Wolfe BB. Developmental regulation of tyrosine phosphorylation of the NR2D NMDA glutamate receptor subunit in rat central nervous system. J Neurochem 1998;71:1926-1934.
34. Itzstein C, Cheynel H, Burt-Pichat B, et al. Molecular identification of NMDA glutamate receptors expressed in bone cells. J Cell Biochem 2001;82:134-144.
35. Hinoi E, Fujimori S, Nakamura Y, Yoneda Y. Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts. Biochem Biophys Res Commun 2001;281:341-346.
36. Gu Y, Publicover SJ. Expression of functional metabotropic glutamate receptors in primary cultured rat osteoblasts. Cross-talk with N-methyl-d-aspartate receptors. J Biol Chem 2000;275:34252-34259.
37. Laketić-Ljubojević I, Suva LJ, Maathuis FJ, Sanders D, Skerry TM. Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells. Bone 1999;25:631-637.
38. Mukai M, Yoshimine Y, Akamine A, Maeda K. Bone-like nodules formed in vitro by rat periodontal ligament cells. Cell Tissue Res 1993;271:453-460.
39. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 1997;89:747-754.
40. Komori T, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997;89:755-764.
41. Harada H, Tagashira S, Fujiwara M, et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem 1999;274:6972-6978.
42. Spencer GJ, McGrath CJ, Genever PG. Current perspectives on NMDA-type glutamate signalling in bone. Int J Biochem Cell Biol 2007;39:1089-1104.
43. Yoneda Y, Kuramoto N, Kitayama T, Hinoi E. Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain. Prog Neurobiol 2001;63:697-719.
44. Sabatakos G, Sims NA, Chen J, et al. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med 2000;6:985-990.