Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo

Journal of Periodontology

Volumn 80, Issue 2, 2009, Pages 317-323

  Shimada, Yasuko ^a   Tai, Hideaki ^a   Tanaka, Aya ^a   Ikezawa Suzuki, Ikuyo ^a   Takagi, Keiji ^b   Yoshida, Yasuhiro ^c   Yoshie, Hiromasa ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b Suishodo Pharmaceutical   (Japan)

^c Pias Group Central R and D Laboratory   (Japan)

Author keywords

Ascorbic acid; Gingiva; Hyperpigmentation; Melanin

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; ASCORBIC ACID 2 O GLUCOSIDE; ASCORBIC ACID 2-O-GLUCOSIDE; DRUG DERIVATIVE; MELANIN; MONOPHENOL MONOOXYGENASE;

ADULT; ANIMAL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; FEMALE; GEL; GINGIVA DISEASE; HUMAN; MALE; MELANOSIS; MOUSE; RANDOMIZED CONTROLLED TRIAL; SKIN PIGMENTATION; SPECTROPHOTOMETRY; TUMOR CELL LINE;

ADULT; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELL LINE, TUMOR; DOUBLE-BLIND METHOD; FEMALE; GELS; GINGIVAL DISEASES; HUMANS; MALE; MELANINS; MELANOSIS; MICE; MONOPHENOL MONOOXYGENASE; SKIN PIGMENTATION; SPECTROPHOTOMETRY;

EID: 59649083257     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.080409     Document Type: Article

References (26)

1. Hedin CA, Larsson A. The ultrastructure of the gingival epithelium in smokers' melanosis. J Periodontal Res 1984;19:177-190.
2. Halaban R, Cheng E, Svedine S, Aron R, Hebert DN. Proper folding and endoplasmic reticulumto golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine. J Biol Chem 2001;276:11933-11938.
3. Bergamaschi O, Kon S, Doine AI, Ruben MP. Melanin repigmentation after gingivectomy: A 5-year clinical and transmission electronmicroscopic study in humans. Int J Periodontics Restorative Dent 1993;13:85-92.
4. Tamizi M, Taheri M. Treatment of severe physiologic gingival pigmentation with free gingival autograft. Quintessence Int 1996;27:555-558.
5. Gnanasekhar JD, al-Duwairi YS. Electrosurgery in dentistry. Quintessence Int 1998;29:649-654.
6. Tal H, Landsberg J, Kozlovsky A. Cryosurgical depigmentation of the gingiva. A case report. J Clin Periodontol 1987;14:614-617.
7. Yeh CJ. Cryosurgical treatment of melanin-pigmented gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:660-663.
8. Hasegawa A, Okagi K. Removing melagenous pigmentation using 90 percent phenol with 95 percent alcohol. Dent Outlook 1973;42:673-676.
9. Bishop K. Treatment of unsightly oral pigmentation: A case report. Dent Update 1994;21:236-237.
10. Atsawasuwan P, Greethong K, Nimmanon V. Treatment of gingival hyperpigmentation for esthetic purposes by Nd:YAG laser: Report of 4 cases. J Periodontol 2000;71:315-321.
11. Yousuf A, Hossain M, Nakamura Y, Yamada Y, Kinoshita J, Matsumoto K. Removal of gingival melanin pigmentation with the semiconductor diode laser: A case report. J Clin Laser Med Surg 2000;18:263-266.
12. 2 laser. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:14-15.
13. 2 laser irradiation. J Clin Laser Med Surg 1992;10:41-46.
14. Englard S, Seifter S. The biochemical functions of ascorbic acid. Annu Rev Nutr 1986;6:365-406.
15. Nomura H, Ishigro T, Morimoto S. Studies on L-ascorbic acid derivatives: 3. Bis(L-ascorbic acid-3,3′) phosphate and L-ascorbic acid 2-phosphate. Chem Pharm Bull (Tokyo) 1969;17:387-393.
16. Yamamoto I, Muto N, Nagata E, Nakamura T, Suzuki Y. Formation of a stable L-ascorbic acid alpha-glucoside by mammalian alpha-glucosidase-catalyzed transglucosylation. Biochim Biophys Acta 1990;1035:44-50.
17. Yamamoto I, Muto N, Murakami K, Suga S, Yamaguchi H. L-ascorbic acid alpha-glucoside formed by regioselective transglucosylation with rat intestinal and rice seed alpha-glucosidases: Its improved stability and structure determination. Chem Pharm Bull (Tokyo) 1990;38:3020-3023.
18. Mandai T, Yoneyama M, Sakai S, Muto N, Yamamoto I. The crystal structure and physicochemical properties of L-ascorbic acid 2-glucoside. Carbohydr Res 1992;232:197-205.
19. Hun CH, Seo KI, Park JY, Lim JG, Eun HC, Park KC. A randomized, double-blind, placebo-controlled trial of Vitamin C iontophoresis in melasma. Dermatology 2003;206:316-320.
20. Matsuda S, Endou G, Motomura Y, Ohto T, Araki H. A critical study of treatment for gingival hyperpigmentation by Er:YAG laser (in Japanese). J Jpn Soc Periodontol 2002;44:82-87.
21. Lerch K. Monophenol monooxygenase from Neurospora crassa. Methods Enzymol 1987;142:165-169.
22. Kameyama K, Sakai C, Kondoh S, et al. Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo. J Am Acad Dermatol 1996;34:29-33.
23. Yoon TJ, Lei TC, Yamaguchi Y, Batzer J, Wolber R, Hearing VJ. Reconstituted 3-dimensional human skin of various ethnic origins as an in vitro model for studies of pigmentation. Anal Biochem 2003;318:260-269.
24. Olivella MS, Lhez L, Pappano NB, Debattista NB. Effects of dimethylformamide and L-menthol permeation enhancers on transdermal delivery of quercetin. Pharm Dev Technol 2007;12:481-484.
25. Horiuchi M, Yamamoto T, Tomofuji T, Ishikawa A, Morita M, Watanabe T. Toothbrushing promotes gingival fibroblast proliferation more effectively than removal of dental plaque. J Clin Periodontol 2002;29:791-795.
26. 2 laser irradiation (in Japanese). Japan J Conserv Dent 1999;42:738-743.