The structure and function of the limbal stem Ceil and the disease states associated with limbal stem cell deficiency

International Ophthalmology Clinics

Volumn 49, Issue 1, 2009, Pages 43-52

  Hatch, Kathryn Masselam ^a   Dana, Reza ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; MITOMYCIN C; PILOCARPINE;

CELL REGENERATION; CLINICAL FEATURE; CORNEA; EPITHELIUM CELL; EYE DISEASE; EYE SURGERY; HUMAN; LENS; LIMBAL STEM CELL DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

CORNEAL DISEASES; EPITHELIUM, CORNEAL; HUMANS; IATROGENIC DISEASE; LIMBUS CORNEAE; STEM CELLS;

EID: 59549090847     PISSN: 00208167     EISSN: None     Source Type: Journal    
DOI: 10.1097/IIO.0b013e3181924e54     Document Type: Review

References (31)

1. Dua H, Saini J, Azuara-Blanco A, et al. Limbal stem cell deficiency: concept, aetiology, clinical presentation, diagnosis and management. Indian J Ophthalmol. 2000;48:83-92.
2. Akpek EK, Ilhan-Sarac O. Cicatrizing conjunctivitis. In: Foster CS, Azar DT, Dholmn CH. The Cornea; Scientific Foundations and Clinical Practice. 4th ed., Philadephia: Lippincott Williams and Wilkins; 2005:483-488.
3. Davanger M, Evensen A. Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature. 1971;229:560-561.
4. Lavker RM, Cotsarelis G, Dong G, et al. Limbal location of corneal epithelial stem cells. In: Cavanagh HD, ed. The Cornea. Transactions of the World Congress on Cornea. III. New York: Raven Press; 1988:23.
5. Kasper M, Moll R, Stosiek P, et al. Pattern of cytokeratin and vimantin expression in human eye. Histochemistry. 1988;89:369-374.
6. Thoft RA, Friend J. The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci. 1983;24:1442-1443.
7. Kruse FE. Stem cells and corneal epithelial regeneration. Eye. 1994;8:170-183.
8. Dua HS, Gomes JAP, Singh A. Corneal epithelial wound healing. Br J Ophthalmol. 1994;78:401-408.
9. Pfister RR. Corneal stem cell disease: concepts, categorization, and treatment by auto and homotransplantation of limbal stem cells. CLAO J. 1994;20:64-72.
10. Schwartz GS, Holland EJ. Classification and staging of ocular surface disease, chapter 147. In: Krachmer JH, Mannis MJ, Holland EJ, eds Cornea; Section 3; Ocular Surface Transplantation. 2nd ed. St. Louis: Mosby; 2004:1785-1797.
11. Holland EJ. Epithelial transplantation for the management of severe ocular surface disease. Tran Am Ophthalmol Soc. 1996;44:677-743.
12. Gipson IK. The epithelial basement membrane zone of the limbus. Eye. 1989;3: 132-140.
13. Huang AJ, Tseng SC. Corneal epithelial wound healing in the absence of limbal epithelium. Invest Ophthalmol Vis Sci. 1991;32:96-105.
14. Egbert PR, Lauber S, Maurice DM. A simple conjunctival biopsy. Am J Ophthalmol. 1977;84:798-801.
15. Kenyon KR, Bulusoglu G, Ziske JD. Clinical pathologic correlations of limbal autograft transplantation. Am J Ophthalmol. 1990;31:1-12.
16. Cursiefen C, Chen L, Saint-Geniez M, etal. Nonvascular VGEF receptor 3 expression by coneal epithelium maintains avascularity and vision. Proc Natl Acad Sci USA. 2006;103:11405-11410. Epub July 18, 2006.
17. Nelson LB, Spaeth GL, Nowinski TS, et al. Aniridia: a review. Surv Ophthalmol. 1984;28:621-642.
18. Tseng SC. Concept and application of limbal stem cells. Eye. 1989;3:141-157.
19. Nishida K, Kinoshita S, Ohashi Y, et al. Ocular surface abnormalities in aniridia. Am J Ophthalmol. 1995;120:368-375.
20. Ramaesh K, Ramaesh T, Dutton G, et al. Evolving concepts on the pathologic mechanisms of aniridia related keratopathy. Int J Biochem Cell Biol. 2005;37: 547-557.
21. Koroma B, Tseng S, Sundin OH. Expression of the Pax6 gene in the anterior segment in human aniridia and Sey mouse model. Invest Ophthalmol Vis Sci. 1997;38:4405.
22. Koroma BM, Yang JM, Sundin OH. The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia. Invest Ophthalmol Vis Sci. 2007;38: 108-120.
23. Holland EJ, Djalilian AR, Schwartz GS. Management of aniridic keratopathy with keratolimbal autograft: a limbal transplant cell technique. Ophthalmology. 2003; 110: 125-130.
24. Kremer I, Rajpal Rk, Rapuano CJ, et al. Results of penetrating keratoplasty in aniridia. Am J Ophthalmol. 1994;29:25-29.
25. Gomes JAP, Eagle RC, Gomes AKGDP, et al. Recurrent keratopathy after penetrating keratoplasty for aniridia. Am J Ophthalmol. 1993;115:317-320.
26. Gomes JA, dos Santos MS, Cunha MC, et al. Amniotic membrane transplantation for partial and total limbal stem cell deficiency to chemical burn. Ophthalmology. 2003; 110: 466-473.
27. Schwartz GS, Holland EJ. Iatrogenic limbal stem cell deficiency. Cornea. 1998;17: 31-37.
28. Schwartz GS, Holland EJ. Iatrogenic limbal stem cell deficiency: when glaucoma management contributes to corneal disease. J Glaucoma. 2001;10:443-445.
29. Espana EM, Grueterich M, Romano AC, et al. Idiopathic limbal stem cell deficiency. Ophthalmology. 2002;109:2004-2010.
30. Stoiber J, Muss WH, Pohla-Gubo G, et al. Histopathology of human corneas after amniotic membrane and limbal stem cell transplantation for severe chemical burn. Cornea. 2002;21:482-489.
31. Tseng SCG, Prabhasawat P, Barton K, et al. Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch Ophthalmol. 1998;116:431-441.