Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes

International Immunology

Volumn 21, Issue 2, 2009, Pages 167-177

  Guimont Desrochers, Fanny ^a   Beauchamp, Claudine ^a   Chabot Roy, Geneviève ^a   Dugas, Véronique ^a   Hillhouse, Erin E ^a   Dusseault, Julie ^a   Langlois, Geneviève ^a   Gautier Ethier, Patrick ^a,b   Darwiche, Jinane ^a,b   Sarfati, Marika ^a,b   Lesage, Sylvie ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

CD172a; DC subsets; T cells

Indexed keywords

CD172A ANTIGEN; CD47 ANTIGEN; CD69 ANTIGEN; LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CD4+ CD8- T LYMPHOCYTE; CELL COUNT; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; DENDRITIC CELL; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMALS; ANTIGENS, CD47; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; DENDRITIC CELLS; MICE; MICE, KNOCKOUT; PHAGOCYTOSIS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IMMUNOLOGIC; SELF TOLERANCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 59549087185     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn135     Document Type: Article

References (56)

1. Siggs, O. M., Makaroff, L. E. and Liston, A. 2006. The why and how of thymocyte negative selection. Curr. Opin. Immunol. 18:175.
2. Yin, X., Chtanova, T., Ladi, E. and Robey, E. A. 2006. Thymocyte motility: Mutants, movies and migration patterns. Curr. Opin. Immunol. 18:191.
3. Pettersen, R. D. 2000. CD47 and death signaling in the immune system. Apoptosis 5:299.
4. Brown, E. J. and Frazier, W. A. 2001. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11:130.
5. van Beek, E. M., Cochrane, F., Barclay, A. N. and van den Berg, T. K. 2005. Signal regulatory proteins in the immune system. J. Immunol. 175:7781.
6. Gardai, S. J., McPhillips, K. A., Frasch, S. C. et al. 2005. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123:321.
7. Fujioka, Y., Matozaki, T., Noguchi, T. et al. 1996. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16:6887.
8. Blazar, B. R., Lindberg, F. P., Ingulli, E. et al. 2001. CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J. Exp. Med. 194:541.
9. Oldenborg, P. A., Zheleznyak, A., Fang, Y. F., Lagenaur, C. F., Gresham, H. D. and Lindberg, F. P. 2000. Role of CD47 as a marker of self on red blood cells. Science 288:2051.
10. Wang, H., Madariaga, M. L., Wang, S., Van Rooijen, N., Oldenborg, P. A. and Yang, Y. G. 2007. Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc. Natl Acad. Sci. USA 104:13744.
11. Kikuchi, Y., Uno, S., Kinoshita, Y. et al. 2005. Apoptosis inducing bivalent single-chain antibody fragments against CD47 showed antitumor potency for multiple myeloma. Leuk. Res. 29:445.
12. Uno, S., Kinoshita, Y., Azuma, Y. et al. 2007. Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia. Oncol. Rep. 17:1189.
13. Mateo, V., Brown, E. J., Biron, G. et al. 2002. Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: Link between phosphatidylserine exposure and cytoskeleton organization. Blood 100:2882.
14. Mateo, V., Lagneaux, L., Bron, D. et al. 1999. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nat. Med. 5:1277.
15. Pettersen, R. D., Hestdal, K., Olafsen, M. K., Lie, S. O. and Lindberg, F. P. 1999. CD47 signals T cell death. J. Immunol. 162:7031.
16. Manna, P. P., Dimitry, J., Oldenborg, P. A. and Frazier, W. A. 2005. CD47 augments Fas/CD95-mediated apoptosis. J. Biol. Chem. 280:29637.
17. Kishimoto, H. and Sprent, J. 2001. A defect in central tolerance in NOD mice. Nat. Immunol. 2:1025.
18. Ticchioni, M., Deckert, M., Mary, F., Bernard, G., Brown, E. J. and Bernard, A. 1997. Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells. J. Immunol. 158:677.
19. Seiffert, M., Brossart, P., Cant, C. et al. 2001. Signal-regulatory protein alpha (SIRPalpha) but not SIRPbeta is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34(+)CD38(-) hematopoietic cells. Blood 97:2741.
20. Piccio, L., Vermi, W., Boles, K. S. et al. 2005. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. Blood 105:2421.
21. Reinhold, M. I., Lindberg, F. P., Kersh, G. J., Allen, P. M. and Brown, E. J. 1997. Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway. J. Exp. Med. 185:1.
22. Waclavicek, M., Majdic, O., Stulnig, T. et al. 1997. T cell stimulation via CD47: Agonistic and antagonistic effects of CD47 monoclonal antibody 1/1A4. J. Immunol. 159:5345.
23. Li, Z., Calzada, M. J., Sipes, J. M. et al. 2002. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. J. Cell Biol. 157:509.
24. Lindberg, F. P., Bullard, D. C., Caver, T. E., Gresham, H. D., Beaudet, A. L. and Brown, E. J. 1996. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 274:795.
25. Van, V. Q., Darwiche, J., Raymond, M. et al. 2008. Cutting edge: CD47 controls the in vivo proliferation and homeostasis of peripheral CD4+ CD25+ Foxp3+ regulatory T cells that express CD103. J. Immunol. 181:5204.
26. Hagnerud, S., Manna, P. P., Cella, M. et al. 2006. Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration. J. Immunol. 176:5772.
27. Van, V. Q., Lesage, S., Bouguermouh, S. et al. 2006. Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs. EMBO J. 25:5560.
28. Akkaraju, S., Ho, W. Y., Leong, D., Canaan, K., Davis, M. M. and Goodnow, C. C. 1997. A range of CD4 T cell tolerance: Partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity 7:255.
29. Lesage, S., Charron, J. and Hugo, P. 2001. Inhibitory effects of T-cell stimulation and co-stimulation observed at high concentrations of plate-bound antibodies. J. Immunol. Methods 255:23.
30. Zuniga-Pflucker, J. C. 2004. T-cell development made simple. Nat. Rev. Immunol. 4:67.
31. Bouguermouh, S., Van, V. Q., Martel, J., Gautier, P., Rubio, M. and Sarfati, M. 2008. CD47 expression on T cell is a self-control negative regulator of type 1 immune response. J. Immunol. 180:8073.
32. Punt, J. A., Osborne, B. A., Takahama, Y., Sharrow, S. O. and Singer, A. 1994. Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179:709.
33. Lesage, S., Charron, J., Winslow, G. and Hugo, P. 1997. Induction of thymocyte deletion by purified single peptide/major histocompatibility complex ligands. J. Immunol. 159:2078.
34. Swat, W., Ignatowicz, L., von Boehmer, H. and Kisielow, P. 1991. Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature 351:150.
35. Santori, F. R. and Vukmanovic, S. 2004. Delineation of signals required for thymocyte positive selection. J. Immunol. 173:5517.
36. Mathis, D. and Benoist, C. 2007. A decade of AIRE. Nat. Rev. Immunol. 7:645.
37. Liston, A., Lesage, S., Wilson, J., Peltonen, L. and Goodnow, C. C. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4:350.
38. Liston, A., Gray, D. H., Lesage, S. et al. 2004. Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J. Exp. Med. 200:1015.
39. Lesage, S., Hartley, S. B., Akkaraju, S., Wilson, J., Townsend, M. and Goodnow, C. C. 2002. Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J. Exp. Med. 196:1175.
40. Liston, A., Lesage, S., Gray, D. H. et al. 2004. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 21:817.
41. Lahoud, M. H., Proietto, A. I., Gartlan, K. H. et al. 2006. Signal regulatory protein molecules are differentially expressed by CD8-dendritic cells. J. Immunol. 177:372.
42. Vremec, D., Pooley, J., Hochrein, H., Wu, L. and Shortman, K. 2000. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J. Immunol. 164:2978.
43. Oldenborg, P. A., Gresham, H. D., Chen, Y., Izui, S. and Lindberg, F. P. 2002. Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Blood 99:3500.
44. Shahinian, A., Pfeffer, K., Lee, K. P. et al. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
45. Fahrer, A. M., Bazan, J. F., Papathanasiou, P., Nelms, K. A. and Goodnow, C. C. 2001. A genomic view of immunology. Nature 409:836.
46. Greenwald, R. J., Freeman, G. J. and Sharpe, A. H. 2005. The B7 family revisited. Annu. Rev. Immunol. 23:515.
47. Liu, Y., O'Connor, M. B., Mandell, K. J. et al. 2004. Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha. J. Immunol. 172:2578.
48. de Vries, H. E., Hendriks, J. J., Honing, H. et al. 2002. Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium. J. Immunol. 168:5832.
49. Liu, Y., Buhring, H. J., Zen, K. et al. 2002. Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration. J. Biol. Chem. 277:10028.
50. Verdrengh, M., Lindberg, F. P., Ryden, C. and Tarkowski, A. 1999. Integrin-associated protein (IAP)-deficient mice are less susceptible to developing Staphylococcus aureus-induced arthritis. Microbes Infect. 1:745.
51. Fukunaga, A., Nagai, H., Noguchi, T. et al. 2004. Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes. J. Immunol. 172:4091.
52. Wu, L. and Liu, Y. J. 2007. Development of dendritic-cell lineages. Immunity 26:741.
53. Donskoy, E. and Goldschneider, I. 2003. Two developmentally distinct populations of dendritic cells inhabit the adult mouse thymus: demonstration by differential importation of hematogenous precursors under steady state conditions. J. Immunol. 170:3514.
54. Shortman, K. and Naik, S. H. 2007. Steady-state and inflammatory dendritic-cell development. Nat. Rev. Immunol. 7:19.
55. Zucchelli, S., Holler, P., Yamagata, T., Roy, M., Benoist, C. and Mathis, D. 2005. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 22:385.
56. Barclay, A. N. and Brown, M. H. 2006. The SIRP family of receptors and immune regulation. Nat. Rev. Immunol. 6:457.