Toxicity studies of cremophor-free paclitaxel solid dispersion formulated by a supercritical antisolvent process

Archives of Pharmacal Research

Volumn 32, Issue 1, 2009, Pages 139-148

  Park, Jae Hyun ^b   Chi, Sang Cheol ^b   Lee, Won Seok ^a   Lee, Won Mo ^a   Koo, Yoon Bon ^a   Yong, Chul Soon ^a   Choi, Han Gon ^a   Woo, Jong Soo ^a  

^a Yeungnam University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

LD50; Nephrotoxicity; Paclitaxel; Solid dispersion; Taxol; Toxicity

Indexed keywords

CREMOPHOR; EXCIPIENT; GLYCEROL; HCO 40; HPMC 2910; HYDROXYPROPYLMETHYLCELLULOSE; PACLITAXEL; POLYOXYL 40 HYDROGENATED CASTOR OIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DOSE RESPONSE; DRUG EFFICACY; DRUG FATALITY; DRUG FORMULATION; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HEMOLYSIS; INJECTION; INSTITUTE FOR CANCER RESEARCH MOUSE; KIDNEY MASS; LD 50; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; POWDER; RAT; SINGLE DRUG DOSE; SOLID DISPERSION POWDER; SUPERCRITICAL ANTISOLVENT PROCESS; SUPERCRITICAL FLUID; TECHNIQUE; TOXICITY TESTING; VISCOSITY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BODY WEIGHT; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCIPIENTS; FEMALE; GLYCEROL; HEMOLYSIS; INJECTIONS, INTRAVENOUS; KIDNEY; LETHAL DOSE 50; MALE; MICE; MICE, INBRED ICR; ORGAN SIZE; PACLITAXEL; POLYETHYLENE GLYCOLS; POWDERS; RATS; RATS, SPRAGUE-DAWLEY; TECHNOLOGY, PHARMACEUTICAL;

EID: 59449099561     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1128-y     Document Type: Article

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