Intrathecal methotrexate-induced acute chorea

Journal of Pediatric Hematology/Oncology

Volumn 31, Issue 1, 2009, Pages 57-58

  Necioǧlu Örken, Dilek ^a,b   Yldrmak, Yldz ^a   Kenangil, Gülay ^a   Kandraloǧlu, Nursu ^a   Forta, Hulki ^a   Çelik, Münevver ^a  

^a SISLI ETFAL TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b NONE   (Turkey)

Author keywords

Acute lymphoblastic leukemia; Chorea; Intrathecal methotrexate; Neurotoxicity

Indexed keywords

ASPARAGINASE; CYTARABINE; DAUNORUBICIN; HALOPERIDOL; METHOTREXATE; PREDNISOLONE; VINCRISTINE; ANTINEOPLASTIC ANTIMETABOLITE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANAMNESIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER REGRESSION; CASE REPORT; CHILD; CHOREA MINOR; CLINICAL FEATURE; FEMALE; HUMAN; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; PRIORITY JOURNAL; ACUTE DISEASE; CHEMICALLY INDUCED DISORDER; CHOREA; INTRASPINAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ACUTE DISEASE; ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHOREA; FEMALE; HUMANS; INJECTIONS, SPINAL; METHOTREXATE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TREATMENT OUTCOME;

EID: 59449096934     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e318190d434     Document Type: Article

References (28)

1. Ulukutlu L, Yildiz I, Uǧur S, et al. Paraplegia after intrathecal administration of methotrexate. Turk J Pediatr. 1983;25:167-174.
2. Back EH. Death after intrathecal methotrexate. Lancet. 1969; 2:1005.
3. Naiman JL, Rupprecht LM, Tanyeri G, et al. Intrathecal methotrexate. Lancet. 1970;1:571.
4. Mott MG, Stevenson P, Woog CD. Methotrexate meningitis. Lancet. 1972;2:656.
5. Duttera MJ, Bleyer WA, Pomeroy TC, et al. Irradiation, methotrexate toxicity, and the treatment of meningeal leukaemia. Lancet. 1973;2:703-707.
6. Geiser CF, Bishop Y, Jaffe N, et al. Adverse effects of intrathecal methotrexate in children with acute leukaemia in remission. Blood. 1975;45:189-195.
7. Kay HE, Knapton PJ, O'Sullivan JP, et al. Severe neurological damage associated with methotrexate therapy. Lancet. 1971; 2:542.
8. Mcintosh S, Aspnes GT. Encephalopathy following CNS prophylaxis in childhood lymphoblastic leukaemia. Pediatrics. 1973;52:612-615.
9. Ilhan I, Cila A, Buyukpamukcu M, et al. Methotrexate-induced leukoencephalopathy. A case report. Turk J Pediatr. 1995;37: 275-278.
10. Walker RW, Allen JC, Rosen G, et al. Transient cerebral dysfunction secondary to high-dose methotrexate. J Clin Oncol. 1986;4:1845-1850.
11. Hahn AF, Feasby TE, Gilbert JJ. Paraparesis following intra-thecal chemotherapy. Neurology. 1983;33:1032-1038.
12. Ferhanoglu B, Ongören S, Ar CM, et al. Intrathecal methotrexate-induced acute cerebellar syndrome. Ann Hematol. 2003;82:241-243.
13. Lo Nigro L, Di Cataldo A, Schiliro G. Acute neurotoxicity in children with B-lineage acute lymphoblastic leukemia (B-ALL) treated with intermediate risk protocols. Med Pediatr Oncol. 2000;35:449-455.
14. Shuper A, Stark B, Kornreich L, et al. Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity. J Child Neurol. 2000;15:573-580.
15. Chessells JM, Cox TC, Kendall B, et al. Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation. Arch Dis Child. 1990;65:416-422.
16. Mahoney DH, Shuster JJ, Nitschke R, et al. Acute neurotoxi-city in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy A Pediatric Oncology Group study. J Clin Oncol. 1998;16:1712-1722.
17. Quin CT, Griener JC, Bottiglieri T, et al. Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J Clin Oncol. 1997;15:2800-2806.
18. Bernini JC, Fort DW, Griener JC, et al. Aminophylline for methotrexate-induced neurotoxicity. Lancet. 1995;345:544-547.
19. Drachtman RA, Cole PD, Golden CB, et al. Dextromethor-phan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol. 2002;19:319-327.
20. Quin CT, Kamen BA. A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities. J Invest Med. 1996;44:522-530.
21. Broxson EH, Stork LC, Allen RH, et al. Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions. Cancer Res. 1989;49:5879-5883.
22. Apetauerova D. Chorea. In: Jones RH, Netter FH, eds. Netter's Neurology. New Jersey: Icon Learning Systems; 2005:455-459.
23. Burt AM. Basal Ganglia and Related Nuclei. Textbook of Neuroanatomy. Philadelphia, WB: Saunders Company; 1993:335-347.
24. Garcia TJ, Lopez AJA, Ferris J, et al. Intrathecal chemotherapy-related myeloencephalopathy in a young child with acute lymphoblastic leukaemia. Pediatr Hematol Oncol. 1995;12: 377-385.
25. Sandoval C, Kutscher M, Jayabose S, et al. Neurotoxicity of intrathecal methotrexate MR Imaging findings. AJNR. 2003;24: 1887-1890.
26. Lee ST, Kim M. Diffusion-weighted MRIs in an acute leukoencephalopathy following intrathecal chemotherapy. Neurology. 2004;62:832-833.
27. Rollins N, Winick N, Bash R, et al. Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome. AJNR. 2004;25:1688-1695.
28. Fisher MJ, Khademian ZP, Simon EM, et al. Diffusion-weighted MR imaging of early methotrexate-related neurotoxicity in children. AJNR. 2005;26:1686-1689.