RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer

Cell Cycle

Volumn 8, Issue 3, 2009, Pages 490-497

  Leontieva, Olga V ^a   Ionov, Yuri ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

5 UTR; Colon cancer; Microsatellite instability; RBM35A; Translation; Tumor suppressor

Indexed keywords

LUCIFERASE; MESSENGER RNA; RNA BINDING MOTIF PROTEIN 35A; RNA BINDING PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MICROARRAY ANALYSIS; MICROSATELLITE INSTABILITY; MOUSE; NONHUMAN; POLYSOME; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REPORTER GENE; RNA TRANSLATION; TUMOR SUPPRESSOR GENE;

EID: 59449096532     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.3.7679     Document Type: Article

References (23)

1. Glisovic T, Bachorik JL, Yong J, Dreyfuss G. RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett 2008; 582:1977-86.
2. Lukong KE, Chang KW, Khandjian EW, Richard S. RNA-binding proteins in human genetic disease. Trends Genet 2008; 24:416-25.
3. Sonenberg N. eIF4E, the mRNA cap-binding protein: from basic discovery to translational research. Biochem Cell Biol 2008; 86:178-83.
4. Mourtada-Maarabouni M, Keen J, Clark J, Cooper CS, Williams GT. Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. Exp Cell Res 2006; 312:1745-52.
5. Ivanov I, Lo KC, Hawthorn L, Cowell JK, Ionov Y. Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells. Oncogene 2007; 26:2873-84.
6. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, et al. Inactivation of the type II TGFbeta receptor in colon cancer cells with microsatellite instability. Science 1995; 268:1336-8.
7. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998; 58:5248-57.
8. Duval A, Reperant M, Hamelin R. Comparative analysis of mutation frequency of coding and non coding short mononucleotide repeats in mismatch repair deficient colorectal cancers. Oncogene 2002; 21:8062-6.
9. Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007; 318:1108-13.
10. Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol 2003; 19:207-35.
11. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003; 31:3406-15.
12. Black JD. Protein kinase C isozymes in colon carcinogenesis: guilt by omission. Gastroenterology 2001; 120:1868-72.
13. Verstovsek G, Byrd A, Frey MR, Petrelli NJ, Black JD. Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. Gastroenterology 1998; 115:75-85.
14. Kozak M. Some thoughts about translational regulation: forward and backward glances. J Cell Biochem 2007; 102:280-90.
15. Tsai NP, Bi J, Wei LN. The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. Embo J 2007; 26:1522-31.
16. Cho PF, Poulin F, Cho-Park YA, Cho-Park IB, Chicoine JD, Lasko P, et al. A new paradigm for translational control: inhibition via 5′-3′ mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell 2005; 12:411-23.
17. De Benedetti A, Graff JR. eIF-4E expression and its role in malignancies and metastases. Oncogene 2004; 23:3189-99.
18. Mamane Y, Petroulakis E, Rong L, Yoshida K, Ler LW, Sonenberg N. eIF4E - from translation to transformation. Oncogene 2004; 23:3172-9.
19. Konicek BW, Dumstorf CA, Graff JR. Targeting the eIF4F translation initiation complex for cancer therapy. Cell Cycle 2008; 7:2466-71.
20. Graff JR, Konicek BW, Carter JH, Marcusson EG. Targeting the eukaryotic translation initiation factor 4E for cancer therapy. Cancer Res 2008; 68:631-4.
21. Lazaris-Karatzas A, Montine KS, Sonenberg N. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 1990; 345:544-7.
22. Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B. Identification and classification of p53-regulated genes. Proc Natl Acad Sci USA 1999; 96:14517-22.
23. Leontieva OV, Black JD. Identification of two distinct pathways of protein kinase Calpha downregulation in intestinal epithelial cells. J Biol Chem 2004; 279:5788-01.