Can in vitro assays substitute for in vivo studies in assessing the pulmonary hazards of fine and nanoscale materials?

Journal of Nanoparticle Research

Volumn 11, Issue 2, 2009, Pages 421-431

  Sayes, Christie M ^a,b   Reed, Kenneth L ^a   Subramoney, Shekhar ^a   Abrams, Lloyd ^a   Warheit, David B ^a  

^a DUPONT COMPANY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Cytotoxicity; EHS; In vitro; In vivo; Nanoparticle toxicity; Nanotechnology risk assessment; Pulmonary toxicity

Indexed keywords

EHS; IN VITRO; IN VIVO; NANOPARTICLE TOXICITY; NANOTECHNOLOGY RISK ASSESSMENT; PULMONARY TOXICITY;

BIOLOGICAL ORGANS; CARBONYLATION; CELL CULTURE; CRYSTALLINE MATERIALS; HAZARDS; IRON OXIDES; MACROPHAGES; NANOPARTICLES; NANOSTRUCTURED MATERIALS; NANOTECHNOLOGY; OPTICAL DEVICES; OXIDES; PATHOLOGY; PLASMA WAVES; RATS; RISK ASSESSMENT; RISK MANAGEMENT; SILICA; TOXICITY; ZINC; ZINC OXIDE;

CYTOTOXICITY;

CARBONYL IRON; MACROPHAGE INFLAMMATORY PROTEIN 2; NANOMATERIAL; NANOPARTICLE; SILICON DIOXIDE; ZINC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; LUNG PARENCHYMA; LUNG TOXICITY; NANOTOXICOLOGY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT;

EID: 59449090838     PISSN: 13880764     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11051-008-9471-3     Document Type: Article

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