Interleukin-1 receptor type 1 is a substrate for γ-secretase- dependent regulated intramembrane proteolysis

Journal of Biological Chemistry

Volumn 284, Issue 3, 2009, Pages 1394-1409

  Elzinga, Baukje M ^a   Twomey, Ciara ^a   Powell, James C ^a   Harte, Frances ^a   McCarthy, Justin V ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; ELECTRIC LOAD MANAGEMENT; ENZYME ACTIVITY; PLANTS (BOTANY); PORT TERMINALS; PROTEINS; SUBSTRATES;

BINDING PARTNERS; C-TERMINAL DOMAINS; CELLULAR PROCESS; CO-IMMUNOPRECIPITATION; CONTROL MECHANISMS; CYTOKINE SECRETIONS; DOMINANT NEGATIVES; ECTODOMAIN; GENETIC STUDIES; INTERLEUKIN-1; INTRACELLULAR DOMAINS; INTRAMEMBRANE PROTEOLYSIS; MEMBRANE PROTEINS; METALLO PROTEASE; PRESENILIN; PRESENILINS; PROTEOLYTIC PROCESSING; SECRETASE; SITE-DIRECTED MUTAGENESIS; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED FACTORS;

CELL MEMBRANES;

GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GLUTAMINE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PRESENILIN 1; PROLINE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; ENZYME ACTIVITY; ENZYME SUBSTRATE; HYDROPHILICITY; IMMUNOPRECIPITATION; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; CYTOKINES; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PRESENILIN-1; PROTEASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, INTERLEUKIN-1 TYPE I; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 59449090187     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803108200     Document Type: Article

References (130)

1. Akira, S., and Takeda, K. (2004) Nat. Rev. Immunol. 4, 499-511
2. Creagh, E. M., and O'Neill, L. A. (2006) Trends Immunol. 8, 352-357
3. Takeda, K., and Akira, S. (2005) Int. Immunol. 17, 1-14
4. Subramaniam, S., Stansberg, C., and Cunningham, C. (2004) Dev. Comp. Immunol. 28, 415-428
5. Inoue, J., Gohda, J., and Akiyama, T. (2007) Adv. Exp. Med. Biol. 597, 72-79
6. Lamothe, B., Besse, A., Campos, A. D., Webster, W. K., Wu, H., and Darnay, B. G. (2007) J. Biol. Chem. 282, 4102-4112
7. Chen, Z. J. (2005) Nat. Cell Biol. 7, 758-765
8. Ea, C. K., Sun, L., Inoue, J., and Chen, Z. J. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 15318-15323
9. Beinke, S., Robinson, M. J., Hugunin, M., and Ley, S. C. (2004) Mol. Cell. Biol. 24, 9658-9667
10. Waterfield, M. R., Zhang, M., Norman, L. P., and Sun, S. C. (2003) Mol. Cell 11, 685-694
11. Colotta, F., Dower, S. K., Sims, J. E., and Mantovani, A. (1994) Immunol. Today 15, 562-566
12. Arend, W. P., Malyak, M., Guthridge, C. J., and Gabay, C. (1998) Annu. Rev. Immunol. 16, 27-55
13. Dower, S. K., Wignall, J. M., Schooley, K., McMahan, C. J., Jackson, J. L., Prickett, K. S., Lupton, S., Cosman, D., and Sims, J. E. (1989) J. Immunol. 142, 4314-4320
14. Geetha, T., Jiang, J., and Wooten, M. W. (2005) Mol. Cell 20, 301-312
15. Brissoni, B., Agostini, L., Kropf, M., Martinon, F., Swoboda, V., Lippens, S., Everett, H., Aebi, N., Janssens, S., Meylan, E., Felberbaum-Corti, M., Hirling, H., Gruenberg, J., Tschopp, J., and Burns, K. (2006) Curr. Biol. 16, 2265-2270
16. Gallis, B., Prickett, K. S., Jackson, J., Slack, J., Schooley, K., Sims, J. E., and Dower, S. K. (1989) J. Immunol. 143, 3235-3240
17. Lichtenthaler, S. F., and Steiner, H. (2007) EMBO Rep. 8, 537-541
18. Urra, S., Escudero, C. A., Ramos, P., Lisbona, F., Allende, E., Covarrubias, P., Parraguez, J. I., Zampieri, N., Chao, M. V., Annaert, W., and Bronfman, F. C. (2007) J. Biol. Chem. 282, 7606-7615
19. O'Neill, L. A., and Bowie, A. G. (2007) Nat. Rev. Immunol. 7, 353-364
20. Reichardt, L. F. (2006) Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 1545-1564
21. Levine, S. J. (2008) J. Biol. Chem. 284, 14177-14181
22. Moss, M. L., and Bartsch, J. W. (2004) Biochemistry 43, 7227-7235
23. Blobel, C. P. (2005) Nat. Rev. Mol. Cell Biol. 6, 32-43
24. Black, R. A., and White, J. M. (1998) Curr. Opin. Cell Biol. 10, 654-659
25. Weskamp, G., Schlondorff, J., Lum, L., Becherer, J. D., Kim, T. W., Saftig, P., Hartmann, D., Murphy, G., and Blobel, C.P. (2004) J. Biol. Chem. 279, 4241-4249
26. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-522
27. Landman, N., and Kim, T. W. (2004) Cytokine Growth Factor Rev. 15, 337-351
28. Six, E., Ndiaye, D., Laabi, Y., Brou, C., Gupta-Rossi, N., Israel, A., and Logeat, F. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 7638-7643
29. Bohm, C., Seibel, N. M., Henkel, B., Steiner, H., Haass, C., and Hampe, W. (2006) J. Biol. Chem. 281, 14547-14553
30. Ehrmann, M., and Clausen, T. (2004) Annu. Rev. Genet. 38, 709-724
31. Wolfe, M. S., and Kopan, R. (2004) Science 305, 1119-1123
32. Kuhn, P. H., Marjaux, E., Imhof, A., De Strooper, B., Haass, C., and Lichtenthaler, S. F. (2007) J. Biol. Chem. 282, 11982-11995
33. Iwatsubo, T. (2004) Curr. Opin. Neurobiol. 14, 379-383
34. Beel, A. J., and Sanders, C. R. (2008) Cell. Mol. Life Sci. 65, 1311-1334
35. Brown, M. S., Ye, J., Rawson, R. B., and Goldstein, J. L. (2000) Cell 100, 391-398
36. Lleo, A. (2008) Curr. Top. Med. Chem. 8, 9-16
37. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
38. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
39. McCarthy, J. V. (2005) Biochem. Soc. Trans. 33, 568-572
40. Sato, T., Diehl, T. S., Narayanan, S., Funamoto, S., Ihara, Y., De Strooper, B., Steiner, H., Haass, C., and Wolfe, M. S. (2007) J. Biol. Chem. 282, 33985-33993
41. Zhou, S., Zhou, H., Walian, P. J., and Jap, B. K. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 7499-7504
42. Chen, F., Hasegawa, H., Schmitt-Ulms, G., Kawarai, T., Bohm, C., Katayama, T., Gu, Y., Sanjo, N., Glista, M., Rogaeva, E., Wakutani, Y., Pardossi-Piquard, R., Ruan, X., Tandon, A., Checler, F., Marambaud, P., Hansen, K., Westaway, D., St George-Hyslop, P., and Fraser, P. (2006) Nature 440, 1208-1212
43. Spasic, D., Raemaekers, T., Dillen, K., Declerck, I., Baert, V., Serneels, L., Fullekrug, J., and Annaert, W. (2007) J. Cell Biol. 176, 629-640
44. De Strooper, B. (2005) Cell 122, 318-320
45. Shah, S., Lee, S. F., Tabuchi, K., Hao, Y. H., Yu, C., LaPlant, Q., Ball, H., Dann, C. E., III, Sudhof, T., and Yu, G. (2005) Cell 122, 435-447
46. Wolfe, M. S. (2006) Biochemistry 45, 7931-7939
47. Martoglio, B., and Golde, T. E. (2003) Hum. Mol. Genet. 12, R201-R206
48. Brunkan, A. L., and Goate, A. M. (2005) J. Neurochem. 93, 769-792
49. Xia, W., and Wolfe, M. S. (2003) J. Cell Sci. 116, 2839-2844
50. Yagi, T., Giallourakis, C., Mohanty, S., Scheidig, C., Shen, J., Zheng, H., Xavier, R. J., and Shaw, A. C. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 979-984
51. Maraver, A., Tadokoro, C. E., Badura, M. L., Shen, J., Serrano, M., and Lafaille, J. J. (2007) Blood 110, 3218-3225
52. Becker-Herman, S., Arie, G., Medvedovsky, H., Kerem, A., and Shachar, I. (2005) Mol. Biol. Cell 16, 5061-5069
53. Walsh, D. M., Fadeeva, J. V., LaVoie, M. J., Paliga, K., Eggert, S., Kimberly, W. T., Wasco, W., and Selkoe, D. J. (2003) Biochemistry 42, 6664-6673
54. Hebert, S. S., Serneels, L., Tolia, A., Craessaerts, K., Derks, C., Filippov, M. A., Muller, U., and De Strooper, B. (2006) EMBO Rep. 7, 739-745
55. Leissring, M. A., Murphy, M. P., Mead, T. R., Akbari, Y., Sugarman, M. C., Jannatipour, M., Anliker, B., Muller, U., Saftig, P., De Strooper, B., Wolfe, M. S., Golde, T. E., and LaFerla, F. M. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 4697-4702
56. Nagano, O., and Saya, H. (2004) Cancer Sci. 95, 930-935
57. Jung, K. M., Tan, S., Landman, N., Petrova, K., Murray, S., Lewis, R., Kim, P. K., Kim, D. S., Ryu, S. H., Chao, M. V., and Kim, T. W. (2003) J. Biol. Chem. 278, 42161-42169
58. Marambaud, P., Shioi, J., Serban, G., Georgakopoulos, A., Sarner, S., Nagy, V., Baki, L., Wen, P., Efthimiopoulos, S., Shao, Z., Wisniewski, T., and Robakis, N. K. (2002) EMBO J. 21, 1948-1956
59. Schneider, I., Reverse, D., Dewachter, I., Ris, L., Caluwaerts, N., Kuiperi, C., Gilis, M., Geerts, H., Kretzschmar, H., Godaux, E., Moechars, D., Van Leuven, F., and Herms, J. (2001) J. Biol. Chem. 276, 11539-11544
60. Esselens, C., Oorschot, V., Baert, V., Raemaekers, T., Spittaels, K., Serneels, L., Zheng, H., Saftig, P., De Strooper, B., Klumperman, J., and Annaert, W. (2004) J. Cell Biol. 166, 1041-1054
61. Wilson, C. A., Murphy, D. D., Giasson, B. I., Zhang, B., Trojanowski, J. Q., and Lee, V. M. (2004) J. Cell Biol. 165, 335-346
62. Serban, G., Kouchi, Z., Baki, L., Georgakopoulos, A., Litterst, C. M., Shioi, J., and Robakis, N. K. (2005) J. Biol. Chem. 280, 36007-36012
63. Tournoy, J., Bossuyt, X., Snellinx, A., Regent, M., Garmyn, M., Serneels, L., Saftig, P., Craessaerts, K., De Strooper, B., and Hartmann, D. (2004) Hum. Mol. Genet. 13, 1321-1331
64. Kim, M. Y., Park, J. H., Choi, E. J., and Park, H. S. (2005) Biochem. Biophys. Res. Commun. 332, 609-613
65. Kim, J. W., Chang, T. S., Lee, J. E., Huh, S. H., Yeon, S. W., Yang, W. S., Joe, C. O., Mook-Jung, I., Tanzi, R. E., Kim, T. W., and Choi, E. J. (2001) J. Cell Biol. 153, 457-463
66. Twomey, C., and McCarthy, J. V. (2006) FEBS Lett. 580, 4015-4020
67. Muzio, M., Ni, J., Feng, P., and Dixit, V. M. (1997) Science 278, 1612-1615
68. Zhao, G., Mao, G., Tan, J., Dong, Y., Cui, M. Z., Kim, S. H., and Xu, X. (2004) J. Biol. Chem. 279, 50647-50650
69. Morohashi, Y., Kan, T., Tominari, Y., Fuwa, H., Okamura, Y., Watanabe, N., Sato, C., Natsugari, H., Fukuyama, T., Iwatsubo, T., and Tomita, T. (2006) J. Biol. Chem. 281, 14670-14676
70. Kirschenbaum, F., Hsu, S. C., Cordell, B., and McCarthy, J. V. (2001) J. Biol. Chem. 276, 7366-7375
71. Seiffert, D., Bradley, J. D., Rominger, C. M., Rominger, D. H., Yang, F., Meredith, J. E., Jr., Wang, Q., Roach, A. H., Thompson, L. A., Spitz, S. M., Higaki, J. N., Prakash, S. R., Combs, A. P., Copeland, R. A., Arneric, S. P., Hartig, P. R., Robertson, D. W., Cordell, B., Stern, A. M., Olson, R. E., and Zaczek, R. (2000) J. Biol. Chem. 275, 34086-34091
72. Watters, T. M., Kenny, E. F., and O'Neill, L. A. (2007) Immunol. Cell Biol. 85, 411-419
73. Dunne, A., and O'Neill, L. A. (2005) FEBS Lett. 579, 3330-3335
74. Khursigara, G., Orlinick, J. R., and Chao, M. V. (1999) J. Biol. Chem. 274, 2597-2600
75. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., and Goeddel, D. V. (1996) Nature 383, 443-446
76. Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E., Yamamoto, T., and Inoue, J. (1996) J. Biol. Chem. 271, 28745-28748
77. Wooten, M. W., Seibenhener, M. L., Mamidipudi, V., Diaz-Meco, M. T., Barker, P. A., and Moscat, J. (2001) J. Biol. Chem. 276, 7709-7712
78. Wooten, M. W., Geetha, T., Seibenhener, M. L., Babu, J. R., Diaz-Meco, M. T., and Moscat, J. (2005) J. Biol. Chem. 280, 35625-35629
79. Lu, C., Wang, A., Dorsch, M., Tian, J., Nagashima, K., Coyle, A. J., Jaffee, B., Ocain, T. D., and Xu, Y. (2005) J. Biol. Chem. 280, 16278-16283
80. Pullen, S. S., Miller, H. G., Everdeen, D. S., Dang, T. T., Crute, J. J., and Kehry, M. R. (1998) Biochemistry 37, 11836-11845
81. Ye, H., Arron, J. R., Lamothe, B., Cirilli, M., Kobayashi, T., Shevde, N. K., Segal, D., Dzivenu, O. K., Vologodskaia, M., Yim, M., Du, K., Singh, S., Pike, J. W., Darnay, B. G., Choi, Y., and Wu, H. (2002) Nature 418, 443-447
82. Darnay, B. G., Ni, J., Moore, P. A., and Aggarwal, B. B. (1999) J. Biol. Chem. 274, 7724-7731
83. Mansell, A., Brint, E., Gould, J. A., O'Neill, L. A., and Hertzog, P. J. (2004) J. Biol. Chem. 279, 37227-37230
84. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
85. Thinakaran, G., Harris, C. L., Ratovitski, T., Davenport, F., Slunt, H. H., Price, D. L., Borchelt, D. R., and Sisodia, S. S. (1997) J. Biol. Chem. 272, 28415-28422
86. Ratovitski, T., Slunt, H. H., Thinakaran, G., Price, D. L., Sisodia, S. S., and Borchelt, D. R. (1997) J. Biol. Chem. 272, 24536-24541
87. Podlisny, M. B., Citron, M., Amarante, P., Sherrington, R., Xia, W., Zhang, J., Diehl, T., Levesque, G., Fraser, P., Haass, C., Koo, E. H., Seubert, P., St George-Hyslop, P., Teplow, D. B., and Selkoe, D. J. (1997) Neurobiol. Dis. 3, 325-337
88. Kirschenbaum, F., Hsu, S. C., Cordell, B., and McCarthy, J. V. (2001) J. Biol. Chem. 276, 30701-30707
89. Pineda, G., Ea, C. K., and Chen, Z. J. (2007) Adv. Exp. Med. Biol. 597, 80-92
90. Kanning, K. C., Hudson, M., Amieux, P. S., Wiley, J. C., Bothwell, M., and Schecterson, L. C. (2003) J. Neurosci. 23, 5425-5436
91. Slack, J., McMahan, C. J., Waugh, S., Schooley, K., Spriggs, M. K., Sims, J. E., and Dower, S. K. (1993) J. Biol. Chem. 268, 2513-2524
92. Fernandez-Botran, R., Crespo, F. A., and Sun, X. (2002) Expert Opin. Biol. Ther. 2, 585- 605
93. Fernandez-Botran, R., Chilton, P. M., and Ma, Y. (1996) Adv. Immunol. 63, 269-336
94. Mantovani, A., Muzio, M., Ghezzi, P., Colotta, C., and Introna, M. (1998) Ann. N. Y. Acad. Sci. 840, 338-351
95. Huovila, A. P., Turner, A. J., Pelto-Huikko, M., Karkkainen, I., and Ortiz, R. M. (2005) Trends Biochem. Sci. 30, 413-422
96. Kheradmand, F., and Werb, Z. (2002) BioEssays 24, 8-12
97. Maretzky, T., Reiss, K., Ludwig, A., Buchholz, J., Scholz, F., Proksch, E., de Strooper, B., Hartmann, D., and Saftig, P. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 9182-9187
98. Brunkan, A. L., Martinez, M., Walker, E. S., and Goate, A. M. (2005) Mol. Cell Neurosci 29, 65-73
99. Underwood, C. K., Reid, K., May, L. M., Bartlett, P. F., and Coulson, E. J. (2008) Mol. Cell. Neurosci. 37, 346-358
100. Repetto, E., Yoon, I. S., Zheng, H., and Kang, D. E. (2007) J. Biol. Chem. 282, 31504-31516
101. Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J., and Kopan, R. (2000) Mol. Cell 5, 197-206
102. Kanayama, A., Seth, R. B., Sun, L., Ea, C. K., Hong, M., Shaito, A., Chiu, Y. H., Deng, L., and Chen, Z. J. (2004) Mol. Cell 15, 535-548
103. Saura, C. A., Choi, S. Y., Beglopoulos, V., Malkani, S., Zhang, D., Shan-karanarayana Rao, B. S., Chattarji, S., Kelleher, R. J., III, Kandel, E. R., Duff, K., Kirkwood, A., and Shen, J. (2004) Neuron 42, 23-36
104. Carey, B. W., Kim, D. Y., and Kovacs, D. M. (2007) Biochem. J. 401, 121-127
105. Keating, S. E., Maloney, G. M., Moran, E. M., and Bowie, A. G. (2007) J. Biol. Chem. 282, 33435-33443
106. Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., and Chen, Z. J. (2000) Cell 103, 351-361
107. Sun, L., Deng, L., Ea, C. K., Xia, Z. P., and Chen, Z. J. (2004) Mol. Cell 14, 289-301
108. Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J., and Chen, Z. J. (2001) Nature 412, 346-351
109. Li, J., Pauley, A. M., Myers, R. L., Shuang, R., Brashler, J. R., Yan, R., Buhl, A. E., Ruble, C., and Gurney, M. E. (2002) J. Neurochem. 82, 1540-1548
110. Liu, Q. A., and Hengartner, M. O. (1999) Ann. N. Y. Acad. Sci. 887, 92-104
111. Chang, L., and Karin, M. (2001) Nature 410, 37-40
112. Nishina, H., Wada, T., and Katada, T. (2004) J. Biochem. (Tokyo) 136, 123-126
113. Parks, A. L., and Curtis, D. (2007) Trends Genet. 23, 140-150
114. Friedmann, E., Hauben, E., Maylandt, K., Schleeger, S., Vreugde, S., Lichtenthaler, S. F., Kuhn, P. H., Stauffer, D., Rovelli, G., and Martoglio, B. (2006) Nat. Cell Biol. 8, 843-848
115. Fanslow, W. C., Sims, J. E., Sassenfeld, H., Morrissey, P. J., Gillis, S., Dower, S. K., and Widmer, M. B. (1990) Science 248, 739-742
116. Nicoletti, F., Di Marco, R., Barcellini, W., Magro, G., Schorlemmer, H. U., Kurrle, R., Lunetta, M., Grasso, S., Zaccone, P., and Meroni, P. (1994) Eur. J. Immunol. 24, 1843-1847
117. Drevlow, B. E., Lovis, R., Haag, M. A., Sinacore, J. M., Jacobs, C., Blosche, C., Landay, A., Moreland, L. W., and Pope, R. M. (1996) Arthritis Rheum. 39, 257-265
118. Dinarello, C. A. (2004) Curr. Opin. Pharmacol. 4, 378-385
119. Ni, C. Y., Murphy, M. P., Golde, T. E., and Carpenter, G. (2001) Science 294, 2179-2181
120. Cowan, J. W., Wang, X., Guan, R., He, K., Jiang, J., Baumann, G., Black, R. A., Wolfe, M. S., and Frank, S. J. (2005) J. Biol. Chem. 280, 19331-19342
121. Akira, S., and Takeda, K. (2004) C. R. Biol. 327, 581-589
122. Li, Q., Harraz, M. M., Zhou, W., Zhang, L. N., Ding, W., Zhang, Y., Eggleston, T., Yeaman, C., Banfi, B., and Engelhardt, J. F. (2006) Mol. Cell. Biol. 26, 140-154
123. Litterst, C., Georgakopoulos, A., Shioi, J., Ghersi, E., Wisniewski, T., Wang, R., Ludwig, A., and Robakis, N. K. (2007) J. Biol. Chem. 282, 16155-16163
124. Vaccari, T., Lu, H., Kanwar, R., Fortini, M. E., and Bilder, D. (2008) J. Cell Biol. 180, 755-762
125. Uemura, K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., and Kinoshita, A. (2007) Neuroscience 145, 5-10
126. Curtis, B. M., Widmer, M. B., de Roos, P., and Qwarnstrom, E. E. (1990) J. Immunol. 144, 1295-1303
127. Akiyama, S., Yonezawa, T., Kudo, T. A., Li, M. G., Wang, H., Ito, M., Yoshioka, K., Ninomiya-Tsuji, J., Matsumoto, K., Kanamaru, R., Tamura, S., and Kobayashi, T. (2004) J. Biol. Chem. 279, 36616-36620
128. Sardi, S. P., Murtie, J., Koirala, S., Patten, B. A., and Corfas, G. (2006) Cell 127, 185-197
129. Pardossi-Piquard, R., Dunys, J., Yu, G., St George-Hyslop, P., Alves da Costa, C., and Checler, F. (2005) Neuron 46, 541-554
130. Alves da Costa, C., Sunyach, C., Pardossi-Piquard, R., Sévalle, J., Vincent, B., Boyer, N., Kawarai, T., Girardot, N., St George-Hyslop, P., and Checler, F. (2006) J. Neurosci. 26, 6377-6385