-
1
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R. T. (2001). Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
2
-
-
33646795891
-
Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
-
Adams, K. E., Medhurst, A. L., Dart, D. A. and Lakin, N. D. (2006). Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene 25, 3894-3904.
-
(2006)
Oncogene
, vol.25
, pp. 3894-3904
-
-
Adams, K.E.1
Medhurst, A.L.2
Dart, D.A.3
Lakin, N.D.4
-
3
-
-
18244385718
-
ATRIP binding to replication protein A- single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
-
Ball, H. L., Myers, J. S. and Cortez, D. (2005). ATRIP binding to replication protein A- single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 16, 2372-2381.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 2372-2381
-
-
Ball, H.L.1
Myers, J.S.2
Cortez, D.3
-
4
-
-
0035927713
-
ATR/ ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
-
Bao, S., Tibbetts, R. S., Brumbaugh, K. M., Fang, Y., Richardson, D. A., Ali, A., Chen, S. M., Abraham, R. T. and Wang, X. F. (2001). ATR/ ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411, 969-974.
-
(2001)
Nature
, vol.411
, pp. 969-974
-
-
Bao, S.1
Tibbetts, R.S.2
Brumbaugh, K.M.3
Fang, Y.4
Richardson, D.A.5
Ali, A.6
Chen, S.M.7
Abraham, R.T.8
Wang, X.F.9
-
5
-
-
22944462083
-
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
-
Bekker-Jensen, S., Lukas, C., Melander, F., Bartek, J. and Lukas, J. (2005). Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J. Cell Biol. 170, 201-211.
-
(2005)
J. Cell Biol
, vol.170
, pp. 201-211
-
-
Bekker-Jensen, S.1
Lukas, C.2
Melander, F.3
Bartek, J.4
Lukas, J.5
-
6
-
-
0037452605
-
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
-
Bermudez, V. P., Lindsey-Boltz, L. A., Cesare, A. J., Maniwa, Y., Griffith, J. D., Hurwitz, J. and Sancar, A. (2003). Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc. Natl. Acad. Sci. USA 100, 1633-1638.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1633-1638
-
-
Bermudez, V.P.1
Lindsey-Boltz, L.A.2
Cesare, A.J.3
Maniwa, Y.4
Griffith, J.D.5
Hurwitz, J.6
Sancar, A.7
-
7
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun, T. S., Pacek, M., Yee, M. C., Walter, J. C. and Cimprich, K. A. (2005). Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 19, 1040-1052.
-
(2005)
Genes Dev
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
8
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
Celeste, A., Fernandez-Capetillo, O., Kruhlak, M. J., Pilch, D. R., Staudt, D. W., Lee, A., Bonner, R. F., Bonner, W. M. and Nussenzweig, A. (2003). Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat. Cell Biol. 5, 675-679.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 675-679
-
-
Celeste, A.1
Fernandez-Capetillo, O.2
Kruhlak, M.J.3
Pilch, D.R.4
Staudt, D.W.5
Lee, A.6
Bonner, R.F.7
Bonner, W.M.8
Nussenzweig, A.9
-
9
-
-
3242879828
-
Chk1 in the DNA damage response: Conserved roles from yeasts to mammals
-
Chen, Y. and Sanchez, Y. (2004). Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst.) 3, 1025-1032.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 1025-1032
-
-
Chen, Y.1
Sanchez, Y.2
-
10
-
-
1942437440
-
Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase
-
Dart, D. A., Adams, K. E., Akerman, I. and Lakin, N. D. (2004). Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase. J. Biol. Chem. 279, 16433-16440.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 16433-16440
-
-
Dart, D.A.1
Adams, K.E.2
Akerman, I.3
Lakin, N.D.4
-
11
-
-
34250705797
-
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
-
Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K. and Karnitz, L. M. (2007). The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 21, 1472-1477.
-
(2007)
Genes Dev
, vol.21
, pp. 1472-1477
-
-
Delacroix, S.1
Wagner, J.M.2
Kobayashi, M.3
Yamamoto, K.4
Karnitz, L.M.5
-
12
-
-
4243156107
-
Biochemical characterization of dna damage checkpoint complexes: Clamp loader and clamp complexes with specificity for 5′ recessed DNA
-
Ellison, V. and Stillman, B. (2003). Biochemical characterization of dna damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5′ recessed DNA. PLoS Biol. 1, E33.
-
(2003)
PLoS Biol
, vol.1
-
-
Ellison, V.1
Stillman, B.2
-
13
-
-
27144491909
-
Nuclear dynamics of PCNA in DNA replication and repair
-
Essers, J., Theil, A. F., Baldeyron, C., van Cappellen, W. A., Houtsmuller, A. B., Kanaar, R. and Vermeulen, W. (2005). Nuclear dynamics of PCNA in DNA replication and repair. Mol. Cell. Biol. 25, 9350-9359.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 9350-9359
-
-
Essers, J.1
Theil, A.F.2
Baldeyron, C.3
van Cappellen, W.A.4
Houtsmuller, A.B.5
Kanaar, R.6
Vermeulen, W.7
-
14
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J. and Smith, G. C. (2004). Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64, 9152-9159.
-
(2004)
Cancer Res
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
Zhao, Y.2
Richardson, C.J.3
Green, S.J.4
Martin, N.M.5
Orr, A.I.6
Reaper, P.M.7
Jackson, S.P.8
Curtin, N.J.9
Smith, G.C.10
-
15
-
-
18744374129
-
Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo
-
Hoogstraten, D., Nigg, A. L., Heath, H., Mullenders, L. H., van Driel, R., Hoeijmakers, J. H., Vermeulen, W. and Houtsmuller, A. B. (2002). Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo. Mol. Cell 10, 1163-1174.
-
(2002)
Mol. Cell
, vol.10
, pp. 1163-1174
-
-
Hoogstraten, D.1
Nigg, A.L.2
Heath, H.3
Mullenders, L.H.4
van Driel, R.5
Hoeijmakers, J.H.6
Vermeulen, W.7
Houtsmuller, A.B.8
-
16
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C., Lukas, J. and Jackson, S. P. (2006). ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8, 37-45.
-
(2006)
Nat. Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
-
17
-
-
0031435461
-
Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry
-
Kalejta, R. F., Shenk, T. and Beavis, A. J. (1997). Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Cytometry 29, 286-291.
-
(1997)
Cytometry
, vol.29
, pp. 286-291
-
-
Kalejta, R.F.1
Shenk, T.2
Beavis, A.J.3
-
18
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan, M. B. and Bartek, J. (2004). Cell-cycle checkpoints and cancer. Nature 432, 316-323.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
19
-
-
0035955398
-
Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
-
Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K. and Sugimoto, K. (2001). Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Science 294, 867-870.
-
(2001)
Science
, vol.294
, pp. 867-870
-
-
Kondo, T.1
Wakayama, T.2
Naiki, T.3
Matsumoto, K.4
Sugimoto, K.5
-
20
-
-
0037289840
-
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
-
Kumagai, A. and Dunphy, W. G. (2003). Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat. Cell Biol. 5, 161-165.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 161-165
-
-
Kumagai, A.1
Dunphy, W.G.2
-
21
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai, A., Lee, J., Yoo, H. Y. and Dunphy, W. G. (2006). TopBP1 activates the ATR-ATRIP complex. Cell 124, 943-955.
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
Dunphy, W.G.4
-
22
-
-
34948889415
-
The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
-
Lee, J., Kumagai, A. and Dunphy, W. G. (2007). The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 282, 28036-28044.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 28036-28044
-
-
Lee, J.1
Kumagai, A.2
Dunphy, W.G.3
-
23
-
-
4544281398
-
Choreography of the DNA damage response; spatiotemporal relationships among checkpoint and repair proteins
-
Lisby, M., Barlow, J. H., Burgess, R. C. and Rothstein, R. (2004). Choreography of the DNA damage response; spatiotemporal relationships among checkpoint and repair proteins. Cell 118, 699-713.
-
(2004)
Cell
, vol.118
, pp. 699-713
-
-
Lisby, M.1
Barlow, J.H.2
Burgess, R.C.3
Rothstein, R.4
-
24
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas, C., Falck, J., Bartkova, J., Bartek, J. and Lukas, J. (2003). Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5, 255-260.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
25
-
-
3342915628
-
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
-
Lukas, C., Melander, F., Stucki, M., Falck, J., Bekker-Jensen, S., Goldberg, M., Lerenthal, Y., Jackson, S. P., Bartek, J. and Lukas, J. (2004a). Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J. 23, 2674-2683.
-
(2004)
EMBO J
, vol.23
, pp. 2674-2683
-
-
Lukas, C.1
Melander, F.2
Stucki, M.3
Falck, J.4
Bekker-Jensen, S.5
Goldberg, M.6
Lerenthal, Y.7
Jackson, S.P.8
Bartek, J.9
Lukas, J.10
-
26
-
-
3242890575
-
Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time
-
Lukas, J., Lukas, C. and Bartek, J. (2004b). Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst.) 3, 997-1007.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 997-1007
-
-
Lukas, J.1
Lukas, C.2
Bartek, J.3
-
27
-
-
2942587456
-
Dynamics of protein binding to telomeres in living cells: Implications for telomere structure and function
-
Mattern, K. A., Swiggers, S. J., Nigg, A. L., Lowenberg, B., Houtsmuller, A. B. and Zijlmans, J. M. (2004). Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function. Mol. Cell. Biol. 24, 5587-5594.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 5587-5594
-
-
Mattern, K.A.1
Swiggers, S.J.2
Nigg, A.L.3
Lowenberg, B.4
Houtsmuller, A.B.5
Zijlmans, J.M.6
-
28
-
-
0036531901
-
A unified view of the DNA-damage checkpoint
-
Melo, J. and Toczyski, D. (2002). A unified view of the DNA-damage checkpoint. Curr. Opin. Cell Biol. 14, 237-245.
-
(2002)
Curr. Opin. Cell Biol
, vol.14
, pp. 237-245
-
-
Melo, J.1
Toczyski, D.2
-
29
-
-
0035498938
-
Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
-
Melo, J. A., Cohen, J. and Toczyski, D. P. (2001). Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 15, 2809-2821.
-
(2001)
Genes Dev
, vol.15
, pp. 2809-2821
-
-
Melo, J.A.1
Cohen, J.2
Toczyski, D.P.3
-
30
-
-
0033756308
-
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis
-
Mendez, J. and Stillman, B. (2000). Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol. 20, 8602-8612.
-
(2000)
Mol. Cell. Biol
, vol.20
, pp. 8602-8612
-
-
Mendez, J.1
Stillman, B.2
-
31
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A. and Goodship, J. A. (2003). A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33, 497-501.
-
(2003)
Nat. Genet
, vol.33
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
32
-
-
34249937178
-
The ATR pathway: Fine-tuning the fork
-
Paulsen, R. D. and Cimprich, K. A. (2007). The ATR pathway: fine-tuning the fork. DNA Repair (Amst.) 6, 953-966.
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 953-966
-
-
Paulsen, R.D.1
Cimprich, K.A.2
-
33
-
-
19444363834
-
53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin
-
Pryde, F., Khalili, S., Robertson, K., Selfridge, J., Ritchie, A. M., Melton, D. W., Jullien, D. and Adachi, Y. (2005). 53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin. J. Cell Sci. 118, 2043-2055.
-
(2005)
J. Cell Sci
, vol.118
, pp. 2043-2055
-
-
Pryde, F.1
Khalili, S.2
Robertson, K.3
Selfridge, J.4
Ritchie, A.M.5
Melton, D.W.6
Jullien, D.7
Adachi, Y.8
-
34
-
-
30944435598
-
Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
-
Smits, V. A., Reaper, P. M. and Jackson, S. P. (2006). Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr. Biol. 16, 150-159.
-
(2006)
Curr. Biol
, vol.16
, pp. 150-159
-
-
Smits, V.A.1
Reaper, P.M.2
Jackson, S.P.3
-
35
-
-
29244434544
-
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
-
Stucki, M., Clapperton, J. A., Mohammad, D., Yaffe, M. B., Smerdon, S. J. and Jackson, S. P. (2005). MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123, 1213-1226.
-
(2005)
Cell
, vol.123
, pp. 1213-1226
-
-
Stucki, M.1
Clapperton, J.A.2
Mohammad, D.3
Yaffe, M.B.4
Smerdon, S.J.5
Jackson, S.P.6
-
36
-
-
0141619287
-
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
-
Veuger, S. J., Curtin, N. J., Richardson, C. J., Smith, G. C. and Durkacz, B. W. (2003). Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 63, 6008-6015.
-
(2003)
Cancer Res
, vol.63
, pp. 6008-6015
-
-
Veuger, S.J.1
Curtin, N.J.2
Richardson, C.J.3
Smith, G.C.4
Durkacz, B.W.5
-
37
-
-
33746408535
-
Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
-
Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K. E., Hittelman, W. N., Elledge, S. J. and Li, L. (2006). Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol. Cell 23, 331-341.
-
(2006)
Mol. Cell
, vol.23
, pp. 331-341
-
-
Wang, X.1
Zou, L.2
Lu, T.3
Bao, S.4
Hurov, K.E.5
Hittelman, W.N.6
Elledge, S.J.7
Li, L.8
-
38
-
-
0037178814
-
The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint
-
You, Z., Kong, L. and Newport, J. (2002). The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. J. Biol. Chem. 277, 27088-27093.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 27088-27093
-
-
You, Z.1
Kong, L.2
Newport, J.3
-
39
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou, L. and Elledge, S. J. (2003). Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
40
-
-
0037080675
-
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
-
Zou, L., Cortez, D. and Elledge, S. J. (2002). Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16, 198-208.
-
(2002)
Genes Dev
, vol.16
, pp. 198-208
-
-
Zou, L.1
Cortez, D.2
Elledge, S.J.3
-
41
-
-
0345564858
-
Replication protein A-mediated recruitment and activation of Rad17 complexes
-
Zou, L., Liu, D. and Elledge, S. J. (2003). Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc. Natl. Acad. Sci. USA 100, 13827-13832.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 13827-13832
-
-
Zou, L.1
Liu, D.2
Elledge, S.J.3
|