Animal models in biomedical research: Ethics, challenges, and opportunities

Principles of Molecular Medicine

Volumn , Issue , 2006, Pages 53-60

  Williams, Robert W ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Animal model; biomedical research; humanizing mice; inbred; molecular medicine

Indexed keywords

EID: 59349098522     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-59259-963-9_8     Document Type: Chapter

References (22)

1. Biobank. University of Manchester. Manchester, England (www.biobank. ac.uk). Accessed May 11, 2005.
2. Brenner S. Nature's gift to science. Nobel Lecture 2002; pp. 274-282. (www.nobel.se/medicine/laureates/2002/brenner-lecture.pdf). Accessed Jan. 14, 2006.
3. Chesler EJ,Wang J,Williams RW, Manly KF. Web QTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nat Neurosci 2004; 7:485-486.
4. Crick F, Koch C. The unconscious homunculus. In: Metzinger T, ed. The Neuronal Correlates of Consciousness. Cambridge, MA: MIT Press, 2000; pp. 103-110.
5. deCODE Genetics. Reykjavik, Iceland (www.decodegenetics.com). Accessed May 11, 2005.
6. Gudrais E. Chimpanzees and the law. Harv Mag 2003;105:21, 22.
7. Kuperwasser C, Chavarria T, Wu M, et al. Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci USA 2004;101:4966-4971.
8. Leaf C. Why we're losing the war on cancer. Fortune 2004;149:76-97.
9. Little CC. The role of heredity in determining the incidence and growth of cancer. Am J Cancer 1931;15:2780-2789.
10. Lusis AJ, West D, Davis C. Animal models of complex genetic disease. In: King RA, Rotter JI, Motulsky AG, eds. The Genetic Basis of Common Disease, 2nd ed. New York: Oxford University Press, 2002; pp. 65-86.
11. Nagy A, Gertsenstein M, Vintersten K, Behringer R. Manipulating the Mouse Embryo: A Laboratory Manual, 3rd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2003.
12. National Academy Press: Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 1996.
13. Paired Box Gene 6; PAX6. OMIM. Johns Hopkins University. Baltimore, Maryland (www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607108). Accessed May 11, 2005.
14. Pauling L, Itano HA. Sickle cell anemia: a molecular disease. Science 1949;110:543-548.
15. Quiring R, Walldorf U, Kloter U, Gerhing WJ. Homology of the eyeless gene in Drosophila to the small eye gene in mice and anirdia in humans. Science 1994;2655:785-789.
16. Rader K. The mouse's tale: standardized animals in the culture and practice of technoscience. Cabinet Mag 2001;4. www.cabinet magazine.org/issues/ 4/themousestale.php). Accessed Jan. 14, 2006.
17. Ryan TM, Townes TM, Reilly MP, et al. Human sickle hemoglobin in transgenic mice. Science 1990;247:566-568.
18. Silver LM. Mouse Genetics. Concepts and Applications. New York: Oxford University Press, 1995.
19. Threadgill DW, Hunter KW,Williams RW. Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mamm Genome 2002;13:175-178.
20. Vogel G. Scientists dream of 1001 complex mice. Science 2003;301: 456, 457.
21. Williams RJ. Biochemical Individuality. New York: John Wiley & Sons, 1998.
22. Zerhouni E. The NIH roadmap. Science 2003;302:63.