Expression of Extracellular Matrix Genes During Myocardial Recovery From Heart Failure After Left Ventricular Assist Device Support

Journal of Heart and Lung Transplantation

Volumn 28, Issue 2, 2009, Pages 117-122

  Felkin, Leanne E ^a   Lara Pezzi, Enrique ^a,b   George, Robert ^c   Yacoub, Magdi H ^a   Birks, Emma J ^a,c   Barton, Paul J R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^c HAREFIELD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BISOPROLOL; CARVEDILOL; CLENBUTEROL; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; COLLAGEN TYPE 3; COLLAGEN TYPE 3 ALPHA 1; COLLAGENASE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LISINOPRIL; LOSARTAN; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; NEUTROPHIL COLLAGENASE; SPIRONOLACTONE; STROMELYSIN; STROMELYSIN 2; STROMELYSIN 3; THY 1 ANTIGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADD ON THERAPY; ADULT; ARTICLE; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONVALESCENCE; DISEASE ASSOCIATION; EXPLANT; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GENETIC MARKER; HEART ASSIST DEVICE; HEART EJECTION FRACTION; HEART FAILURE; HUMAN; IMPLANTATION; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTIGENS, THY-1; COLLAGEN; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART; HEART FAILURE; HEART-ASSIST DEVICES; HUMANS; MATRIX METALLOPROTEINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; TREATMENT FAILURE; TREATMENT OUTCOME;

EID: 59349095082     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2008.11.910     Document Type: Article

References (29)

1. Dandel M., Weng Y., Siniawski H., et al. Long-term results in patients with idiopathic dilated cardiomyopathy after weaning from left ventricular assist devices. Circulation 112 (2005) I-37-45
2. Mancini D.M., Beniaminovitz A., Levin H., et al. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation 98 (1998) 2383-2389
3. Jaski B.E., Miller D.A., Hoagland P.M., et al. Assessment of recurrent heart failure associated with left ventricular assist device dysfunction. J Heart Lung Transplant 24 (2005) 2060-2067
4. Yacoub M.H. A novel strategy to maximize the efficacy of left ventricular assist devices as a bridge to recovery. Eur Heart J 22 (2001) 534-540
5. Birks E.J., Tansley P.D., Hardy J., et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med 355 (2006) 1873-1884
6. Spinale F.G. Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev 87 (2007) 1285-1342
7. Koide T. Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering. Phil Trans R Soc Lond B Biol Sci 362 (2007) 1281-1291
8. Bruckner B.A., Stetson S.J., Perez-Verdia A., et al. Regression of fibrosis and hypertrophy in failing myocardium following mechanical circulatory support. J Heart Lung Transplant 20 (2001) 457-464
9. Terracciano C.M., Hardy J., Birks E.J., et al. Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy. Circulation 109 (2004) 2263-2265
10. Xydas S., Rosen R.S., Ng C., et al. Mechanical unloading leads to echocardiographic, electrocardiographic, neurohormonal, and histologic recovery. J Heart Lung Transplant 25 (2006) 7-15
11. Bruggink A.H., de Jonge N., van Oosterhout M.F.M., et al. Brain natriuretic peptide is produced both by cardiomyocytes and cells infiltrating the heart in patients with severe heart failure supported by a left ventricular assist device. J Heart Lung Transplant 25 (2006) 174-180
12. Rodrigue-Way A., Burkhoff D., Geesaman B.J., et al. Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support. J Heart Lung Transplant 24 (2005) 73-80
13. Li Y.Y., Feng Y., McTiernan C., et al. Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing heart after support with left ventricular assist devices. Circulation 104 (2001) 1147-1152
14. Klotz S., Foronjy R.F., Dickstein M.L., et al. Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness. Circulation 112 (2005) 364-374
15. Nakatani S., McCarthy P.M., Kottke-Marchant K., et al. Left ventricular echocardiographic and histologic changes: impact of chronic unloading by an implantable ventricular assist device. J Am Coll Cardiol 27 (1996) 894-901
16. Klotz S., Danser A.H., Foronjy R.F., et al. The impact of angiotensin-converting enzyme inhibitor therapy on the extracellular collagen matrix during left ventricular assist device support in patients with end-stage heart failure. J Am Coll Cardiol 49 (2007) 1166-1174
17. Maybaum S., Mancini D., Xydas S., et al. Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group. Circulation 115 (2007) 2497-2505
18. Bruckner B.A., Razeghi P., Stetson S., et al. Degree of cardiac fibrosis and hypertrophy at time of implantation predicts myocardial improvement during left ventricular assist device support. J Heart Lung Transplant 23 (2004) 36-42
19. Thompson L.O., Skrabal C.A., Loebe M., et al. Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients. J Surg Res 123 (2005) 25-32
20. Felkin L.E., Taegtmeyer A.B., and Barton P.J. Real-time quantitative polymerase chain reaction in cardiac transplant research. Methods Mol Biol 333 (2006) 305-330
21. Felkin L.E., Birks E.J., George R., et al. A quantitative gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support. J Heart Lung Transplant 25 (2006) 1413-1419
22. Madigan J.D., Barbone A., Choudhri A.F., et al. Time course of reverse remodeling of the left ventricle during support with a left ventricular assist device. J Thorac Cardiovasc Surg 121 (2001) 902-908
23. Bruggink A.H., van Oosterhout M.F., de Jonge N., et al. Reverse remodeling of the myocardial extracellular matrix after prolonged left ventricular assist device support follows a biphasic pattern. J Heart Lung Transplant 25 (2006) 1091-1098
24. Milting H. Influence of ACE-inhibition and mechanical unloading on the regulation of extracellular matrix proteins in the myocardium of heart transplantation candidates bridged by ventricular assist devices. Eur J Heart Failure 8 (2006) 278-283
25. Rahkonen O.P., Koskivirta I.M.O., Oksjoki S.M., Jokinen E., and Vuorio E.I. Characterization of the murine Timp4 gene, localization within intron 5 of the synapsin 2 gene and tissue distribution of the mRNA. Biochim Biophys Acta (Gene Struct Express) 1577 (2002) 45-52
26. Barton P.J.R., Felkin L.E., Birks E.J., et al. Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy. Circulation 112 (2005) I-46-52
27. Pelosi L., Giacinti C., Nardis C., et al. Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines. FASEB J 21 (2007) 1393-1402
28. Santini M.P., Tsao L., Monassier L., et al. Enhancing repair of the mammalian heart. Circ Res 100 (2007) 1732-1740
29. Hall J.L., Grindle S., Han X., et al. Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiol Genomics 17 (2004) 283-291