The effects of lipophilic substances on the shape of erythrocytes demonstrated by a new in vitro-method

European Journal of Pharmaceutical Sciences

Volumn 36, Issue 4-5, 2009, Pages 458-464

  Söderberg, Lars ^a,b   Haag, Linnea ^a,b   Höglund, Peter ^a   Roth, Bodil ^a   Stenberg, Pål ^a   Wahlgren, Marie ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

EC50; Erythrocyte; Free fatty acids; In vitro method; Lipids; Trans fatty acid

Indexed keywords

ALCOHOL DERIVATIVE; ALIPHATIC AMINE; EDETIC ACID; FATTY ACID; LIPID; POLYCARBONATE; TRANS FATTY ACID;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONFORMATION; CONTROLLED STUDY; ERYTHROCYTE SHAPE; HILL REACTION; IN VITRO STUDY; LIPOPHILICITY; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; SOLUBILITY;

ALCOHOLS; AMINES; CELL SHAPE; ERYTHROCYTES; FATTY ACIDS; HUMANS;

EID: 59349090288     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.11.011     Document Type: Article

References (29)

1. Bayerle-Eder M., Polska E., Kopf A., Roden M., Waldhausl W., Pleiner H., Wipler B., Wolzt M., and Schmetterer L. Free fatty acids exert a greater effect on ocular and skin blood flow than triglycerides in healthy subjects. Eur. J. Clin. Invest. 34 (2004) 519-526
2. Bessis M. Red cell shapes. An illustrated classification and its rationale. Nouv. Rev. Fr. Hematol. 12 (1972) 721-745
3. Connor W.E., Hoak J.C., and Warner E.D. Massive thrombosis produced by fatty acid infusion. J. Clin. Invest. 42 (1963) 860-866
4. Dhainaut J.F., Huyghebaert M.F., Monsallier J.F., Lefevre G., Dall'Ava-Santucci J., Brunet F., Villemant D., Carli A., and Raichvarg D. Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 75 (1987) 533-541
5. Egan B.M., Lu G., and Greene E.L. Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster. Prostaglandins Leukotr. Essent. Fatty Acids 60 (1999) 411-420
6. Ferrell Jr. J.E., and Huestis W.H. Phosphoinositide metabolism and the morphology of human erythrocytes. J. Cell Biol. 98 (1984) 1992-1998
7. Hamilton J.A., Guo W., and Kamp F. Mechanism of cellular uptake of long-chain fatty acids: do we need cellular proteins?. Mol. Cell. Biochem. 239 (2002) 17-23
8. Hamilton J.A., and Kamp F. How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?. Diabetes 48 (1999) 2255-2269
9. Housley G.M., and Born G.V. Influence of charge and molecular size on membrane stabilization. Proc. Roy. Soc., Lond. B: Biol. Sci. 219 (1983) 83-90
10. Jann M.W., Ereshefsky L., and Saklad S.R. Clinical pharmacokinetics of the depot antipsychotics. Clin. Pharmacokinet. 10 (1985) 315-333
11. Kamada T., McMillan D.E., Sternlieb J.J., Bjork V.O., and Otsuji S. Erythrocyte crenation induced by free fatty acids in patients undergoing extracorporeal circulation. Lancet 2 (1987) 818-821
12. Kurien V.A., and Oliver M.F. Serum-free-fatty-acids after acute myocardial infarction and cerebral vascular occlusion. Lancet 2 (1966) 122-127
13. Lefevre G., Dhainaut J.F., Tallet F., Huyghebaert M.F., Yonger J., Monsallier J.F., and Raichvarg D. Individual free fatty acids and lactate uptake in the human heart during severe sepsis. Ann. Clin. Biochem. 25 Pt 5 (1988) 546-551
14. 2+-enriched human erythrocytes. An immunochemical study. J. Biol. Chem. 258 (1983) 5300-5305
15. 2+ stress. Blood 65 (1985) 1025-1027
16. Mozaffarian D., Katan M.B., Ascherio A., Stampfer M.J., and Willett W.C. Trans-fatty acids and cardiovascular disease. N. Engl. J. Med. 354 (2006) 1601-1613
17. Oliver M.F. Metabolic response during impending myocardial infarction. II. Clinical implications. Circulation 45 (1972) 491-500
18. Oro L., and Wretlind A. Pharmacological effects of fatty acids, triolein and cottonseed oil. Acta Pharmacol. Toxicol. (Copenh) 18 (1961) 141-152
19. Poraicu D., Sandor S., and Menessy I. Decrease of red blood cell filterability seen in intensive care. II. Red blood cell crenelation "in vivo" as morphological evidence of increased red blood cell viscosity in low flow states. Resuscitation 10 (1983) 305-316
20. Roden M., Price T.B., Perseghin G., Petersen K.F., Rothman D.L., Cline G.W., and Shulman G.I. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 97 (1996) 2859-2865
21. Shalel S., Streichman S., and Marmur A. The mechanism of hemolysis by surfactants: effect of solution composition. J. Colloid Interf. Sci. 252 (2002) 66-76
22. Soderberg L., Dyhre H., Roth B., and Bjorkman S. Ultralong peripheral nerve block by lidocaine:prilocaine 1:1 mixture in a lipid depot formulation: comparison of in vitro, in vivo, and effect kinetics. Anesthesiology 104 (2006) 110-121
23. Spector A.A. Fatty acid binding to plasma albumin. J. Lipid Res. 16 (1975) 165-179
24. Steigman J., Cohen I., and Spingola F. Micelle formation by a long-chain cation surfactant in aqueous solutions of the lower quaternary ammonium bromides. J. Colloid Sci. 20 (1965) 732-741
25. Steinberg H.O., Tarshoby M., Monestel R., Hook G., Cronin J., Johnson A., Bayazeed B., and Baron A.D. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J. Clin. Invest. 100 (1997) 1230-1239
26. Theilen H.J., Adam S., Albrecht M.D., and Ragaller M. Propofol in a medium- and long-chain triglyceride emulsion: pharmacological characteristics and potential beneficial effects. Anesth. Analg. 95 (2002) 923-929
27. van Schaick E.A., de Greef H.J., Langemeijer M.W., Sheehan M.J., Jzerman A.P.I., and Danhof M. Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats. Br. J. Pharmacol. 122 (1997) 525-533
28. von Dardel O., Mebius C., Mossberg T., and Svensson B. Fat emulsion as a vehicle for diazepam. A study of 9492 patients. Br. J. Anaesth. 55 (1983) 41-47
29. Zaets S.B., Berezina T.L., Xu D.Z., Lu Q., Ricci J., Cohen D., Ananthakrishnan P., Deitch E.A., and Machiedo G.W. Burn-induced red blood cell deformability and shape changes are modulated by sex hormones. Am. J. Surg. 186 (2003) 540-546