Neuroendocrine tumors: Novel approaches in the age of targeted therapy

ONCOLOGY

Volumn 22, Issue 14, 2008, Pages 1617-1623

  Phan, Alexandria T ^a   Yao, James C ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; ALPHA INTERFERON; ALPHA2B INTERFERON; ANGIOPEPTIN; BEVACIZUMAB; BORTEZOMIB; CYCLOPHOSPHAMIDE; DEPSIPEPTIDE; DOXORUBICIN; EVEROLIMUS; FLUOROURACIL; GEFITINIB; IMATINIB; INTERFERON; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MOTESANIB; OCTREOTIDE; PASIREOTIDE; PAZOPANIB; PLACEBO; SOMATOSTATIN DERIVATIVE; SORAFENIB; STREPTOZOCIN; SUNITINIB; TEMOZOLOMIDE; TEMSIROLIMUS; THALIDOMIDE; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR; VATALANIB;

ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG TARGETING; DRUG WITHDRAWAL; ENDOCRINE SURGERY; FATIGUE; GENE MUTATION; GENETIC DISORDER; HUMAN; LIVER METASTASIS; MOLECULAR GENETICS; MULTIPLE ENDOCRINE NEOPLASIA; NEUROENDOCRINE TUMOR; NEUROFIBROMATOSIS; PANCREAS TUMOR; REVIEW; RISK FACTOR; TUBEROUS SCLEROSIS; UNSPECIFIED SIDE EFFECT; VON HIPPEL LINDAU DISEASE;

ANTINEOPLASTIC AGENTS; CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; DRUG DESIGN; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NEUROENDOCRINE TUMORS; PROTEIN KINASES;

EID: 59349087915     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Yao JC, Hassan M, Phan A, et al: One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 26:3063-3072, 2008.
2. Yao JC: Molecular targeted therapy for carcinoid and islet-cell carcinoma. Best Pract Res Clin Endocrinol Metab 21:163-172, 2007.
3. Kouvaraki MA, Ajani JA, Hoff P, et al: Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol 22:4762-4771, 2004.
4. Lamberts SW, Krenning EP, Reubi JC: The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr Rev 12:450-482, 1991.
5. Schnirer II, Yao JC, Ajani JA: Carcinoid: A comprehensive review. Acta Oncol 42:672-692, 2003.
6. Kvols L, Wiedenmann B, Oberg K, et al: Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: Results of a phase II study (abstract 4082). J Clin Oncol 24(18S):198s, 2006.
7. Oberg K, Funa K, Alm G: Effects of leukocyte interferon on clinical symptoms and hormone levels in patients with mid-gut carcinoid tumors and carcinoid syndrome. N Engl J Med 309:129-133, 1983.
8. Detjen KM, Welzel M, Farwig K, et al: Molecular mechanism of interferon alfa-mediated growth inhibition in human neuroendocrine tumor cells. Gastroenterology 118:735-748, 2000.
9. Yao JC, Phan A, Hoff PM, et al: Targeting vascular endothelial growth factor in advanced carcinoid tumor: A random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J Clin Oncol 26:1316-1323, 2008.
10. Janson ET, Oberg K: Long-term management of the carcinoid syndrome. Treatment with octreotide alone and in combination with alpha-interferon. Acta Oncol 32:225-229, 1993.
11. Frank M, Klose KJ, Wied M, et al: Combination therapy with octreotide and alpha-interferon: effect on tumor growth in metastatic endocrine gastroenteropancreatic tumors. Am J Gastroenterol 94:1381-1387, 1999.
12. Faiss S, Pape UF, Bohmig M, et al: Prospective, randomized, multicenter trial on the antiproliferative effect of lanreotide, interferon alfa, and their combination for therapy of metastatic neuroendocrine gastroenteropancreatic tumors - the International Lanreotide and Interferon Alfa Study Group. J Clin Oncol 21:2689-2696, 2003.
13. Arnold R, Rinke A, Klose KJ, et al: Octreotide versus octreotide plus interferon-alpha in endocrine gastroenteropancreatic tumors: a randomized trial. Clin Gastroenterol Hepatol 3:761-771, 2005.
14. Yao JC, Rindi G, Evans DB: Pancreatic endocrine tumors, in De Vita VT, Lawrence TS, Rosenberg SA (eds): Cancer: Principles & Practice of Oncology, pp 1702-1721. Philadelphia, Wolters Kluwer/Lippincott Williams & Wilkins, 2008.
15. Kulke MH, Stuart K, Enzinger PC, et al: Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24:401-406, 2006.
16. Nagano Y, Kim DH, Zhang L, et al: Allelic alterations in pancreatic endocrine tumors identified by genome-wide single nucleotide polymorphism analysis. Endocr Relat Cancer 14:483-492, 2007.
17. Hughes CM, Rozenblatt-Rosen O, Milne TA, et al: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell 13:587-597, 2004.
18. Karnik SK, Hughes CM, Gu X, et al: Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A 102:14659-14664, 2005.
19. Verhoef S, van Diemen-Steenvoorde R, Akkersdijk WL, et al: Malignant pancreatic tumour within the spectrum of tuberous sclerosis complex in childhood. Eur J Pediatr 158:284-287, 1999.
20. Plank TL, Logginidou H, Klein-Szanto A, et al: The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas. Mod Pathol 12:539-545, 1999.
21. Johannessen CM, Reczek EE, James MF, et al: The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci U S A 102:8573-8578, 2005.
22. Iliopoulos O: von Hippel-Lindau disease: Genetic and clinical observations. Front Horm Res 28:131-166, 2001.
23. Hammel PR, Vilgrain V, Terris B, et al: Pancreatic involvement in von Hippel-Lindau disease. The Groupe Francophone d'Etude de la Maladie de von Hippel-Lindau. Gastroenterology 119:1087-1095, 2000.
24. Zhao J, Moch H, Scheidweiler AF, et al: Genomic imbalances in the progression of endocrine pancreatic tumors. Genes Chromosomes Cancer 32:364-372, 2001.
25. Kim do H, Nagano Y, Choi IS, et al: Allelic alterations in well-differentiated neuroendocrine tumors (carcinoid tumors) identified by genome-wide single nucleotide polymorphism analysis and comparison with pancreatic endocrine tumors. Genes Chromosomes Cancer 47:84-92, 2008.
26. Choi IS, Estecio MR, Nagano Y, et al: Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors). Mod Pathol 20:802-810, 2007.
27. Terris B, Scoazec JY, Rubbia L, et al: Expression of vascular endothelial growth factor in digestive neuroendocrine tumours. Histopathology 32: 133-138, 1998.
28. Ambs S, Bennett WP, Merriam WG, et al: Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. Br J Cancer 78:233-239, 1998.
29. Hobday TJ, Rubin J, Goldberg R, et al: Molecular markers in metastatic gastrointestinal neuroendocrine tumors (abstract 1078). Proc Am Soc Clin Oncol 22:269, 2003.
30. Cohen T, Herzog Y, Brodzky A, et al: Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours. J Pathol 198:77-82, 2002.
31. Paraskevakou H, Saetta A, Skandalis K, et al: Morphological-histochemical study of intestinal carcinoids and K-ras mutation analysis in appendiceal carcinoids. Pathol Oncol Res 5:205-210, 1999.
32. Kulke MH, Lenz HJ, Meropol NJ, et al: Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 26:3403-3410, 2008.
33. Hobday TJ, Rubin J, Holen K, et al: MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study. J Clin Oncol 25:4504, 2007.
34. Duran I, Kortmansky J, Singh D, et al: A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer 95:1148-1154, 2006.
35. Yao JC, Phan AT, Chang DZ, et al: Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: Results of a phase II study. J Clin Oncol 26:4311-4318, 2008.
36. Yao JC, Lombard-Bohas C, Baudin E, et al: A phase II trial of daily oral RAD001 (everolimus) in patients with metastatic pancreatic neuroendocrine tumors (NET) after failure of cytotoxic chemotherapy (abstract 508PD). Ann Oncol 19:viii167, 2008.
37. Yao JC, Zhang JX, Rashid A, et al: Clinical and in vitro studies of imatinib in advanced carcinoid tumors. Clin Cancer Res 13:234-240, 2007.
38. Gross DJ, Munter G, Bitan M, et al: The role of imatinib mesylate (Glivec) for treatment of patients with malignant endocrine tumors positive for c-kit or PDGF-R. Endocr Relat Cancer 13:535-540, 2006.
39. Papouchado B, Erickson LA, Rohlinger AL, et al: Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. Mod Pathol 18:1329-1335, 2005.
40. Hobday T, Holen K, Donehower R, et al: A phase II trial of gefitinib in patients (pts) with progressive metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study (abstract 4043). J Clin Oncol 24(18S):189s, 2006.
41. Shah MH, Young D, Kindler HL, et al: Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors. Clin Cancer Res 10:6111-6118, 2004.
42. Shah MH, Binkley P, Chan K, et al: Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors. Clin Cancer Res 112:3997-4003, 2006.
43. Anthony L, Chester M, Michael S, et al: Phase II open-label clinical trial of vatalanib (PTK/ZK) in patients with progressive neuroendocrine cancer (abstract 14624). J Clin Oncol 26(15S):637s, 2008.