Remediation of undesirable secondary interactions encountered in hydrophilic interaction chromatography during development of a quantitative LC-MS/MS assay for a dipeptidyl peptidase IV (DPP-IV) inhibitor in monkey serum

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 5-6, 2009, Pages 471-476

  Kadar, Eugene P ^a   Wujcik, Chad E ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

Bioanalysis; Dipeptidyl peptidase IV (DPP IV) inhibitor; HILIC; Hydrophilic interaction chromatography; LC MS MS

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ETHYLENE; ETHYLENE GLYCOL; EXTRACTION; GLYCOLS; HYDROPHILICITY; MILITARY ENGINEERING; SUGAR (SUCROSE);

BIOANALYSIS; DIPEPTIDYL PEPTIDASE IV (DPP-IV) INHIBITOR; HILIC; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LC-MS/MS;

LIQUID CHROMATOGRAPHY;

3,3 DIFLUOROPYRROLIDIN 1 YL [4 (4 PYRIMIDIN 2 YL)PIPERAZIN 1 YL)PYRROLIDIN 2 YL]METHANONE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ETHYLENE GLYCOL; PF 00734200; SILANOL; UNCLASSIFIED DRUG;

ARTICLE; CORRELATION COEFFICIENT; ELECTRICITY; ENZYME ASSAY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR INTERACTION; MONKEY SERUM; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REDUCTION; SERUM; VALIDATION PROCESS;

ACETONITRILES; ANIMALS; ANTIGENS, CD26; BUFFERS; CHROMATOGRAPHY, LIQUID; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HAPLORHINI; INJECTIONS; MASS SPECTROMETRY; PARTICLE SIZE; REPRODUCIBILITY OF RESULTS;

EID: 59249105097     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.11.048     Document Type: Article

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