Midkine accumulated in nucleolus of HepG2 cells involved in rRNA transcription

World Journal of Gastroenterology

Volumn 14, Issue 40, 2008, Pages 6249-6253

  Dai, Li Cheng ^a   Shao, Jian Zhong ^b   Min, Li Shan ^a   Xiao, Yong Tao ^b   Xiang, Li Xin ^b   Ma, Zhi Hong ^a  

^a HUZHOU CENTRAL HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

45S rRNA; Anti apotosis; Midkine; Proliferation

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MIDKINE; PROPIDIUM IODIDE; RIBOSOME RNA; ANTISENSE OLIGONUCLEOTIDE; MDK PROTEIN, HUMAN; NERVE GROWTH FACTOR; RNA, RIBOSOMAL, 45S;

APOPTOSIS; ARTICLE; BIOGENESIS; CANCER CELL CULTURE; CELL ACTIVITY; CELL GRANULE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; NUCLEOLUS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; STAINING; ACTIVE TRANSPORT; CELL SEPARATION; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GENETICS; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; POLYMERASE CHAIN REACTION; TUMOR CELL LINE; ULTRASTRUCTURE;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL NUCLEOLUS; CELL PROLIFERATION; CELL SEPARATION; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; MICROSCOPY, IMMUNOELECTRON; NERVE GROWTH FACTORS; OLIGONUCLEOTIDES, ANTISENSE; POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL; TRANSCRIPTION, GENETIC;

EID: 59249102048     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.6249     Document Type: Article

References (16)

1. Muramatsu T. [Midkine (MK): a retinoic acid-responsive, heparin-binding growth factor in relationship with differentiation, development, cancer and neural function] Seikagaku 1993; 65: 1494-1504
2. Michikawa M, Kikuchi S, Muramatsu H, Muramatsu T, Kim SU. Retinoic acid responsive gene product, midkine, has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J Neurosci Res 1993; 35: 530-539
3. Michikawa M, Xu RY, Muramatsu H, Muramatsu T, Kim SU. Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells. Biochem Biophys Res Commun 1993; 192: 1312-1318
4. Garver RI Jr, Radford DM, Donis-Keller H, Wick MR, Milner PG. Midkine and pleiotrophin expression in normal and malignant breast tissue. Cancer 1994; 74: 1584-1590
5. Take M, Tsutsui J, Obama H, Ozawa M, Nakayama T, Maruyama I, Arima T, Muramatsu T. Identification of nucleolin as a binding protein for midkine (MK) and heparin-binding growth associated molecule (HB-GAM). J Biochem 1994; 116: 1063-1068
6. Kojima S, Muramatsu H, Amanuma H, Muramatsu T. Midkine enhances fibrinolytic activity of bovine endothelial cells. J Biol Chem 1995; 270: 9590-9596
7. Adachi Y, Matsubara S, Pedraza C, Ozawa M, Tsutsui J, Takamatsu H, Noguchi H, Akiyama T, Muramatsu T. Midkine as a novel target gene for the Wilms' tumor suppressor gene (WT1). Oncogene 1996; 13: 2197-2203
8. Kadomatsu K, Muramatsu T. Midkine and pleiotrophin in neural development and cancer. Cancer Lett 2004; 204: 127-143
9. Kawai H, Sato W, Yuzawa Y, Kosugi T, Matsuo S, Takei Y, Kadomatsu K, Muramatsu T. Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage. Am J Pathol 2004; 165: 1603-1612
10. Friedrich C, Holtkamp N, Cinatl J Jr, Sakuma S, Mautner VF, Wellman S, Michaelis M, Henze G, Kurtz A, Driever PH. Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency. Int J Oncol 2005; 27: 1433-1440
11. Shibata Y, Muramatsu T, Hirai M, Inui T, Kimura T, Saito H, McCormick LM, Bu G, Kadomatsu K. Nuclear targeting by the growth factor midkine. Mol Cell Biol 2002; 22: 6788-6796
12. Dai L, Xu D, Yao X, Lu Y, Xu Z. Conformational determinants of the intracellular localization of midkine. Biochem Biophys Res Commun 2005; 330: 310-317
13. Dai LC, Xu DY, Yao X, Min LS, Zhao N, Xu BY, Xu ZP, Lu YL. Construction of a fusion protein expression vector MK-EGFP and its subcellular localization in different carcinoma cell lines. World J Gastroenterol 2006; 12: 7649-7653
14. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70
15. Cmarko D, Verschure PJ, Rothblum LI, Hernandez-Verdun D, Amalric F, van Driel R, Fakan S. Ultrastructural analysis of nucleolar transcription in cells microinjected with 5-bromo-UTP. Histochem Cell Biol 2000; 113: 181-187
16. Ruggero D, Pandolfi PP. Does the ribosome translate cancer? Nat Rev Cancer 2003; 3: 179-192