Fermented Noni Exudate (fNE): A mediator between immune system and anti-tumor activity

Oncology Reports

Volumn 20, Issue 6, 2008, Pages 1505-1509

  Li, Jinhua ^a   Stickel, Sara L ^a   Bouton Verville, Hilary ^a   Burgin, Kelly E ^a   Yu, Xianzhong ^a,b   Wong, Desmond K W ^c   Wagner, Thomas E ^a,b   Wei, Yanzhang ^a,b  

^a Children's Hospital   (United States)

^b CLEMSON UNIVERSITY   (United States)

^c UNIVERSITY OF HAWAII   (United States)

Author keywords

Fermented noni exudate; Innate immunity; NK cells; S180

Indexed keywords

MORINDA CITRIFOLIA EXTRACT; ANTINEOPLASTIC AGENT; PLANT EXTRACT;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; FERMENTED PRODUCT; FRUIT JUICE; GRANULOCYTE; IMMUNE SYSTEM; IMMUNOSTIMULATION; INNATE IMMUNITY; LEUKOCYTE COUNT; LEWIS CARCINOMA; LYMPHOCYTE FUNCTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SARCOMA 180; SOLID TUMOR; ANIMAL; ASCITES; C57BL MOUSE; EXUDATE; FERMENTATION; FRUIT; METABOLISM; MORINDA; MOUSE MUTANT; NUDE MOUSE; SARCOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; ASCITES; EXUDATES AND TRANSUDATES; FEMALE; FERMENTATION; FRUIT; IMMUNE SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; MORINDA; PLANT EXTRACTS; SARCOMA;

EID: 59249096121     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000172     Document Type: Article

References (10)

1. McClatchey W: From Polynesian healers to health food stores: changing perspectives of Morinda citrifolia (Rubiaceae). Integr Cancer Ther 1: 110-120, 2002.
2. Hirazumi A, Furusawa E, Chou SC and Kokama Y: Immunomodulation contributes to the anticancer activity of morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc 39: 7-9, 1996.
3. Hirazumi A, Furusawa E, Chou SC and Hokama Y: Anticancer activity of Morinda citrifolia (noni) on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice. Proc West Pharmacol Soc 37: 145-146, 1994.
4. Hornick CA, Myers A, Sadowska-Krowicka H, Anthony CT and Woltering EA: Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni). Angiogenesis 6: 143-149, 2003.
5. Kim IT, Park HJ, Nam JH, Park YM, Won JH, Choi J, Choe BK and Lee KT: In-vitro and in-vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis. J Pharm Pharmacol 57: 607-615, 2005.
6. Liu G, Bode A, Ma WY, Sang S, Ho CT and Dong Z: Two novel glycosides from the fruit of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res 61: 5749-5756, 2001.
7. Hirazumi A and Furusawa E: An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumor activity. Phytother Res 13: 380-387, 1999.
8. Wang MY and Su C: Cancer preventive effect of Morinda citrifolia (noni). Ann NY Acad Sci 952: 161-168, 2001.
9. Furusawa E, Hirazumi A, Story S and Jensen J: Antitumor potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumor in mice. Phytother Res 17: 1158-1164, 2003.
10. Wong DK: Are immune responses pivotal to cancer patient's long term survival? Two clinical case-study reports on the effects of Morinda citrifolia (Noni). Hawaii Med J 63:1 82-184, 2004.