Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma

Oncology Reports

Volumn 20, Issue 6, 2008, Pages 1375-1380

  Inami, Koichi ^a   Kajino, Kazunori ^a   Abe, Masaaki ^a   Hagiwara, Yoshiaki ^a,b   Maeda, Masahiro ^b   Suyama, Masafumi ^a   Watanabe, Sumio ^a   Hino, Okio ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Immuno Biological Laboratories Co Ltd   (Japan)

Author keywords

ELISA; ERC mesothelin; Immunohistochemistry; Pancreatic ductal carcinoma

Indexed keywords

MESOTHELIN; MEGAKARYOCYTE POTENTIATING FACTOR; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; TUMOR ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BIOSYNTHESIS; BLOOD; CHEMISTRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; IMMUNOTHERAPY; METABOLISM; METHODOLOGY; MIDDLE AGED; PANCREAS TUMOR; SECRETION; TUMOR CELL LINE;

AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOTHERAPY; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PANCREATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 59249092574     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000155     Document Type: Article

References (26)

1. Chang K and Pastan I: Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc Natl Acad Sci USA 93: 136-140, 1996.
2. Hassan R, Bera T and Pastan I: Mesothelin: a new target for immunotherapy. Clin Cancer Res 10: 3937-3942, 2004.
3. Yamaguchi N, Hattori K, Oh-eda M, Kojima T, Imai N and Ochi N: A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5. J Biol Chem 269: 805-808, 1994.
4. Kojima T, Oh-eda M, Hattori K, et al: Molecular cloning and expression of megakaryocyte potentiating factor cDNA. J Biol Chem 270: 21984-21990, 1995.
5. Shiomi K, Miyamoto H, Segawa T, et al: Novel ELISA system for detection of N-ERC/mesothelin in the sera of mesothelioma patients. Cancer Sci 97: 928-932, 2006.
6. Shiomi K, Hagiwara Y, Sonoue K, et al: Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/Mesothelin increases its potential as a useful serum tumor marker for mesothelioma. Clin Cancer Res 14: 1431-1437, 2008.
7. Hino O and Shiomi K: Diagnostic biomarker of asbestos-related mesothelioma: Example of translational research. Cancer Sci 98: 1147-1157, 2007.
8. Scholler N, Fu N, Yang Y, et al: Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. Proc Natl Acad Sci USA 96: 11531-11536, 1999.
9. Onda M, Nagata S, Ho M, et al: Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma. Clin Cancer Res 12: 4225-4231, 2006.
10. Hassan R, Remaley AT, Sampson ML, et al: Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clin Cancer Res 12: 447-453, 2006.
11. Robinson BW, Creaney J, Lake R, et al: Mesothelin-family proteins and diagnosis of mesothelioma. Lancet 15: 1612-1616, 2003.
12. Robinson BW, Creaney J, Lake R, Nowak A, Musk AW, de Klerk N, Winzell P, Hellstrom KE and Hellstrom I: Soluble mesothelin-related protein - a blood test for mesothelioma. Lung Cancer 49: S109-S111, 2005.
13. Sapede C, Gauvrit A, Barbieux I, et al: Aberrant splicing and protease involvement in mesothelin release from epithelioid mesothelioma cells. Cancer Sci 99: 590-594, 2008.
14. Chang K, Pastan I and Willingham M: Frequent expression of the tumor antigen CAK1 in squamous-cell carcinomas. Int J Cancer 51: 548-554, 1992.
15. Argani P, Iacobuzio-Donahue C, Ryu B, et al: Mesothelin is overexpressed in the vast majority of ductal adenocarinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res 7: 3862-3868, 2001.
16. Baruch AC, Wang H, Staerkel GA, Evans DB, Hwang RF and Krishnamurthy S: Immunocytochemical study of the expression of mesothelin in fine-needle aspiration biopsy specimens of pancreatic adenocarcinoma. Diagn Cytopathol 35: 143-147, 2007.
17. Yaziji H, Battifora H, Barry TS, et al: Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity. Mod Pathol 19: 514-523, 2006.
18. Segawa T, Hagiwara Y, Ishikawa K, et al: MESOMARK kit detects C-ERC/mesothelin, but not SMRP with C-terminus. Biochem Biophys Res Commun 369: 915-918, 2008.
19. Yamashita Y, Yokoyama M, Kobayashi E, Takai S and Hino O: Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model. Biochem Biophys Res Commun 275: 134-140, 2000.
20. Maeda M and O Hino: Molecular tumor marker for asbestos-related mesothelioma: serum diagnostic markers. Pathol Int 56: 649-654, 2006.
21. Maeda M and O Hino: Blood test for asbestos-related mesothelioma. Oncology 71: 26-31, 2006.
22. Wray CJ, Ahmad SA, Matthews JB and Lowy AM: Surgery for pancreatic cancer: recent controversies and current practice. Gastroenterology 128: 1626-1641, 2005.
23. Li D, Xie K, Wolff R and Abbruzzese JL: Pancreatic cancer. Lancet 363: 1049-1057, 2004.
24. Matsuno S, Egawa S, Fukuyama S, et al: Pancreatic cancer registry in Japan: 20 years of experience. Pancreas 28: 219-230, 2004.
25. Egawa S, Takeda K, Fukuyama S, Motoi F, Sunamura M and Matsuno S: Clinicopathological aspects of small cancer. Pancreas 28: 235-240, 2004.
26. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.