Gastrointestinal tract modelling in health and disease

World Journal of Gastroenterology

Volumn 15, Issue 2, 2009, Pages 169-176

  Liao, Dong Hua ^a   Zhao, Jing Bo ^a   Gregersen, Hans ^a,b,c  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Biomechanics; Computational modelling; Disease; Gastrointestinal tract; Remodelling

Indexed keywords

ABDOMINAL PAIN; ANATOMY; BIOCHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; CORRELATIONAL STUDY; COST CONTROL; DIGESTION; DISEASE MODEL; DYSPEPSIA; EARLY DIAGNOSIS; FUNCTIONAL ASSESSMENT; GASTROENTEROLOGY; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MOTILITY DISORDER; GASTROINTESTINAL TRACT FUNCTION; GASTROPLASTY; GEOMETRY; HEALTH CARE COST; HISTOPATHOLOGY; HUMAN; INTERSTITIAL CELL OF CAJAL; INTESTINE INNERVATION; INTESTINE MOTILITY; MEDICAL RESEARCH; MOTOR DYSFUNCTION; MOTOR NERVE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PATHOPHYSIOLOGY; REVIEW; SENSORY DYSFUNCTION; SMOOTH MUSCLE CONTRACTION; STOMACH BYPASS; STOMACH EMPTYING; STOMACH MOTILITY; THREE DIMENSIONAL IMAGING;

EID: 59249089456     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.169     Document Type: Review

References (81)

1. Berstad A, Hausken T, Gilja OH, Hveem K, Nesje LB, Odegaard S. Ultrasonography of the human stomach. Scand J Gastroenterol Suppl 1996; 220: 75-82
2. Berstad A, Hausken T, Gilja OH, Nesland A, Odegaard S. Imaging studies in dyspepsia. Eur J Surg Suppl 1998; 42-49
3. Frokjaer JB, Liao D, Bergmann A, McMahon BP, Steffensen E, Drewes AM, Gregersen H. Three-dimensional biomechanical properties of the human rectum evaluated with magnetic resonance imaging. Neurogastroenterol Motil 2005; 17: 531-540
4. Frokjaer JB, Liao D, Steffensen E, Dimcevski G, Bergmann A, Drewes AM, Gregersen H. Geometric and mechanosensory properties of the sigmoid colon evaluated with magnetic resonance imaging. Neurogastroenterol Motil 2007; 19: 253-262
5. Gilja OH, Lunding J, Hausken T, Gregersen H. Gastric accommodation assessed by ultrasonography. World J Gastroenterol 2006; 12: 2825-2829
6. Gilja OH, Hatlebakk JG, Odegaard S, Berstad A, Viola I, Giertsen C, Hausken T, Gregersen H. Advanced imaging and visualization in gastrointestinal disorders. World J Gastroenterol 2007; 13: 1408-1421
7. Clapworthy GJ, Viceconti M. Seeing the EuroPhysiome: A roadmap to the Virtual Physiological Human. (Coordination Action #027642, STEP: A strategy for the EuroPhysiome). Luton: University of Bedfordshire, 2007
8. Hunter PJ, Nielsen PM, Bullivant D. The IUPS Physiome Project. International Union of Physiological Sciences. Novartis Found Symp 2002; 247: 207-217; discussion 217-221, 244-252
9. Hunter P, Nielsen P. A strategy for integrative computational physiology. Physiology (Bethesda) 2005; 20: 316-325
10. Liao D, Lelic D, Gao F, Drewes AM, Gregersen H. Biomechanical functional and sensory modelling of the gastrointestinal tract. Philos Transact A Math Phys Eng Sci 2008; 366: 3281-3299
11. Gregersen H. The Giome project. Neurogastroenterol Motil 2006; 18: 401-402
12. Gregersen H, Kassab G. Biomechanics of the gastrointestinal tract. Neurogastroenterol Motil 1996; 8: 277-297
13. Takaki M. Gut pacemaker cells: the interstitial cells of Cajal (ICC). J Smooth Muscle Res 2003; 39: 137-161
14. Burns AJ. Disorders of interstitial cells of Cajal. J Pediatr Gastroenterol Nutr 2007; 45 Suppl 2: S103-S106
15. Sanders KM, Ordog T, Ward SM. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol 2002; 282: G747-G756
16. Guyton AC, Hall JE. Medical Physiology. 10th ed. Philadelphia: WB Saunders Company, 2000
17. Drewes AM, Gregersen H, Arendt-Nielsen L. Experimental pain in gastroenterology: a reappraisal of human studies. Scand J Gastroenterol 2003; 38: 1115-1130
18. Camilleri M. New imaging in neurogastroenterology: an overview. Neurogastroenterol Motil 2006; 18: 805-812
19. Frokjaer JB, Andersen SD, Ejskjaer N, Funch-Jensen P, Drewes AM, Gregersen H. Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1. World J Gastroenterol 2007; 13: 4881-4890
20. Pedersen J, Gao C, Egekvist H, Bjerring P, Arendt-Nielsen L, Gregersen H, Drewes AM. Pain and biomechanical responses to distention of the duodenum in patients with systemic sclerosis. Gastroenterology 2003; 124: 1230-1239
21. Gregersen H, Lu X, Zhao J. Physiological growth is associated with esophageal morphometric and biomechanical changes in rats. Neurogastroenterol Motil 2004; 16: 403-412
22. Lu X, Zhao J, Gregersen H. Small intestinal morphometric and biomechanical changes during physiological growth in rats. J Biomech 2005; 38: 417-426
23. Dou Y, Gregersen S, Zhao J, Zhuang F, Gregersen H. Effect of re-feeding after starvation on biomechanical properties in rat small intestine. Med Eng Phys 2001; 23: 557-566
24. Dou Y, Gregersen S, Zhao J, Zhuang F, Gregersen H. Morphometric and biomechanical intestinal remodeling induced by fasting in rats. Dig Dis Sci 2002; 47: 1158-1168
25. Gregersen H, Giversen IM, Rasmussen LM, Tottrup A. Biomechanical wall properties and collagen content in the partially obstructed opossum esophagus. Gastroenterology 1992; 103: 1547-1551
26. Storkholm JH, Zhao J, Villadsen GE, Hager H, Jensen SL, Gregersen H. Biomechanical remodeling of the chronically obstructed Guinea pig small intestine. Dig Dis Sci 2007; 52: 336-346
27. Storkholm JH, Zhao J, Villadsen GE, Gregersen H. Spontaneous and bolus-induced motility in the chronically obstructed guinea-pig small intestine in vitro. Dig Dis Sci 2008; 53: 413-420
28. Dou Y, Lu X, Zhao J, Gregersen H. Morphometric and biomechanical remodelling in the intestine after small bowel resection in the rat. Neurogastroenterol Motil 2002; 14: 43-53
29. Jorgensen CS, Ahrensberg JM, Gregersen H, Flyvberg A. Tension-strain relations and morphometry of rat small intestine in experimental diabetes. Dig Dis Sci 2001; 46: 960-967
30. Liao D, Zhao J, Gregersen H. Three-dimensional geometry analysis of the stomach in type II diabetic GK rats. Diabetes Res Clin Pract 2006; 71: 1-13
31. Yang J, Zhao J, Zeng Y, Gregersen H. Biomechanical properties of the rat oesophagus in experimental type-1 diabetes. Neurogastroenterol Motil 2004; 16: 195-203
32. Yang J, Zhao J, Liao D, Gregersen H. Biomechanical properties of the layered oesophagus and its remodelling in experimental type-1 diabetes. J Biomech 2006; 39: 894-904
33. Zhao J, Frokjaer JB, Drewes AM, Ejskjaer N. Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus. World J Gastroenterol 2006; 12: 2846-2857
34. Gregersen H, Lundby L, Overgaard J. Early and late effects of irradiation on morphometry and residual strain of mouse rectum. Dig Dis Sci 2002; 47: 1472-1479
35. Gregersen H, Weis SM, McCulloch AD. Oesophageal morphometry and residual strain in a mouse model of osteogenesis imperfecta. Neurogastroenterol Motil 2001; 13: 457-464
36. Fan Y, Zhao J, Liao D, Gregersen H. The effect of digestion of collagen and elastin on histomorphometry and the zero-stress state in rat esophagus. Dig Dis Sci 2005; 50: 1497-1505
37. Zhao J, Sha H, Zhou S, Tong X, Zhuang FY, Gregersen H. Remodelling of zero-stress state of small intestine in streptozotocin-induced diabetic rats. Effect of gliclazide. Dig Liver Dis 2002; 34: 707-716
38. Zhao J, Liao D, Yang J, Gregersen H. Viscoelastic behavior of small intestine in streptozotocin-induced diabetic rats. Dig Dis Sci 2003; 48: 2271-2277
39. Zhao J, Yang J, Gregersen H. Biomechanical and morphometric intestinal remodelling during experimental diabetes in rats. Diabetologia 2003; 46: 1688-1697
40. Zhao J, Liao D, Gregersen H. Biomechanical and histomorphometric esophageal remodeling in type 2 diabetic GK rats. J Diabetes Complications 2007; 21: 34-40
41. Liao D, Yang J, Zhao J, Zeng Y, Vinter-Jensen L, Gregersen H. The effect of epidermal growth factor on the incremental Young's moduli in the rat small intestine. Med Eng Phys 2003; 25: 413-418
42. Yang J, Zhao JB, Zeng YJ, Gregersen H. Biomechanical properties of ileum after systemic treatment with epithelial growth factor. World J Gastroenterol 2003; 9: 2278-2283
43. Yang J, Zhao J, Zeng Y, Vinter-Jensen L, Gregersen H. Morphological properties of zero-stress state in rat large intestine during systemic EGF treatment. Dig Dis Sci 2003; 48: 442-448
44. Zhao J, Yang J, Vinter-Jensen L, Zhuang F, Gregersen H. Biomechanical properties of esophagus during systemic treatment with epidermal growth factor in rats. Ann Biomed Eng 2003; 31: 700-709
45. Zhao J, Yang J, Vinter-Jensen L, Zhuang F, Gregersen H. The morphometry and biomechanical properties of the rat small intestine after systemic treatment with epidermal growth factor. Biorheology 2002; 39: 719-733
46. Fung YC. Biomechanics mechanical properties of living tissues. Berlin: Springer-Verlag, 1993
47. Natali AN, Carniel EL, Pavan PG, Dario P, Izzo I, Menciassi A. Evaluation of the constitutive parameters for the numerical analysis of non linear mechanical response of soft tissues. VII Symposium of Computer Method in Biomechanics and Biomedical Engineering, Antibes, 2006
48. Natali AN, Carniel EL, Pavan PG, Dario P, Izzo I, Menciassi A. Hyperelastic models for the analysis of soft tissue mechanics: definition of constitutive parameters. 2006 IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, Pisa, 1-8, 2006
49. Liao D, Zhao J, Yang J, Gregersen H. The oesophageal zero-stress state and mucosal folding from a GIOME perspective. World J Gastroenterol 2007; 13: 1347-1351
50. Liao D, Cassin J, Zhao J, Gregersen H. The geometric configuration and morphometry of the rabbit oesophagus during luminal pressure loading. Physiol Meas 2006; 27: 703-711
51. Yang W, Fung TC, Chian KS, Chong CK. Three-dimensional finite element model of the two-layered oesophagus, including the effects of residual strains and buckling of mucosa. Proc Inst Mech Eng [H] 2007; 221: 417-426
52. Liao D, Fan Y, Zeng Y, Gregersen H. Stress distribution in the layered wall of the rat oesophagus. Med Eng Phys 2003; 25: 731-738
53. Liao D, Zhao J, Fan Y, Gregersen H. Two-layered quasi-3D finite element model of the oesophagus. Med Eng Phys 2004; 26: 535-543
54. Yang W, Fung TC, Chian KS, Chong CK. Instability of the two-layered thick-walled esophageal model under the external pressure and circular outer boundary condition. J Biomech 2007; 40: 481-490
55. Gasser TC, Ogden RW, Holzapfel GA. Hyperelastic modelling of arterial layers with distributed collagen fibre orientations. J R Soc Interface 2006; 3: 15-35
56. Holzapfel GA, Gasser TC, Ogden RW. Comparison of a multi-layer structural model for arterial walls with a fung-type model, and issues of material stability. J Biomech Eng 2004; 126: 264-275
57. Yang W, Fung TC, Chian KS, Chong CK. Directional, regional, and layer variations of mechanical properties of esophageal tissue and its interpretation using a structure-based constitutive model. J Biomech Eng 2006; 128: 409-418
58. Drewes AM, Arendt-Nielsen L, Funch-Jensen P, Gregersen H. Experimental human pain models in gastro-esophageal reflux disease and unexplained chest pain. World J Gastroenterol 2006; 12: 2806-2817
59. Drewes AM, Gregersen H. Multimodal pain stimulation of the gastrointestinal tract. World J Gastroenterol 2006; 12: 2477-2486
60. Gregersen H, Drewes AM, McMahon BP, Liao D. Balloon-distension studies in the gastrointestinal tract: current role. Dig Dis 2006; 24: 286-296
61. Gregersen H, Liao D, Pedersen J, Drewes AM. A new method for evaluation of intestinal muscle contraction properties: studies in normal subjects and in patients with systemic sclerosis. Neurogastroenterol Motil 2007; 19: 11-19
62. Pedersen J, Drewes AM, Gregersen H. New analysis for the study of the muscle function in the human oesophagus. Neurogastroenterol Motil 2005; 17: 767-772
63. Frokjaer JB, Andersen SD, Drewes AM, Gregersen H. Ultrasound-determined geometric and biomechanical properties of the human duodenum. Dig Dis Sci 2006; 51: 1662-1669
64. Li M, Brasseur JG, Dodds WJ. Analyses of normal and abnormal esophageal transport using computer simulations. Am J Physiol 1994; 266: G525-G543
65. Jeays AD, Lawford PV, Gillott R, Spencer P, Barber DC, Bardhan KD, Hose DR. Characterisation of the haemodynamics of the superior mesenteric artery. J Biomech 2007; 40: 1916-1926
66. Liao D, Gregersen H, Hausken T, Gilja OH, Mundt M, Kassab G. Analysis of surface geometry of the human stomach using real-time 3-D ultrasonography in vivo. Neurogastroenterol Motil 2004; 16: 315-324
67. McMahon BP, Frokjaer JB, Kunwald P, Liao D, Funch-Jensen P, Drewes AM, Gregersen H. The functional lumen imaging probe (FLIP) for evaluation of the esophagogastric junction. Am J Physiol Gastrointest Liver Physiol 2007; 292: G377-G384
68. Nicosia MA, Brasseur JG, Liu JB, Miller LS. Local longitudinal muscle shortening of the human esophagus from high-frequency ultrasonography. Am J Physiol Gastrointest Liver Physiol 2001; 281: G1022-G1033
69. Buist ML, Cheng LK, Sanders KM, Pullan AJ. Multiscale modelling of human gastric electric activity: can the electrogastrogram detect functional electrical uncoupling? Exp Physiol 2006; 91: 383-390
70. Buist ML, Cheng LK, Yassi R, Bradshaw LA, Richards WO, Pullan AJ. An anatomical model of the gastric system for producing bioelectric and biomagnetic fields. Physiol Meas 2004; 25: 849-861
71. Cheng LK, Komuro R, Austin TM, Buist ML, Pullan AJ. Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity. World J Gastroenterol 2007; 13: 1378-1383
72. Lin AS, Buist ML, Cheng LK, Smith NP, Pullan AJ. Computational simulations of the human magneto- and electroenterogram. Ann Biomed Eng 2006; 34: 1322-1331
73. Lin AS, Buist ML, Smith NP, Pullan AJ. Modelling slow wave activity in the small intestine. J Theor Biol 2006; 242: 356-362
74. Pullan A, Cheng L, Yassi R, Buist M. Modelling gastrointestinal bioelectric activity. Prog Biophys Mol Biol 2004; 85: 523-550
75. Yassi R, Cheng LK, Al-Ali S, Smith NP, Pullan AJ, Windsor JA. An anatomically based mathematical model of the gastroesophageal junction. Conf Proc IEEE Eng Med Biol Soc 2004; 1: 635-638
76. Brasseur JG, Nicosia MA, Pal A, Miller LS. Function of longitudinal vs circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling. World J Gastroenterol 2007; 13: 1335-1346
77. Gao F, Liao D, Zhao J, Drewes AM, Gregersen H. Numerical analysis of pouch filling and emptying after laparoscopic gastric banding surgery. Obes Surg 2008; 18: 243-250
78. Dillard S, Krishnan S, Udaykumar HS. Mechanics of flow and mixing at antroduodenal junction. World J Gastroenterol 2007; 13: 1365-1371
79. McMahon BP, Odie KD, Moloney KW, Gregersen H. Computation of flow through the oesophagogastric junction. World J Gastroenterol 2007; 13: 1360-1364
80. Pal A, Brasseur JG, Abrahamsson B. A stomach road or "Magenstrasse" for gastric emptying. J Biomech 2007; 40: 1202-1210
81. Yang W, Fung TC, Chian KS, Chong CK. Finite element simulation of food transport through the esophageal body. World J Gastroenterol 2007; 13: 1352-1359